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    3.
    发明专利
    未知

    公开(公告)号：ES2168740T3

    公开(公告)日：2002-06-16

    申请号：ES98904979

    申请日：1998-02-06

    Applicant: ABBOTT LAB

    Inventor： WANG WEI-BO ,  KERDESKY FRANCIS A J ,  HSIAO CHI-NUNG W ,  LI QUN ,  CHU DANIEL T

    IPC: C07D455/02

    Abstract: A process for the preparation of a compound having the formula: wherein R1, R2, R3, R4, and R5 are defined, from an enamine by chain expansion and ring closure followed by additional derivatization, treatment with a 3-alkoxyl-acryloyl compound, another ring closure, and converting a hydroxyl group to a leaving group.

    Process for preparation of chiral 3-amino-pyrrolidine and analogous bicyclic compounds.
    6.
    发明专利
    Process for preparation of chiral 3-amino-pyrrolidine and analogous bicyclic compounds. 未知

    公开(公告)号：ZA979728B

    公开(公告)日：1998-05-22

    申请号：ZA979728

    申请日：1997-10-29

    Applicant: ABBOTT LAB

    Inventor： WANG WEI-BO ,  LI QUN ,  CHU DANIEL T ,  HASVOLD LISA ANNE

    IPC: C07D207/14 ,  C07D455/02 ,  C07D471/04 ,  C07D

    Abstract: A process for the preparation of chiral 3-aminopyrrolidine and analogous bicyclic derivatives from dihydroxy olefins by treatment with titanium isopropoxide, an optically active tartrate ester and tert-butyl hydroperoxide, followed by subsequent alkylation of the intermediate with an alkyl or alkenyl magnesium halide, then pyrrolidine ring formation by condensation with an arylmethylamine, subsequent chiral replacement of a ring hydroxyl group with an amino group with further protection thereof, optional additional substitution closing of the second ring, and hydrogenolysis to remove a ring-nitrogen protecting group.

    Process for preparing 4H-4-oxo-quinolizine-3-carboxylic acid derivatives
    7.
    发明专利
    Process for preparing 4H-4-oxo-quinolizine-3-carboxylic acid derivatives 未知

    公开(公告)号：CZ290252B6

    公开(公告)日：2002-06-12

    申请号：CZ288199

    申请日：1998-02-06

    Applicant: ABBOTT LAB

    Inventor： WANG WEI-BO ,  KERDESKY FRANCIS A J ,  HSIAO CHI-NUNG W ,  LI QUN ,  CHU DANIEL T

    IPC: C07D455/02

    Abstract: In the present invention there is disclosed a process for preparing carboxylic acid of the general formula II, in which the substituents Re1 through Re5 have specific meaning, by reacting enamine with acid chloride and further by reacting the resulting intermediate with malonamic acid ester in the presence of a base. Subsequently the obtained compound is protected on the hydroxy position by treatment thereof for example with methyl chloride. The resulting compound then reacts with an alkali metal base and subsequently with 3-alkoxyacryloyl compound and the formed intermediates is reacted with a catalytic amount of acid in order to close a ring and finally the resulting acid is reacted with a halogenating agent.

    9.
    发明专利
    未知

    公开(公告)号：TR199901956T2

    公开(公告)日：1999-10-21

    申请号：TR9901956

    申请日：1998-02-06

    Applicant: ABBOTT LAB

    Inventor： WANG WEI-BO ,  KERDESKY FRANCIS A J ,  HSIAO CHI-NUNG W ,  LI QUN ,  CHU DANIEL T

    IPC: C07D455/02

    Abstract: A process for the preparation of a compound having the formula: wherein R1, R2, R3, R4, and R5 are defined, from an enamine by chain expansion and ring closure followed by additional derivatization, treatment with a 3-alkoxyl-acryloyl compound, another ring closure, and converting a hydroxyl group to a leaving group.

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