公开(公告)号：DE69822870T2

公开(公告)日：2005-03-17

申请号：DE69822870

申请日：1998-11-17

Applicant: ABBOTT LAB

Inventor： HENGEVELD E ,  DONG XIAOXING ,  GUPTA K ,  COPP R ,  PREMCHANDRAN H

IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

Abstract: Disclosed is an improved and efficient process for N-desmethylating the 3'-amino nitrogen of erythromycins and for converting the 3'-N-desmethylated erythromycins into 3'-N-substituted derivatives of 8,9-anhydro-erythromycin 6,9-hemiketals.

公开(公告)号：DE69822870D1

公开(公告)日：2004-05-06

申请号：DE69822870

申请日：1998-11-17

Applicant: ABBOTT LAB

Inventor： HENGEVELD E ,  DONG XIAOXING ,  GUPTA K ,  COPP R ,  PREMCHANDRAN H

IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

Abstract: Disclosed is an improved and efficient process for N-desmethylating the 3'-amino nitrogen of erythromycins and for converting the 3'-N-desmethylated erythromycins into 3'-N-substituted derivatives of 8,9-anhydro-erythromycin 6,9-hemiketals.