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公开(公告)号：WO9621670A3
公开(公告)日：1996-09-12
申请号：PCT/US9600225
申请日：1996-01-03
Applicant: ABBOTT LAB
Inventor： ALDER LISA A , BURRES NEAL S , HOCHLOWSKI JILL E , JACKSON MARIANNA , MCALPINE JAMES B , KLEIN LARRY L , LARTEY PAUL A , YEUNG CLINTON
IPC: C12P17/06 , A01N43/16 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/04 , A61P31/10 , C07H15/10 , C07H17/04 , C12R1/645
Abstract: Novel antifungal agents having formula (I), wherein R is hydrogen or -C(O)-R1 wherein R1 is alkenyl, C2-C12-alkyl, aryl, arylalkenyl, arylalkyl, aryl-aryl-, arylalkoxy-aryl-, aryloxyl-aryl-, aryl-aryl-aryl- or arylalkoxy-aryl-aryl-, or pharmaceutically acceptable salts, esters or prodrugs thereof, as well as (i) pharmaceutical compositions comprising such compounds, (ii) methods of treatment using such compounds, and (iv) methods and fungal cultures useful in making the same.
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公开(公告)号：ES2186900T3
公开(公告)日：2003-05-16
申请号：ES97931411
申请日：1997-06-24
Applicant: ABBOTT LAB
Inventor： HOCHLOWSKI JILL E , JACKSON MARIANNA , MCALPINE JAMES B , RASMUSSEN RONALD R
Abstract: Antimicrobial compounds having the formula wherein R1 and R2 are independently selected from the group consisting of hydrogen and C1-to-C4 alkanoyl; R3 and R4 are selected from the group consisting of (a) R3 is hydrogen and R4 is hydroxy, (b) R3 is hydroxy and R4 is hydrogen, (c) R3 and R4 taken together are =O; or selected from the group consisting of hydrogen and hydroxy; and R5 and R6 are independently selected from the group consisting of hydrogen, bromine and chlorine, with the proviso that at least one of R5 and R6 must be bromine. Also disclosed are pharmaceutical compositions comprising such compounds, methods of treating bacterial infection by the administration thereof and a process for preparing said compounds.
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公开(公告)号：AU706072B2
公开(公告)日：1999-06-10
申请号：AU4748496
申请日：1996-01-03
Applicant: ABBOTT LAB
Inventor： ALDER LISA A , BURRES NEAL S , HOCHLOWSKI JILL E , JACKSON MARIANNA , MCALPINE JAMES B , KLEIN LARRY L , LARTEY PAUL A , YEUNG CLINTON
IPC: C12P17/06 , A01N43/16 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/04 , A61P31/10 , C07H15/10 , C07H17/04 , C12R1/645
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公开(公告)号：CZ2899A3
公开(公告)日：1999-03-17
申请号：CZ2899
申请日：1997-06-24
Applicant: ABBOTT LAB
Inventor： HOCHLOWSKI JILL E , JACKSON MARIANNA , MCALPINE JAMES B , RASMUSSEN RONALD R
Abstract: Antimicrobial compounds having the formula wherein R1 and R2 are independently selected from the group consisting of hydrogen and C1-to-C4 alkanoyl; R3 and R4 are selected from the group consisting of (a) R3 is hydrogen and R4 is hydroxy, (b) R3 is hydroxy and R4 is hydrogen, (c) R3 and R4 taken together are =O; or selected from the group consisting of hydrogen and hydroxy; and R5 and R6 are independently selected from the group consisting of hydrogen, bromine and chlorine, with the proviso that at least one of R5 and R6 must be bromine. Also disclosed are pharmaceutical compositions comprising such compounds, methods of treating bacterial infection by the administration thereof and a process for preparing said compounds.
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公开(公告)号：GR900100078A
公开(公告)日：1991-06-28
申请号：GR90100078
申请日：1990-02-07
Applicant: ABBOTT LAB
Inventor： BRILL M GREGORY , JACKSON MARIANNA , KARWOWSKI P JAMES , MCALPINE B JAMES , THERIAULT J ROBERT
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Patent Agency Ranking
公开(公告)号：PT93070A
公开(公告)日：1990-08-31
申请号：PT9307090
申请日：1990-02-06
Applicant: ABBOTT LAB
Inventor： MCALPINE JAMES B , THERIAULT ROBERT J , KARWOWSKI JAMES P , JACKSON MARIANNA , BRILL GREGORY M
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公开(公告)号：CZ294843B6
公开(公告)日：2005-03-16
申请号：CZ2899
申请日：1997-06-24
Applicant: ABBOTT LAB
Inventor： HOCHLOWSKI JILL E , JACKSON MARIANNA , MCALPINE JAMES B , RASMUSSEN RONALD R
IPC: C12P17/16 , A61K31/7048 , A61P31/04 , C07H17/08 , C12R1/01
Abstract: In the present invention, there are described bromotiacumicin compounds of the general formula I, in which Re1 and Re2 are independently selected from the group consisting of hydrogen and alkanoyl containing 1 to 4 carbon atoms; Re3 and Re4 are selected from the group consisting of (a) Re3 represents hydrogen and Re4 denotes hydroxy, (b) Re3 represents hydroxy and Re4 denotes hydrogen, (c) Re3 and Re4 taken together are =O; or selected from the group consisting of hydrogen and hydroxy; and Re5 and Re6 are independently selected from the group consisting of hydrogen, bromine and chlorine, with the proviso that at least one of Re5 and Re6 must be bromine. Also described are pharmaceutical compositions comprising such compounds, and use of these compounds for the preparation of a medicament intended for treating bacterial infection. Process for preparing the above-described compounds comprises culturing a microorganism belonging to the species dactylosporangium aurantiacum subsp. hamdenensis in a bromide enriched nutrient medium.
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公开(公告)号：DE69615657T2
公开(公告)日：2002-08-08
申请号：DE69615657
申请日：1996-01-03
Applicant: ABBOTT LAB
Inventor： ALDER A , BURRES S , HOCHLOWSKI E , JACKSON MARIANNA , MCALPINE B , KLEIN L , LARTEY A , YEUNG CLINTON
IPC: C12P17/06 , A01N43/16 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/04 , A61P31/10 , C07H15/10 , C07H17/04 , C12R1/645
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公开(公告)号：PT802920E
公开(公告)日：2002-03-28
申请号：PT96903378
申请日：1996-01-03
Applicant: ABBOTT LAB
Inventor： KLEIN LARRY L , MCALPINE JAMES B , JACKSON MARIANNA , LARTEY PAUL A , HOCHLOWSKI JILL E , ALDER LISA A , BURRES NEAL S , YEUNG CLINTON
IPC: C12P17/06 , A01N43/16 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/04 , A61P31/10 , C07H15/10 , C07H17/04 , C12R1/645
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公开(公告)号：AT206431T
公开(公告)日：2001-10-15
申请号：AT96903378
申请日：1996-01-03
Applicant: ABBOTT LAB
Inventor： ALDER LISA A , BURRES NEAL S , HOCHLOWSKI JILL E , JACKSON MARIANNA , MCALPINE JAMES B , KLEIN LARRY L , LARTEY PAUL A , YEUNG CLINTON
IPC: C12P17/06 , A01N43/16 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/04 , A61P31/10 , C07H15/10 , C07H17/04 , C12R1/645
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