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公开(公告)号：WO0109096A3
公开(公告)日：2001-08-16
申请号：PCT/US0021054
申请日：2000-08-02
Applicant: ABBOTT LAB
Inventor： ALTENBACH ROBERT J , BAI HAO , BRIONI JORGE D , CARROLL WILLIAM A , GOPALAKRISHNAN MURALI , GREGG ROBERT J , HOLLADAY MARK W , HUANG PEGGY P , KINCAID JOHN F , KORT MICHAEL E , KYM PHILIP R , LYNCH JOHN K , PEREZ-MEDRANO ARTURO , ZHANG HENRY Q
IPC: C07D249/18 , A61K31/166 , A61K31/17 , A61K31/417 , A61K31/4192 , A61K31/44 , A61K31/4406 , A61K31/47 , A61P1/00 , A61P9/00 , A61P9/10 , A61P11/06 , A61P13/02 , A61P13/08 , A61P13/10 , A61P15/00 , A61P15/10 , A61P17/14 , A61P25/00 , A61P25/02 , A61P25/06 , A61P25/08 , C07C233/78 , C07C233/83 , C07C271/22 , C07C275/28 , C07C275/30 , C07C275/54 , C07C279/22 , C07C279/28 , C07C279/36 , C07C335/16 , C07C335/18 , C07C335/26 , C07D209/08 , C07D213/74 , C07D213/75 , C07D215/38 , C07D233/02 , C07D233/42 , C07D235/06 , C07D239/42 , C07D401/04 , C07D401/12 , C07D405/12 , C07D407/12 , A61K31/155 , C07C279/30
CPC classification number: C07D213/74 , A61K31/17 , C07C233/78 , C07C233/83 , C07C271/22 , C07C275/28 , C07C275/30 , C07C279/28 , C07C279/36 , C07C335/16 , C07C335/18 , C07D209/08 , C07D215/38 , C07D233/42 , C07D235/06 , C07D239/42 , C07D401/04 , C07D401/12 , C07D405/12
Abstract: Compounds of formula (I), are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
Abstract translation: 式（I）化合物可用于治疗钾通道开放剂所预防或改善的疾病。 还公开了钾通道开放组合物和在哺乳动物中打开钾通道的方法。
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公开(公告)号：WO2008060767A2
公开(公告)日：2008-05-22
申请号：PCT/US2007080133
申请日：2007-10-02
Applicant: ABBOTT LAB , ALTENBACH ROBERT J , LIU HUAQING , DRIZIN IRENE , COWART MARLON D , WISHART NEIL , BABINSKI DAVID J , GREGG ROBERT J , ESBENSHADE TIMOTHY A , HSIEH GIN C , BRIONI JORGE D , HONORE MARIE P , BLACK LAWRENCE A , ZHAO CHEN , WAKEFIELD BRIAN D
Inventor： ALTENBACH ROBERT J , LIU HUAQING , DRIZIN IRENE , COWART MARLON D , WISHART NEIL , BABINSKI DAVID J , GREGG ROBERT J , ESBENSHADE TIMOTHY A , HSIEH GIN C , BRIONI JORGE D , HONORE MARIE P , BLACK LAWRENCE A , ZHAO CHEN , WAKEFIELD BRIAN D , HANCOCK ARTHUR A
IPC: C07D491/04 , C07D493/04 , C07H17/04
CPC classification number: C07H17/04 , C07D239/70 , C07D403/12 , C07D453/04 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/04 , C07D495/04 , C07D519/00
Abstract: Macrocyclic benzofused pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions and disorders using such compounds and compositions are described herein.
Abstract translation: 本文描述了大环苯并稠合的嘧啶化合物，包含此类化合物的组合物，制备所述化合物的方法以及使用此类化合物和组合物治疗和预防疾病，病症和障碍进展的方法。
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公开(公告)号：WO2010129242A2
公开(公告)日：2010-11-11
申请号：PCT/US2010032488
申请日：2010-04-27
Applicant: ABBOTT LAB , COWART MARLON D , HSIEH GIN C , BRIONI JORGE D , SULLIVAN JAMES P
Inventor： COWART MARLON D , HSIEH GIN C , BRIONI JORGE D , SULLIVAN JAMES P
IPC: A61K31/395 , A61K31/41 , A61P29/00
CPC classification number: A61K31/551 , A61K31/395 , A61K31/40 , A61K31/4025 , A61K31/41 , A61K31/425 , A61K31/428 , A61K31/4375 , A61K31/445 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/517 , A61K31/55
Abstract: This invention discloses a method of treatment of osteoarthritis pain by administration of a histamine H3 receptor antagonist, described herein, a salt thereof, or a composition comprising such compound or salt.
