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    8-epi-erythromycins
    1.
    发明授权
    8-epi-erythromycins 失效
    8-EPI-ERYTHROMYCINS

    公开(公告)号：US3842068A

    公开(公告)日：1974-10-15

    申请号：US26308872

    申请日：1972-06-15

    Applicant: ABBOTT LAB

    Inventor： TADANIER J ,  MARTIN J

    IPC: C07H17/08 ,  C07C47/18

    CPC classification number: C07H17/08

    Abstract: 1. AN ERYTHROMYCIN DERIVATIVE SELECTED FROM THE GROUP CONSISTING OF 8-EPI-10,11-ANHYDROETHYTHROMYCN B, 8-EPI11, 12-EPOXYERYTHROMYCIN A 6,9-HEMIACETAL, 8-EPI-ERYTHROMYCIN B AND 8-EPI-10,11-ANHYDROERYTHROMYCIN A.

    "> 4
    4.
    发明授权
    4"-deoxy-4"-oxoerythromycin b derivatives 失效
    4“-DEOXY-4” - 紫罗兰霉素B衍生物

    公开(公告)号：US3842069A

    公开(公告)日：1974-10-15

    申请号：US37238773

    申请日：1973-06-21

    Applicant: ABBOTT LAB

    Inventor： JONES P ,  MARTIN J ,  TADANIER J ,  MCALPINE J ,  PAUVLIK J

    IPC: C07H17/08 ,  C07C129/18

    CPC classification number: C07H17/08

    Abstract: 1. A 4"-DEOXY-4"-OXOERYTHROMYCIN COMPOUND SELECTED FROM THE GROUP CONSISTING OF

    2,10-DI(O=),4,5,7,9,11,13,-HEXA(H3C-),4-((4,6-DI(H3C-),

    4-(H3C-O-),5-(O=),6-(H3C-)-TETRAHYDROPYR-2-YL)-O-),6-

    ((3-(R1-O-),4-((H3C)2-N-),6-(H3C-)-TETRAHYDROPYR-2-YL)-

    O-),7-(HO-),12-(R-O-),14-(H5C2-)-OXACYCLOTETRADECANE

    WHERE R IS -CHR2SR3 WHERE R'' IS HYDROGEN OR LOWERALKYL, R3 IS LOWERALKYL AND R1 IS HYDROGEN OR LOWERALKANOYL AND;

    2-(O=),3,5,7,9,11,13-HEXA(H3C-),4-((4,6-DI(H3C-),

    4-(H3C-O-),5-(O=),6-(H3C-)-TETRAHYDROPYR-2-YL)-O-),6-

    ((3-(R1-O-),4-((H3C)2-N-),6-(H3C-)-TETRAHYDROPYR-2-YL)-

    O-),7,10-(-O-),10,12-(-O-CH(-R2)-O-),12-(H5C2-)-

    OXACYCLOTETRADECANE

    WHERE R1 AND R2 ARE AS BEFORE DEFINED.

    Antipyretic agent
    6.
    发明授权
    Antipyretic agent 失效
    抗菌剂

    公开(公告)号：US3740425A

    公开(公告)日：1973-06-19

    申请号：US3740425D

    申请日：1972-03-09

    Applicant: ABBOTT LAB

    Inventor： MARTIN J

    IPC: C07H17/08 ,  A61K21/00

    CPC classification number: C07H17/08

    Abstract: 3-O-(A-L-MYCAROSYL)-8-HYDROXYERYTHRONOLIDE B IS USEA PHARMACOLOGICALLY ACTIVE SUBSTANCE HAVING BLOOD FUL AS AN ANTIPYRETIC AGENT. THE COMPOUND IS PREPARED BY THE FERMENATION OF 8-HYDROXYERYTHRONOLIDE B WITH STREPTOMYCES ERYTHREUS NRRL 3887 IN SUITABLE NUTRIENT MEDIA.

    Erythromycine
    8.
    发明授权
    Erythromycine 失效
    红霉素

    公开(公告)号：US3714142A

    公开(公告)日：1973-01-30

    申请号：US3714142D

    申请日：1971-01-18

    Applicant: ABBOTT LAB

    Inventor： MARTIN J ,  GOLDSTEIN A

    IPC: C07H17/08 ,  C07G11/00

    CPC classification number: C07H17/08 ,  Y10S435/886

    Abstract: Erythromycin E is useful as an antibiotic. The compounds is prepared by the fermentation of erythromycin with Streptomyces erythreus NRRL 3887 in suitable nutrient media.

    Abstract translation: 红霉素E可用作抗生素。 通过在合适的营养培养基中将红霉素与红链霉菌NRRL 3887发酵来制备化合物。

    Sulfonyl derivatives of erythromycin
    9.
    发明授权
    Sulfonyl derivatives of erythromycin 失效
    红霉素的磺酰衍生物

    公开(公告)号：US3836519A

    公开(公告)日：1974-09-17

    申请号：US35712173

    申请日：1973-05-04

    Applicant: ABBOTT LAB

    Inventor： HALLAS R ,  MARTIN J ,  TADANIER J

    IPC: A61K31/335 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  C07C129/18

    CPC classification number: C07H17/08

    Abstract: COVERS SULFONYL DERIVATIVES OF ERHYTHROMYCIN A, B AND C FALLING WITHIN THE FOLLOWING STRUCTURAL FORMULA:

    3,5,7,9,11,13-HEXA(H3C-),4-((2,4-DI(H3C-),3-(R-SO2-O-),

    4-(R1O-)-TETRAHYDROPYRAN-6-YL)-O-),6-((2-(H3C-),

    4-(N(-CH3)2-),5-(R2O-)-TETRAHYDROPYRAN-6-YL)-O-),7,12-

    DI(HO-),13-R3,14-(H5C2-)-OXACYCLOTETRADECANE-2,10-DIONE

    WHERE R IS SELECTED FROM THE ROUP CONSISTING OF LOWERALKYL, LOWERALKENYL, ARYL, SUBSTITUTED ARYL, BENZYL, SUBSTITUTED BENZYL, AROXYALKYL, AND SUBSTITUTED AROXYALKYL; R1 IS HYDROGEN OR METHYL; R2 IS HYDROGEN OR LOWERAKNANOYL AND R3 IS HYDROGEN OR HYDROXYL SAID ERYTHROMYCIN DERIVATIVES BEING USEFUL FOR THIER ANTIBIOTIC ACTIVITY.

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