公开(公告)号：ES2221224T3

公开(公告)日：2004-12-16

申请号：ES98958010

申请日：1998-11-17

Applicant: ABBOTT LAB

Inventor： HENGEVELD JOHN E ,  DONG XIAOXING ,  GUPTA ASHOK K ,  COPP RICHARD R JR ,  PREMCHANDRAN RAMIYA H

IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

Abstract: Un proceso para preparar un compuesto representado por la fórmula: **(Fórmula)** y sales del mismo farmacéuticamente admisibles, en donde Rp es hidrógeno o grupo protector de hidroxi; R1 es, independientemente, hidrógeno o hidroxi en cada acontecimiento; y R2 es un radical hidrocarburo saturado C1-C8 de cadena lineal o ramificada; el método comprendiendo las etapas de: (a) tratar un compuesto representado por la fórmula: con un grupo protector de hidroxi y cloroformiato de 1-cloroetilo para proporcionar el compuesto de fórmula: **(Fórmula)**.

公开(公告)号：AU1413399A

公开(公告)日：1999-06-07

申请号：AU1413399

申请日：1998-11-17

Applicant: ABBOTT LAB

Inventor： HENGEVELD JOHN E ,  DONG XIAOXING ,  GUPTA ASHOK K ,  COPP RICHARD R JR ,  PREMCHANDRAN RAMIYA H

IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

Abstract: Disclosed is an improved and efficient process for N-desmethylating the 3'-amino nitrogen of erythromycins and for converting the 3'-N-desmethylated erythromycins into 3'-N-substituted derivatives of 8,9-anhydro-erythromycin 6,9-hemiketals.

公开(公告)号：DE69822870T2

公开(公告)日：2005-03-17

申请号：DE69822870

申请日：1998-11-17

Applicant: ABBOTT LAB

Inventor： HENGEVELD E ,  DONG XIAOXING ,  GUPTA K ,  COPP R ,  PREMCHANDRAN H

IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

Abstract: Disclosed is an improved and efficient process for N-desmethylating the 3'-amino nitrogen of erythromycins and for converting the 3'-N-desmethylated erythromycins into 3'-N-substituted derivatives of 8,9-anhydro-erythromycin 6,9-hemiketals.

公开(公告)号：DE69822870D1

公开(公告)日：2004-05-06

申请号：DE69822870

申请日：1998-11-17

Applicant: ABBOTT LAB

Inventor： HENGEVELD E ,  DONG XIAOXING ,  GUPTA K ,  COPP R ,  PREMCHANDRAN H

IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

Abstract: Disclosed is an improved and efficient process for N-desmethylating the 3'-amino nitrogen of erythromycins and for converting the 3'-N-desmethylated erythromycins into 3'-N-substituted derivatives of 8,9-anhydro-erythromycin 6,9-hemiketals.

公开(公告)号：AT263180T

公开(公告)日：2004-04-15

申请号：AT98958010

申请日：1998-11-17

Applicant: ABBOTT LAB

Inventor： HENGEVELD JOHN E ,  DONG XIAOXING ,  GUPTA ASHOK K ,  COPP RICHARD R JR ,  PREMCHANDRAN RAMIYA H

IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

Abstract: Disclosed is an improved and efficient process for N-desmethylating the 3'-amino nitrogen of erythromycins and for converting the 3'-N-desmethylated erythromycins into 3'-N-substituted derivatives of 8,9-anhydro-erythromycin 6,9-hemiketals.

公开(公告)号：CA2309255C

公开(公告)日：2008-05-20

申请号：CA2309255

申请日：1998-11-17

Applicant: ABBOTT LAB

Inventor： DONG XIAOXING ,  COPP RICHARD R JR ,  HENGEVELD JOHN E ,  PREMCHANDRAN RAMIYA H ,  GUPTA ASHOK K

IPC: C07H17/08 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04

Abstract: Disclosed is an improved and efficient process for N-desmethylating the 3'- amino nitrogen of erythromycins and for converting the 3'-N-desmethylated erythromycins into 3'-N-substituted derivatives of 8,9- anhydro-erythromycin 6,9-hemiketals.

公开(公告)号：DK1032580T3

公开(公告)日：2004-08-02

申请号：DK98958010

申请日：1998-11-17

Applicant: ABBOTT LAB

Inventor： HENGEVELD JOHN E ,  DONG XIAOXING ,  GUPTA ASHOK K ,  COPP RICHARD R JR ,  PREMCHANDRAN RAMIYA H

IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

Abstract: Disclosed is an improved and efficient process for N-desmethylating the 3'-amino nitrogen of erythromycins and for converting the 3'-N-desmethylated erythromycins into 3'-N-substituted derivatives of 8,9-anhydro-erythromycin 6,9-hemiketals.

公开(公告)号：CA2309255A1

公开(公告)日：1999-05-27

申请号：CA2309255

申请日：1998-11-17

Applicant: ABBOTT LAB

Inventor： GUPTA ASHOK K ,  PREMCHANDRAN RAMIYA H ,  HENGEVELD JOHN E ,  DONG XIAOXING ,  COPP RICHARD R JR

IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

Abstract: Disclosed is an improved and efficient process for N-desmethylating the 3'amino nitrogen of erythromycins and for converting the 3'-N-desmethylated erythromycins into 3'-N-substituted derivatives of 8,9-anhydro-erythromycin 6,9-hemiketals.