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    PROCESS FOR PREPARING 2-SUBSTITUTED-5-ALKYL RESORCINOLS
    1.
    发明授权
    PROCESS FOR PREPARING 2-SUBSTITUTED-5-ALKYL RESORCINOLS 失效

    公开(公告)号：KR800000905B1

    公开(公告)日：1980-09-10

    申请号：KR760002838

    申请日：1976-11-13

    Applicant: ABBOTT LAB

    Inventor： LEE CHUK MAN ,  ZAUGG H ,  PLOTNIKOFF N ,  MICHAELS R

    IPC: C07D213/30 ,  C07D213/55

    Abstract: The title compds. (I; R1=H, lower alkanoyl; R2=C1-20 straight or side chain alkyl; X=nitrogen or C-methyl), useful as analgesics, were prepd. by reaction of liquid ammonia and isopropenyl derivs. (IV) obtained from dehydration of diacetyl deriv. with thionyl chloride. Diacetyl deriv. was prepared by reaction of anhydrous acetic acid and alcohol(III) obtained from benzopyranone(II) and methyl magnesium bromide in tetrahydrofuran.

    3.
    发明专利
    未知

    公开(公告)号：BR6239734D0

    公开(公告)日：1973-05-24

    申请号：BR13973462

    申请日：1962-06-07

    Applicant: ABBOTT LAB

    Inventor： MICHAELS R ,  ZANGG H ,  DENET R

    IPC: C07D311/58 ,  C07D313/08 ,  C07D451/10

    Abstract: The invention comprises compounds of the general formula (wherein n is 1, 2 or 3, X is oxygen or sulphur and R is -CH2CH2N(C2H5)2 -CH2CH2N(CH3)2 CH2CH2N[CH(CH3)2]2 -CH(CH3)CH2N(CH3)2 or 3-a -tropanyl) and non-toxic acid addition salts thereof, pharmaceutical preparations containing them, and their preparation by (a) reacting equimolecular proportions of a compound of the formula with RXH in the presence of an hydrogen chloride acceptor at from room temperature to the boiling temperature of the reaction mixture; or (b)-in the case of compounds, wherein X represents oxygen-reacting equimolecular proportions of a compound of the formula (wherein Hal is chlorine or bromine) with MOR (wherein M is hydrogen or an alkali metal) in the presence of a hydrogen halide acceptor at from room temperature to the boiling temperature of the reaction mixture, optionally followed in either case by acid addition salt formation. The compounds of the invention are analgesics, hypotensive agents, local anaesthetics and antispasmodics, and may be administered orally, intravenously or intramuscularly in the form of pharmaceutical preparations (e.g. tablets, solutions, suspensions and emulsions) containing them together with a carrier.

    7.
    发明专利
    未知

    公开(公告)号：SE301985B

    公开(公告)日：1968-07-01

    申请号：SE646462

    申请日：1962-06-08

    Applicant: ABBOTT LAB

    Inventor： ZAUGG H ,  DE NET R ,  MICHAELS R

    IPC: C07D311/58 ,  C07D313/08 ,  C07D451/10 ,  C07D5/36

    Abstract: The invention comprises compounds of the general formula (wherein n is 1, 2 or 3, X is oxygen or sulphur and R is -CH2CH2N(C2H5)2 -CH2CH2N(CH3)2 CH2CH2N[CH(CH3)2]2 -CH(CH3)CH2N(CH3)2 or 3-a -tropanyl) and non-toxic acid addition salts thereof, pharmaceutical preparations containing them, and their preparation by (a) reacting equimolecular proportions of a compound of the formula with RXH in the presence of an hydrogen chloride acceptor at from room temperature to the boiling temperature of the reaction mixture; or (b)-in the case of compounds, wherein X represents oxygen-reacting equimolecular proportions of a compound of the formula (wherein Hal is chlorine or bromine) with MOR (wherein M is hydrogen or an alkali metal) in the presence of a hydrogen halide acceptor at from room temperature to the boiling temperature of the reaction mixture, optionally followed in either case by acid addition salt formation. The compounds of the invention are analgesics, hypotensive agents, local anaesthetics and antispasmodics, and may be administered orally, intravenously or intramuscularly in the form of pharmaceutical preparations (e.g. tablets, solutions, suspensions and emulsions) containing them together with a carrier.

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