公开(公告)号：SI0984975T1

公开(公告)日：2004-02-29

申请号：SI9830449

申请日：1998-05-22

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  GRIESGRABER GEORGE W ,  CHU DANIEL T

IPC: A61K31/70 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

Abstract: Novel multicyclic erythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formulae (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX), (X), or (XI), pharmaceutical compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of formula (I).

公开(公告)号：PT984975E

公开(公告)日：2003-09-30

申请号：PT98923678

申请日：1998-05-22

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  GRIESGRABER GEORGE W ,  CHU DANIEL T

IPC: A61K31/70 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

Abstract: Novel multicyclic erythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formulae (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX), (X), or (XI), pharmaceutical compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of formula (I).

公开(公告)号：NO995842D0

公开(公告)日：1999-11-29

申请号：NO995842

申请日：1999-11-29

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  GRIESGRABER GEORGE W ,  CHU DANIEL T

IPC: A61K31/70 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  C07H

Abstract: Novel multicyclic erythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formulae (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX), (X), or (XI), pharmaceutical compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of formula (I).

公开(公告)号：AU7591298A

公开(公告)日：1998-12-30

申请号：AU7591298

申请日：1998-05-22

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  GRIESGRABER GEORGE W ,  CHU DANIEL T

IPC: A61K31/70 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

Abstract: Novel multicyclic erythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formulae (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX), (X), or (XI), pharmaceutical compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of formula (I).

公开(公告)号：CA2290421C

公开(公告)日：2007-05-08

申请号：CA2290421

申请日：1998-05-22

Applicant: ABBOTT LAB

Inventor： CHU DANIEL T ,  OR YAT SUN ,  GRIESGRABER GEORGE W

IPC: C07H17/08 ,  A61K31/70 ,  A61K31/7048 ,  A61P31/04

Abstract: Novel multicyclic erythromycin compounds and pharmaceutically acceptable sal ts and esters thereof having antibacterial activity having formulae (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX), (X), or (XI), pharmaceutical compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of formula (I).

公开(公告)号：DK0922050T3

公开(公告)日：2003-11-24

申请号：DK97921411

申请日：1997-04-25

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  CHU DANIEL T ,  GRIESGRABER GEORGE W ,  PLATTNER JACOB J ,  PIREH DAISY ,  ELLIOTT RICHARD L

IPC: A61K31/04 ,  A61K31/70 ,  A61K31/7048 ,  A61K31/7052 ,  C07H17/08

Abstract: Novel 3-descladinose-2,3-anhydroerythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity selected from the group consisting of: (a) (I), (b) (II), (c) (III), and (d) (IV), pharmaceutical compositions comprising a therapeutically effective amount of a compound of formulas (I)-(IV) of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of formulas (I)-(IV) of the invention.

公开(公告)号：NZ332321A

公开(公告)日：2000-04-28

申请号：NZ33232197

申请日：1997-04-25

Applicant: ABBOTT LAB

Inventor： ELLIOTT RICHARD L ,  OR YAT SUN ,  CHU DANIEL T ,  GRIESGRABER GEORGE W ,  PLATTNER JACOB J ,  PIREH DAISY

IPC: A61K31/04 ,  A61K31/70 ,  A61K31/7048 ,  A61K31/7052 ,  C07H17/08

Abstract: A compound or pharmaceutically acceptable salt or ester thereof selected from the formulae I, II, III and IV is claimed wherein: R1 is -H, -OH, -O-alkyl, -O-CO-alkyl, -O-CO-NH2, -O-CO-NH-CO-alkyl, -O-CO-NH-SO2-alkyl; R2 is H or a hydroxyl-protecting group; R6 is H or alkyl; R is H, optionally substituted alkyl, cycloalkyl or optionally substituted aryl or heteroaryl; W is absent or is -O-, -NH-CO-, -N=CH-, -NH- or -N-alkyl-; A, B, D and E are independently H, optionally substituted alkyl, cycloalkyl or optionally substituted aryl or heteroaryl, heterocycloalkyl or a group listed under option (b) as defined in the specification further substituted by -M-R5 or AB, AD, AE, BD, BE or DE can be taken together with the atom(s) to form a 3-7 membered ring optionally containing a heteroatom(s) as defined in the specification. A pharmaceutical composition containing a compound as defined above useful in treating bacteria infections is claimed.

公开(公告)号：CZ9904073A3

公开(公告)日：2000-02-16

申请号：CZ407399

申请日：1998-05-22

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  GRIESGRABER GEORGE W ,  CHU DANIEL T

IPC: A61K31/7048 ,  A61P31/04 ,  C07H17/08

公开(公告)号：ZA984488B

公开(公告)日：1998-12-02

申请号：ZA984488

申请日：1998-05-26

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  GRIESGRABER GEORGE W ,  CHU DANIEL T

IPC: A61K31/70 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  C07D ,  A61K

Abstract: Novel multicyclic erythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formulae (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX), (X), or (XI), pharmaceutical compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of formula (I).

公开(公告)号：ZA973409B

公开(公告)日：1997-11-18

申请号：ZA973409

申请日：1997-04-21

Applicant: ABBOTT LAB

Inventor： ELLIOTT RICHARD L ,  CHU DANIEL T ,  PLATTNER JACOB J ,  OR YAT SUN ,  GRIESGRABER GEORGE W ,  PIREH DAISY

IPC: A61K20060101 ,  C07D20060101 ,  C07D ,  A61K