公开(公告)号：US3558600A

公开(公告)日：1971-01-26

申请号：US3558600D

申请日：1967-07-28

Applicant: ABBOTT LAB

Inventor： GEISZLER ADOLPH OSCAR ,  JONES PETER HADLEY

IPC: A61K45/00 ,  C07D243/08 ,  C07D53/02

CPC classification number: C07C305/00 ,  Y10S514/929

Abstract: NOVEL LONG CHAIN ALKYL SULFATE SALTS OF 1-(P-CHLOROBENZHYDRYL)-4-METHYLHOMOPIPERAZINE ARE DISCLOSED. THESE SALT FORMS MASK THE BITTER TASTE ASSOCIATED WITH THE FREE BASE AND SOLUBLE ACID-ADDITION SALT FORMS OF THIS COMPOUND THEREBY ENABLING THE PREPARATION OF AN ORAL DOSAGE FORM OF THIS ANTIHISTAMINIC AND BRONCHODILATING AGENT.

公开(公告)号：DE2330556A1

公开(公告)日：1974-01-10

申请号：DE2330556

申请日：1973-06-15

Applicant: ABBOTT LAB

Inventor： GEISZLER ADOLPH OSCAR

IPC: C07D295/10 ,  A61K31/495 ,  A61P33/00 ,  A61P33/10 ,  C07D295/073 ,  C07D295/096 ,  C07D295/112 ,  C07D295/185 ,  C07D51/70

公开(公告)号：DE2327692A1

公开(公告)日：1973-12-13

申请号：DE2327692

申请日：1973-05-30

Applicant: ABBOTT LAB

Inventor： LEE CHEUK MAN ,  GEISZLER ADOLPH OSCAR

IPC: C07D263/48 ,  C07D85/40

公开(公告)号：DE2445752A1

公开(公告)日：1975-04-03

申请号：DE2445752

申请日：1974-09-25

Applicant: ABBOTT LAB

Inventor： DUNNIGAN DANIEL AMBROSE ,  GEISZLER ADOLPH OSCAR ,  HOLLAND JAMES BROOKS

IPC: C07C217/74 ,  A61K31/13 ,  A61K31/135 ,  C07C67/00 ,  C07C213/00 ,  C07C93/14

Abstract: Covers a compound selected from the group consisting of a member of the formula: wherein R1 is a radial selected from the group consisting of higher branched or straight chain alkyl and cycloalkyl radicals wherein said R1 radical contains at least six carbon atoms, R2 is a radical selected from the group consisting of hydrogen, loweralkyl and loweralkanol radicals, wherein said R2 radical contains 1 - 3 carbon atoms, and R3 is methoxy; and nontoxic pharmaceutically acceptable acid addition salts thereof. Also covers the use of said compound as a local anesthetic and pharmaceutical compositions comprising said above compounds as the active ingredient.

公开(公告)号：AU5513573A

公开(公告)日：1974-11-07

申请号：AU5513573

申请日：1973-05-02

Applicant: ABBOTT LAB

Inventor： GEISZLER ADOLPH OSCAR ,  LEE CHEUK MAN

IPC: C07D263/48 ,  A61K27/00 ,  C07D85/40

公开(公告)号：AU5559973A

公开(公告)日：1974-11-14

申请号：AU5559973

申请日：1973-05-11

Applicant: ABBOTT LAB

Inventor： GEISZLER ADOLPH OSCAR

IPC: C07D295/10 ,  A61K31/495 ,  A61P33/00 ,  A61P33/10 ,  C07D295/073 ,  C07D295/096 ,  C07D295/112 ,  C07D295/185 ,  C07D51/70 ,  A61K27/00

公开(公告)号：BE575225A

公开(公告)日：1959-05-15

申请号：BE575225

申请日：1959-01-29

Applicant: ABBOTT LAB

Inventor： ZAUGG HAROLD ELMER ,  GEISZLER ADOLPH OSCAR ,  GARVEN FLOYD CHARLES ,  HAMLIN KENNETH ELDRED

IPC: C07C69/38 ,  C07B