公开(公告)号：US3714142A

公开(公告)日：1973-01-30

申请号：US3714142D

申请日：1971-01-18

Applicant: ABBOTT LAB

Inventor： MARTIN J ,  GOLDSTEIN A

IPC: C07H17/08 ,  C07G11/00

CPC classification number: C07H17/08 ,  Y10S435/886

Abstract: Erythromycin E is useful as an antibiotic. The compounds is prepared by the fermentation of erythromycin with Streptomyces erythreus NRRL 3887 in suitable nutrient media.

Abstract translation: 红霉素E可用作抗生素。 通过在合适的营养培养基中将红霉素与红链霉菌NRRL 3887发酵来制备化合物。

公开(公告)号：US3801465A

公开(公告)日：1974-04-02

申请号：US3801465D

申请日：1973-01-22

Applicant: ABBOTT LAB

Inventor： MARTIN J ,  GOLDSTEIN A

IPC: C07H17/08 ,  C12D9/00

CPC classification number: C07H17/08 ,  Y10S435/849 ,  Y10S435/852 ,  Y10S435/866 ,  Y10S435/873 ,  Y10S435/874 ,  Y10S435/883 ,  Y10S435/886 ,  Y10S435/947 ,  Y10S435/948

Abstract: Erythromycin E is useful as an antibiotic. The compound is prepared by the fermentation of erythromycin with Streptomyces erythreus NRRL 3887 in suitable nutrient media.

公开(公告)号：SE310632B

公开(公告)日：1969-05-12

申请号：SE531261

申请日：1961-05-19

Applicant: ABBOTT LAB

Inventor： GOLDSTEIN A

IPC: C12P17/18 ,  C12P17/06

Abstract: A fermented culture medium containing antimicrobial agent M-141 is obtained by cultivating the micro-organism streptomyces flavopersicus especially S. flavopersicus NRRL 2820 under submerged aerobic conditions in an aqueous culture medium containing assimilable sources of carbohydrates, nitrogen and inorganic salts, preferably at 24-32 DEG C. for a period of 1-5 days. The antimicrobial agent M-141 is recovered from the clarified culture medium in the form of its acid addition salts by adsorbtion on a cation exchange resin and elution of the adsorbate. Carboxylic and sulphonic type cation exchange resins are mentioned. The acid addition salts of antimicrobial agent M-141 which is a nitrogenous base are characterised in that the hydrochloride of said base has the following properties:-soluble in water and methanol, but insoluble in acetone, chloroform and diethyl ether; no characteristic U.V. spectrum; an I.R. spectrum in hydrocarbon oil as shown in the drawing; [a ]25D of 25 (c=1 in water); an empirical formula C14H38O12N2C12; an elemental analysi C= 34.03%, H=7.46%, O=38.83%, N=5.56% and C1=19.1% and loss on drying of 19.1%; mol.wt. by titration of 420; Pka values of about 7.0 and 9.0 when titrated in water which change to about 5 and 7.5 when titrated in 4% aqueous formaldehyde solution and a melting point of 210 DEG C. Specified salts are the chloride and the sulphate. The hydrochloride mixed with chicken feed is used as a veterinary preparation to cure coccidioris.