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    N-vinyl oxyethyl-{60 -methyl-{62 -phenethylamines
    2.
    发明授权
    N-vinyl oxyethyl-{60 -methyl-{62 -phenethylamines 失效
    N-乙烯基氧乙基 - {60-甲基 - {62-苯乙胺

    公开(公告)号：US3925475A

    公开(公告)日：1975-12-09

    申请号：US49801374

    申请日：1974-08-16

    Applicant: ABBOTT LAB

    Inventor： HORROM BRUCE WAYNE

    IPC: C07C217/08 ,  A61K31/135 ,  C07C67/00 ,  C07C213/00 ,  C07C87/29

    CPC classification number: A61K31/135 ,  Y10S514/91

    Abstract: Novel N-vinyloxyethyl- Alpha -methyl- Beta -phenethylamines represented by the formula

    wherein R is H, halo or CF3 and acid addition salts thereof. The compounds are useful as appetite depressants.

    Abstract translation: 由式-CH2-CH-NH-CH2-CH2-O-CH = CH2 | CH3表示的新型N-乙烯氧基乙基-α-甲基-β-苯乙胺，其中R为H，卤素或CF 3及其酸加成盐。 该化合物可用作食欲抑制剂。

    N-substituted -alpha-methyl-3,4-(methylenedioxy) phenethylamines
    4.
    发明授权
    N-substituted -alpha-methyl-3,4-(methylenedioxy) phenethylamines 失效
    N-取代的 - 甲基-3,4-（甲基二氧基）苯乙烯

    公开(公告)号：US3689504A

    公开(公告)日：1972-09-05

    申请号：US3689504D

    申请日：1970-12-24

    Applicant: ABBOTT LAB

    Inventor： HORROM BRUCE WAYNE

    IPC: C07D317/58 ,  C07D13/10

    CPC classification number: C07D317/58

    Abstract: N-substituted- Alpha -methyl-3,4-(methylenedioxy)phenethylamines of the formula:

    WHEREIN R is cyclopropyl or cyclopropylmethyl. The compounds are useful as appetite depressants.

    Abstract translation: 具有下式的N-取代-α-甲基-3,4-（亚甲二氧基）苯乙胺：

    2-propargylamino-5-phenyl-2-oxazolin-4-one and derivatives
    5.
    发明授权
    2-propargylamino-5-phenyl-2-oxazolin-4-one and derivatives 失效
    2-丙酰氨基-5-苯基-2-氧杂环戊烯-4-酮和衍生物

    公开(公告)号：US3578672A

    公开(公告)日：1971-05-11

    申请号：US3578672D

    申请日：1969-11-03

    Applicant: ABBOTT LAB

    Inventor： LEE CHEUK MAN ,  HORROM BRUCE WAYNE

    IPC: C07D263/48 ,  C07D85/40

    CPC classification number: C07D263/48

    Abstract: 2-PROPARGYLAMINO-5-PHENYL-2-OXAZOLINE-4-ONE AND DERIVATIVES THEREOF WERE FOUND TO BE EFFECTIVE ANTI-DEPRESSANTS WHEN ADMINISTERED IN ORAL DOSAGES OF 0.5-20 MG./KG. TO WARM-BLOODED ANIMALS. THE NEW COMPOUNDS ARE PREPARED BY CONDENSING 2-AMINO-5-PHENYL-2-OXAZOLIN-4-ONE WITH PROPARGYLAMINE OR THE CORRESPONDING N- AND/OR 1-MONOOR DISUBSTITUTED ALKYL DERIVATIVES THEREOF IN THE PRESENCE OR ABSENCE OF AN INERT REACTION MEDIUM.

    N-3 4-dihalo phenyl piperazines
    7.
    发明授权
    N-3 4-dihalo phenyl piperazines 失效
    N-3 4-DIHALO PHENYL PIPERAZINES

    公开(公告)号：US3637705A

    公开(公告)日：1972-01-25

    申请号：US3637705D

    申请日：1968-10-01

    Applicant: ABBOTT LAB

    Inventor： HORROM BRUCE WAYNE ,  WRIGHT HOWARD BERNARD

    IPC: C07D295/073 ,  C07D51/70

    CPC classification number: C07D295/073 ,  Y10S514/91

    Abstract: IT HAS BEEN FOUND THAT CERTAIN SPECIFICALLY HALOGEN SUBSTITUTED N-PHENYLPIPERAZINES AND N-PHENYL-N''-TETRAHYDROPYRANYLPIPERAZINES HAVE UNUSUALLY STRONG ANOREXIGENIC PROPERITIES. THE SPECIFIC SUBSTITUENTS MUST BE IN THE 3- AND 4-POSITIONS OF THE PHENYL RING TO PRODUCE THESE OUTSTANDING PHARMACOLOGICAL RESULTS.

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