公开(公告)号：CA2661898A1

公开(公告)日：2008-02-28

申请号：CA2661898

申请日：2007-08-24

Applicant: ABBOTT LAB

Inventor： LEE CHIH-HUNG ,  BROWN BRIAN S ,  DARBYSHIRE JOHN ,  PERNER RICHARD J

IPC: C07D231/56 ,  A61K31/416 ,  A61P25/00

Abstract: Compounds of formula (I) wherein R3, R7, R9 and L are defined in the desc ription are TRPV1 antagonists that exhibit low inhibitory activity against C YP3A4. Compositions comprising such compounds and methods for treating condi tions and disorders using such compounds and compositions are also disclosed .

公开(公告)号：AT553093T

公开(公告)日：2012-04-15

申请号：AT07814410

申请日：2007-08-24

Applicant: ABBOTT LAB

Inventor： LEE CHIH-HUNG ,  BROWN BRIAN ,  PERNER RICHARD ,  DARBYSHIRE JOHN

IPC: C07D231/56 ,  A61K31/416 ,  A61P25/00

Abstract: Compounds of formula (I) wherein R3, R7, R9 and L are defined in the description are TRPV1 antagonists that exhibit low inhibitory activity against CYP3A4. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

公开(公告)号：MX2009002018A

公开(公告)日：2009-03-05

申请号：MX2009002018

申请日：2007-08-24

Applicant: ABBOTT LAB

Inventor： BROWN BRIAN S ,  PERNER RICHARD J ,  LEE CHIH-HUNG ,  DARBYSHIRE JOHN

IPC: A61K31/416 ,  C07D231/56 ,  A61P25/00

Abstract: Se describen compuestos de la fórmula (I), en donde R3, R7, R9 y L se definen en la descripción, los cuales con antagonistas de TRPV1 que exhiben baja actividad inhibidora contra CYP3A4. También se describen composiciones que comprenden dichos compuestos y métodos para trata condiciones y trastornos utilizando dichos compuestos y composiciones.