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    2-propargylamino-5-phenyl-2-oxazolin-4-one and derivatives
    1.
    发明授权
    2-propargylamino-5-phenyl-2-oxazolin-4-one and derivatives 失效
    2-丙酰氨基-5-苯基-2-氧杂环戊烯-4-酮和衍生物

    公开(公告)号：US3578672A

    公开(公告)日：1971-05-11

    申请号：US3578672D

    申请日：1969-11-03

    Applicant: ABBOTT LAB

    Inventor： LEE CHEUK MAN ,  HORROM BRUCE WAYNE

    IPC: C07D263/48 ,  C07D85/40

    CPC classification number: C07D263/48

    Abstract: 2-PROPARGYLAMINO-5-PHENYL-2-OXAZOLINE-4-ONE AND DERIVATIVES THEREOF WERE FOUND TO BE EFFECTIVE ANTI-DEPRESSANTS WHEN ADMINISTERED IN ORAL DOSAGES OF 0.5-20 MG./KG. TO WARM-BLOODED ANIMALS. THE NEW COMPOUNDS ARE PREPARED BY CONDENSING 2-AMINO-5-PHENYL-2-OXAZOLIN-4-ONE WITH PROPARGYLAMINE OR THE CORRESPONDING N- AND/OR 1-MONOOR DISUBSTITUTED ALKYL DERIVATIVES THEREOF IN THE PRESENCE OR ABSENCE OF AN INERT REACTION MEDIUM.

    Certain pyridylalkyl derivatives of 2-amino-5-phenyl-2-oxazolin-4-ones
    2.
    发明授权
    Certain pyridylalkyl derivatives of 2-amino-5-phenyl-2-oxazolin-4-ones 失效
    2-氨基-5-苯基-2-氧杂环己烷-4-酮的某些吡啶基亚胺衍生物

    公开(公告)号：US3681367A

    公开(公告)日：1972-08-01

    申请号：US3681367D

    申请日：1970-09-25

    Applicant: ABBOTT LAB

    Inventor： LEE CHEUK MAN

    IPC: C07D413/12 ,  C07D31/44

    CPC classification number: C07D413/12

    Abstract: 2-Pyridylalkylamino-5-phenyl-2-oxazolin-4-ones with optional simple substituents in the phenyl ring or in the connecting alkylamino bridge between the two heterocyclic rings were found to be valuable anti-depressants when administered orally to warmblooded animals.

    Abstract translation: 当在温血动物口服给药时，在苯环或两个杂环之间的连接烷基氨基桥中具有任选简单取代基的2-吡啶基烷基氨基-5-苯基-2-恶唑啉-4-酮被发现是有价值的抗抑郁剂 。

    Basic carbonates and carbamates of benzopyrans
    3.
    发明授权
    Basic carbonates and carbamates of benzopyrans 失效
    苯并吡喃的碱性碳酸酯和氨基甲酸酯

    公开(公告)号：US3927036A

    公开(公告)日：1975-12-16

    申请号：US25695472

    申请日：1972-05-25

    Applicant: ABBOTT LAB

    Inventor： LEE CHEUK MAN

    IPC: C07D311/80 ,  C07D311/94

    CPC classification number: C07D311/80 ,  C07D311/94

    Abstract: WHEREIN N IS 1 OR 2; R1 is hydrogen or loweralkyl; R2 is loweralkyl; R3 is alkyl or cycloalkyl; X is O or NH; y is an integer from 2-6; and R4 and R5 each are hydrogen or loweralkyl; or R4 and R5 taken together form a 5- or 6-membered heterocyclic ring and the acid addition salts thereof.

    Basic carbonates and carbamates of benzopyrans represented by the formula

    Abstract translation: 由式WHEREIN N IS 1 OR 2表示的苯并吡喃的碱性碳酸酯和氨基甲酸酯; R1是氢或低级烷基; R2是低级烷基; R3是烷基或环烷基; X是O或NH; y是2-6的整数; 并且R 4和R 5各自为氢或低级烷基; 或R 4和R 5一起形成5或6元杂环及其酸加成盐。

    5H-{8 1{9 benzopyrano{8 3,4-d{9 pyridines
    4.
    发明授权
    5H-{8 1{9 benzopyrano{8 3,4-d{9 pyridines 失效
    5H- {8 1 {9苯并吡喃并[8,3-d {9吡啶

    公开(公告)号：US3878219A

    公开(公告)日：1975-04-15

    申请号：US37901673

    申请日：1973-07-13

    Applicant: ABBOTT LAB

    Inventor： LEE CHEUK MAN

    IPC: C07D20060101 ,  C07D31/34

    Abstract: X is a straight or branched chain alkylene group having from 1 to 8 carbon atoms, and wherein R7 and R8 are the same or different members of the group consisting of hydrogen or loweralkyl, or
    5H-(1)Benzopyrano(3,4-d)pyridines represented by the formula

    WHEREIN EACH R1 is loweralkyl, R2 is alkyl, cycloalkyl or

    WHEREIN Y is a straight or branched chain alkylene group having from 1 to 10 carbon atoms and each R4, R5 and R6 are the same or different members of the group consisting of hydrogen, halo, trifluoromethyl or loweralkyl; and R3 is hydroxy, acyloxy or

    D R A W I N G
    WHEREIN X is a straight or branched chain alkylene group having from 1 to 8 carbon atoms, a is an integer from 1 to 4, b is an integer from 1 to 4, Z is CH2, O, S or NR10 with R10 being hydrogen or loweralkyl, with the limitation that when Z is O or S, the sum of a and b is 3 or 4; and when Z is NR10, the sum of a and b is 3-5; R9 is hydrogen or loweralkyl, and the pharmaceutically acceptable salts thereof.

    Abstract translation: 5H- [1]由式XI表示的苯并吡喃并[3,4-d]吡啶是低级烷基，R 2是烷基，环烷基或者WHEREIN Y是具有1至10个碳原子的直链或支链亚烷基，每个R 4 ，R5和R6是由氢，卤素，三氟甲基或低级烷基组成的组中相同或不同的成员; 并且R 3是羟基，酰氧基或X是具有1至8个碳原子的直链或支链亚烷基，并且其中R 7和R 8是由氢或低级烷基组成的组的相同或不同的成员，或者WHEREIN X是直链 或具有1至8个碳原子的支链亚烷基，a是1至4的整数，b是1至4的整数，Z是CH 2，O，S或NR 10，其中R 10是氢或低级烷基，其限制 当Z为O或S时，a和b之和为3或4; 当Z为NR10时，a和b之和为3-5; R9是氢或低级烷基，及其药学上可接受的盐。

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