公开(公告)号：SE302135B

公开(公告)日：1968-07-08

申请号：SE646562

申请日：1962-06-08

Applicant: ABBOTT LAB

Inventor： ZAUGG H ,  DE NET R ,  MICHAELS R

IPC: C07D499/00 ,  C07D5/36

公开(公告)号：SE301985B

公开(公告)日：1968-07-01

申请号：SE646462

申请日：1962-06-08

Applicant: ABBOTT LAB

Inventor： ZAUGG H ,  DE NET R ,  MICHAELS R

IPC: C07D311/58 ,  C07D313/08 ,  C07D451/10 ,  C07D5/36

Abstract: The invention comprises compounds of the general formula (wherein n is 1, 2 or 3, X is oxygen or sulphur and R is -CH2CH2N(C2H5)2 -CH2CH2N(CH3)2 CH2CH2N[CH(CH3)2]2 -CH(CH3)CH2N(CH3)2 or 3-a -tropanyl) and non-toxic acid addition salts thereof, pharmaceutical preparations containing them, and their preparation by (a) reacting equimolecular proportions of a compound of the formula with RXH in the presence of an hydrogen chloride acceptor at from room temperature to the boiling temperature of the reaction mixture; or (b)-in the case of compounds, wherein X represents oxygen-reacting equimolecular proportions of a compound of the formula (wherein Hal is chlorine or bromine) with MOR (wherein M is hydrogen or an alkali metal) in the presence of a hydrogen halide acceptor at from room temperature to the boiling temperature of the reaction mixture, optionally followed in either case by acid addition salt formation. The compounds of the invention are analgesics, hypotensive agents, local anaesthetics and antispasmodics, and may be administered orally, intravenously or intramuscularly in the form of pharmaceutical preparations (e.g. tablets, solutions, suspensions and emulsions) containing them together with a carrier.