公开(公告)号：WO2008060767A2

公开(公告)日：2008-05-22

申请号：PCT/US2007080133

申请日：2007-10-02

Applicant: ABBOTT LAB ,  ALTENBACH ROBERT J ,  LIU HUAQING ,  DRIZIN IRENE ,  COWART MARLON D ,  WISHART NEIL ,  BABINSKI DAVID J ,  GREGG ROBERT J ,  ESBENSHADE TIMOTHY A ,  HSIEH GIN C ,  BRIONI JORGE D ,  HONORE MARIE P ,  BLACK LAWRENCE A ,  ZHAO CHEN ,  WAKEFIELD BRIAN D

Inventor： ALTENBACH ROBERT J ,  LIU HUAQING ,  DRIZIN IRENE ,  COWART MARLON D ,  WISHART NEIL ,  BABINSKI DAVID J ,  GREGG ROBERT J ,  ESBENSHADE TIMOTHY A ,  HSIEH GIN C ,  BRIONI JORGE D ,  HONORE MARIE P ,  BLACK LAWRENCE A ,  ZHAO CHEN ,  WAKEFIELD BRIAN D ,  HANCOCK ARTHUR A

IPC: C07D491/04 ,  C07D493/04 ,  C07H17/04

CPC classification number: C07H17/04 ,  C07D239/70 ,  C07D403/12 ,  C07D453/04 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  C07D491/04 ,  C07D495/04 ,  C07D519/00

Abstract: Macrocyclic benzofused pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions and disorders using such compounds and compositions are described herein.

Abstract translation: 本文描述了大环苯并稠合的嘧啶化合物，包含此类化合物的组合物，制备所述化合物的方法以及使用此类化合物和组合物治疗和预防疾病，病症和障碍进展的方法。

公开(公告)号：WO0241894A3

公开(公告)日：2002-10-17

申请号：PCT/US0143139

申请日：2001-11-21

Applicant: ABBOTT LAB

Inventor： BRIONI JORGE D ,  KOLASA TEODOZYJ ,  HSIEH GIN C ,  DONNELLY-ROBERTS DIANE L

IPC: A61K45/00 ,  A61K31/495 ,  A61K31/496 ,  A61K45/06 ,  A61P15/00 ,  A61P15/02 ,  A61P15/10

CPC classification number: A61K45/06 ,  A61K31/495 ,  A61K31/496 ,  A61K2300/00

Abstract: The present invention relates to the use of selective dopamine D4 receptor agonists and to compositions containing selective dopamine D4 receptor agonists for the treatment of sexual dysfunction.

Abstract translation: 本发明涉及选择性多巴胺D4受体激动剂和含有选择性多巴胺D4受体激动剂用于治疗性功能障碍的组合物的用途。

公开(公告)号：WO2010129242A2

公开(公告)日：2010-11-11

申请号：PCT/US2010032488

申请日：2010-04-27

Applicant: ABBOTT LAB ,  COWART MARLON D ,  HSIEH GIN C ,  BRIONI JORGE D ,  SULLIVAN JAMES P

Inventor： COWART MARLON D ,  HSIEH GIN C ,  BRIONI JORGE D ,  SULLIVAN JAMES P

IPC: A61K31/395 ,  A61K31/41 ,  A61P29/00

CPC classification number: A61K31/551 ,  A61K31/395 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/41 ,  A61K31/425 ,  A61K31/428 ,  A61K31/4375 ,  A61K31/445 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/517 ,  A61K31/55

Abstract: This invention discloses a method of treatment of osteoarthritis pain by administration of a histamine H3 receptor antagonist, described herein, a salt thereof, or a composition comprising such compound or salt.

Abstract translation: 本发明公开了通过施用本文所述的组胺H3受体拮抗剂，其盐或包含所述化合物或盐的组合物来治疗骨关节炎疼痛的方法。

公开(公告)号：WO2008060766A3

公开(公告)日：2009-02-19

申请号：PCT/US2007080132

申请日：2007-10-02

Applicant: ABBOTT LAB ,  COWART MARLON D ,  ALTENBACH ROBERT J ,  LIU HUAQING ,  DRIZIN IRENE ,  WISHART NEIL ,  BABINSKI DAVID J ,  GREGG ROBERT J ,  ESBENSHADE TIMOTHY A ,  HSIEH GIN C ,  BRIONI JORGE D ,  HONORE MARIE P ,  BLACK LAWRENCE A ,  ZHAO CHEN ,  WAKEFIELD BRIAN D

Inventor： COWART MARLON D ,  ALTENBACH ROBERT J ,  LIU HUAQING ,  DRIZIN IRENE ,  WISHART NEIL ,  BABINSKI DAVID J ,  GREGG ROBERT J ,  ESBENSHADE TIMOTHY A ,  HSIEH GIN C ,  BRIONI JORGE D ,  HONORE MARIE P ,  BLACK LAWRENCE A ,  ZHAO CHEN ,  WAKEFIELD BRIAN D ,  HANCOCK ARTHUR A

IPC: A61K31/417 ,  A61K31/496 ,  A61K31/506 ,  A61K45/06 ,  A61P29/00

CPC classification number: A61K31/506 ,  A61K31/417 ,  A61K31/496 ,  A61K45/06

Abstract: This invention discloses histamine H4 receptor ligands for use in a method of treating pain