Abstract translation: 本发明公开了通过施用本文所述的组胺H3受体拮抗剂，其盐或包含所述化合物或盐的组合物来治疗骨关节炎疼痛的方法。
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公开(公告)号：WO2008060766A3
公开(公告)日：2009-02-19
申请号：PCT/US2007080132
申请日：2007-10-02
Applicant: ABBOTT LAB , COWART MARLON D , ALTENBACH ROBERT J , LIU HUAQING , DRIZIN IRENE , WISHART NEIL , BABINSKI DAVID J , GREGG ROBERT J , ESBENSHADE TIMOTHY A , HSIEH GIN C , BRIONI JORGE D , HONORE MARIE P , BLACK LAWRENCE A , ZHAO CHEN , WAKEFIELD BRIAN D
Inventor： COWART MARLON D , ALTENBACH ROBERT J , LIU HUAQING , DRIZIN IRENE , WISHART NEIL , BABINSKI DAVID J , GREGG ROBERT J , ESBENSHADE TIMOTHY A , HSIEH GIN C , BRIONI JORGE D , HONORE MARIE P , BLACK LAWRENCE A , ZHAO CHEN , WAKEFIELD BRIAN D , HANCOCK ARTHUR A
IPC: A61K31/417 , A61K31/496 , A61K31/506 , A61K45/06 , A61P29/00
CPC classification number: A61K31/506 , A61K31/417 , A61K31/496 , A61K45/06
Abstract: This invention discloses histamine H4 receptor ligands for use in a method of treating pain
Abstract translation: 本发明公开了用于治疗疼痛的方法中的组胺H 4受体配体
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公开(公告)号：WO02062762A3
公开(公告)日：2003-07-31
申请号：PCT/US0205252
申请日：2002-01-17
Applicant: ABBOTT LAB
Inventor： ALTENBACH ROBERT J , BAI HAO , BRIONI JORGE D , CARROLL WILLIAM A , GOPALAKRISHNAN MURALI , GREGG ROBERT J , HOLLADAY MARK W , HUANG PEGGY P , KINCAID JOHN F , KORT MICHAEL E , KYM PHILIP R , LYNCH JOHN K , PEREZ-MEDRANO ARTURO , ZHANG HENRY Q
IPC: A61K31/17 , A61K31/275 , A61K31/4164 , A61K31/4406 , A61K31/455 , A61K31/47 , A61K31/505 , A61P1/00 , A61P9/00 , A61P9/04 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/08 , A61P13/10 , A61P15/00 , A61P15/06 , A61P15/10 , A61P17/00 , A61P17/14 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/28 , A61P43/00 , C07C233/36 , C07C233/78 , C07C233/83 , C07C255/61 , C07C271/22 , C07C275/28 , C07C275/30 , C07C279/28 , C07C279/36 , C07C335/16 , C07C335/18 , C07C335/20 , C07D209/08 , C07D209/30 , C07D213/40 , C07D213/74 , C07D213/75 , C07D213/82 , C07D215/38 , C07D233/42 , C07D233/84 , C07D235/06 , C07D239/42 , C07D333/20 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/12
CPC classification number: C07D213/40 , A61K31/17 , A61K31/275 , A61K31/4406 , C07C233/78 , C07C233/83 , C07C271/22 , C07C275/28 , C07C275/30 , C07C279/28 , C07C279/36 , C07C335/16 , C07C335/18 , C07D209/08 , C07D213/74 , C07D213/75 , C07D213/82 , C07D215/38 , C07D233/42 , C07D233/84 , C07D235/06 , C07D239/42 , C07D333/20 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Compounds of formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
Abstract translation: 式（I）化合物可用于治疗用钾通道开放剂预防或改善的疾病。 还公开了钾通道开放组合物和在哺乳动物中开放钾通道的方法。
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Patent Agency Ranking6.发明申请SELECTIVE DOPAMINE D4 RECEPTOR AGONISTS FOR TREATING SEXUAL DYSFUNCTION 审中-公开选择性DOPAMINE D4受体激动剂治疗性功能障碍
公开(公告)号：WO0241894A3
公开(公告)日：2002-10-17
申请号：PCT/US0143139
申请日：2001-11-21
Applicant: ABBOTT LAB
Inventor： BRIONI JORGE D , KOLASA TEODOZYJ , HSIEH GIN C , DONNELLY-ROBERTS DIANE L
IPC: A61K45/00 , A61K31/495 , A61K31/496 , A61K45/06 , A61P15/00 , A61P15/02 , A61P15/10
CPC classification number: A61K45/06 , A61K31/495 , A61K31/496 , A61K2300/00
Abstract: The present invention relates to the use of selective dopamine D4 receptor agonists and to compositions containing selective dopamine D4 receptor agonists for the treatment of sexual dysfunction.
