公开(公告)号：ZA9709728B

公开(公告)日：1998-05-22

申请号：ZA9709728

申请日：1997-10-29

Applicant: ABBOTT LAB

Inventor： WANG WEI-BO ,  LI QUN ,  CHU DANIEL T ,  HASVOLD LISA ANNE

IPC: C07D207/14 ,  C07D455/02 ,  C07D471/04 ,  C07D

CPC classification number: C07D207/14 ,  C07D455/02 ,  C07D471/04 ,  Y02P20/55

公开(公告)号：AU7300498A

公开(公告)日：1998-06-10

申请号：AU7300498

申请日：1997-11-18

Applicant: ABBOTT LAB

Inventor： WANG WEI-BO ,  LI QUN ,  CHU DANIEL T ,  HASVOLD LISA ANNE

IPC: C07D207/14 ,  C07D455/02 ,  C07D471/04 ,  C07D487/04

Abstract: A process for the preparation of chiral 3-aminopyrrolidine and analogous bicyclic derivatives from dihydroxy olefins by treatment with titanium isopropoxide, an optically active tartrate ester and tert-butyl hydroperoxide, followed by subsequent alkylation of the intermediate with an alkyl or alkenyl magnesium halide, then pyrrolidine ring formation by condensation with an arylmethylamine, subsequent chiral replacement of a ring hydroxyl group with an amino group with further protection thereof, optional additional substitution closing of the second ring, and hydrogenolysis to remove a ring-nitrogen protecting group.

公开(公告)号：ZA979728B

公开(公告)日：1998-05-22

申请号：ZA979728

申请日：1997-10-29

Applicant: ABBOTT LAB

Inventor： WANG WEI-BO ,  LI QUN ,  CHU DANIEL T ,  HASVOLD LISA ANNE

IPC: C07D207/14 ,  C07D455/02 ,  C07D471/04 ,  C07D

Abstract: A process for the preparation of chiral 3-aminopyrrolidine and analogous bicyclic derivatives from dihydroxy olefins by treatment with titanium isopropoxide, an optically active tartrate ester and tert-butyl hydroperoxide, followed by subsequent alkylation of the intermediate with an alkyl or alkenyl magnesium halide, then pyrrolidine ring formation by condensation with an arylmethylamine, subsequent chiral replacement of a ring hydroxyl group with an amino group with further protection thereof, optional additional substitution closing of the second ring, and hydrogenolysis to remove a ring-nitrogen protecting group.