Abstract translation: 本发明公开了用于治疗疼痛的方法中的组胺H 4受体配体

公开(公告)号：AU2002226895B2

公开(公告)日：2006-10-12

申请号：AU2002226895

申请日：2001-11-21

Applicant: ABBOTT LAB

Inventor： KOLASA TEODOZYJ ,  HSIEH GIN C ,  BRIONI JORGE D ,  DONNELLY-ROBERTS DIANE L

IPC: A61K31/496 ,  A61K45/00 ,  A61K31/495 ,  A61K45/06 ,  A61P15/00 ,  A61P15/02 ,  A61P15/10

Abstract: The present invention relates to the use of selective dopamine D4 receptor agonists and to compositions containing selective dopamine D4 receptor agonists for the treatment of sexual dysfunction.

公开(公告)号：BG107810A

公开(公告)日：2004-02-27

申请号：BG10781003

申请日：2003-05-13

Applicant: ABBOTT LAB

Inventor： BRIONI JORGE D ,  KOLASA TEODOZYJ ,  HSIEH GIN C ,  DONNELLY-ROBERTS DIANE L

IPC: A61K45/00 ,  A61K31/495 ,  A61K31/496 ,  A61K45/06 ,  A61P15/00 ,  A61P15/02 ,  A61P15/10

Abstract: The present invention relates to the use of selective dopamine D4 receptor agonists and to compositions containing selective dopamine D4 receptor agonists for the treatment of sexual dysfunction. 31 claims

公开(公告)号：PE05572002A1

公开(公告)日：2002-06-25

申请号：PE0011642001

申请日：2001-11-21

Applicant: ABBOTT LAB

Inventor： BRIONI JORGE D ,  KOLASA TEODOZYJ ,  HSIEH GIN C ,  DONNELLY-ROBERTS DIANA L

IPC: A61K45/00 ,  A61K31/495 ,  A61K31/496 ,  A61K45/06 ,  A61P15/00 ,  A61P15/02 ,  A61P15/10

CPC classification number: A61K45/06 ,  A61K31/495 ,  A61K31/496 ,  A61K2300/00

Abstract: SE REFIERE AL USO DE UN AGONISTA DEL RECEPTOR DE DOPAMINA D4 CON LA SALVEDAD QUE DICHO AGONISTA NO SEA 5,6,6a-7-TETRAHIDRO-6-METIL-4H-DIBENZO[de,g]QUINOLINA-10,11-DIOL. EL AGONISTA DEL RECEPTOR DE DOPAMINA D4 SE SELECCIONA DE N-{[4-(2-CIANOFENIL)-1-PIPERAZINIL]METIL}-3-METILBENZAMIDA, 5-FLUORO-2-{[4-(2-PIRIDINIL)-1-PIPERAZINIL]METIL}-1H-INDOL DONDE DICHO AGONISTA DE DOPAMINA ES MAS SELECTIVO POR EL RECEPTOR D4 QUE POR EL RECEPTOR D2. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA UTIL PARA EL TRATAMIENTO DE UNA DISFUNCION SEXUAL

公开(公告)号：NZ525086A

公开(公告)日：2006-07-28

申请号：NZ52508601

申请日：2001-11-21

Applicant: ABBOTT LAB

Inventor： BRIONI JORGE D ,  KOLASA TEODOZYJ ,  HSIEH GIN C ,  DONNELLY-ROBERTS DIANE L

IPC: A61K45/00 ,  A61K31/495 ,  A61K31/496 ,  A61K45/06 ,  A61P15/00 ,  A61P15/02 ,  A61P15/10

Abstract: Disclosed herein is a method of treating human sexual dysfunction and male erectile dysfunction in a mammal that comprises the administration of a therapeutically effective amount of a selective dopamine D4 receptor agonist or a pharmaceutically acceptable salt thereof.

公开(公告)号：CZ20031458A3

公开(公告)日：2004-02-18

申请号：CZ20031458

申请日：2001-11-21

Applicant: ABBOTT LAB

Inventor： BRIONI JORGE D ,  KOLASA TEODOZYJ ,  HSIEH GIN C ,  DONNELLY-ROBERTS DIANE L

IPC: A61K45/00 ,  A61K31/495 ,  A61K31/496 ,  A61K45/06 ,  A61P15/00 ,  A61P15/02 ,  A61P15/10

Abstract: The present invention relates to the use of selective dopamine D4 receptor agonists and to compositions containing selective dopamine D4 receptor agonists for the treatment of sexual dysfunction.

公开(公告)号：AU2689502A

公开(公告)日：2002-06-03

申请号：AU2689502

申请日：2001-11-21

Applicant: ABBOTT LAB

Inventor： BRIONI JORGE D ,  KOLASA TEODOZYJ ,  HSIEH GIN C ,  DONNELLY-ROBERTS DIANE L

IPC: A61K45/00 ,  A61K31/495 ,  A61K31/496 ,  A61K45/06 ,  A61P15/00 ,  A61P15/02 ,  A61P15/10

Abstract: The present invention relates to the use of selective dopamine D4 receptor agonists and to compositions containing selective dopamine D4 receptor agonists for the treatment of sexual dysfunction.