Abstract translation: 本发明涉及选择性多巴胺D4受体激动剂和含有选择性多巴胺D4受体激动剂用于治疗性功能障碍的组合物的用途。
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公开(公告)号：MY139385A
公开(公告)日：2009-09-30
申请号：MYPI20020834
申请日：2002-03-08
Applicant: ABBOTT LAB
Inventor： COWART MARLON D , BHATIA PRAMILA A , DAANEN JEROME F , STEWART ANDREW O , PATEL MEENA V , KOLASA TEODOZYJ , BRIONI JORGE D , ROHDE JEFFREY J
IPC: C07D235/06 , C07D235/10 , C07D235/14 , C07D401/12 , C07D401/14 , C07D417/12
Abstract: THE PRESENT INVENTION RELATES TO THE USE OF COMPOUNDS OF FORMULA (1) F1FOR THE TREATMENT OF SEXUAL DYSFUNCTION AND TO COMPOSITIONS CONTAINING COMPOUNDS OF FORMULA (1) FOR THE TREATMENT OF SEXUAL DYSFUNCTION.
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公开(公告)号：NO326686B1
公开(公告)日：2009-01-26
申请号：NO20033959
申请日：2003-09-08
Applicant: ABBOTT LAB
Inventor： COWART MARLON D , KOLASA TEODOZYJ , ROHDE JEFFREY J , STEWART ANDREW O , BHATIA PRAMILA A , DAANEN JEROME F , BRIONI JORGE D , PATEL MEENA V
IPC: C07D235/14 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K45/00 , A61P9/10 , A61P15/08 , A61P15/10 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P29/00 , C07D235/10 , C07D401/06 , C07D401/12 , C07D401/14 , C07D417/12
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公开(公告)号：DE60036476D1
公开(公告)日：2007-10-31
申请号：DE60036476
申请日：2000-08-02
Applicant: ABBOTT LAB
Inventor： ALTENBACH ROBERT J , BAI HAO , BRIONI JORGE D , CARROLL WILLIAM A , GOPALAKRISHNAN MURALI , GREGG ROBERT J , HOLLADAY MARK W , HUANG PEGGY P , KINCAID JOHN F , KORT MICHAEL E , KYM PHILIP R , LYNCH JOHN K , PEREZ-MEDRANO ARTURO , ZHANG HENRY Q
IPC: C07D213/74 , C07D249/18 , A61K31/166 , A61K31/17 , A61K31/417 , A61K31/4192 , A61K31/44 , A61K31/4406 , A61K31/47 , A61P1/00 , A61P9/00 , A61P9/10 , A61P11/06 , A61P13/02 , A61P13/08 , A61P13/10 , A61P15/00 , A61P15/10 , A61P17/14 , A61P25/00 , A61P25/02 , A61P25/06 , A61P25/08 , C07C233/78 , C07C233/83 , C07C271/22 , C07C275/28 , C07C275/30 , C07C275/54 , C07C279/22 , C07C279/28 , C07C279/30 , C07C279/36 , C07C335/16 , C07C335/18 , C07C335/26 , C07D209/08 , C07D213/75 , C07D215/38 , C07D233/02 , C07D233/42 , C07D235/06 , C07D239/42 , C07D401/04 , C07D401/12 , C07D405/12 , C07D407/12
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公开(公告)号：AU2002226895B2
公开(公告)日：2006-10-12
申请号：AU2002226895
申请日：2001-11-21
Applicant: ABBOTT LAB
Inventor： KOLASA TEODOZYJ , HSIEH GIN C , BRIONI JORGE D , DONNELLY-ROBERTS DIANE L
IPC: A61K31/496 , A61K45/00 , A61K31/495 , A61K45/06 , A61P15/00 , A61P15/02 , A61P15/10
Abstract: The present invention relates to the use of selective dopamine D4 receptor agonists and to compositions containing selective dopamine D4 receptor agonists for the treatment of sexual dysfunction.
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