公开(公告)号：WO0020441A3

公开(公告)日：2000-11-23

申请号：PCT/US9922844

申请日：1999-10-01

Applicant: ABBOTT LAB

Inventor： WANG WEI-BO ,  LI QUN ,  HASVOLD LISA A ,  CHEN HUI-JU ,  LI LEPING ,  LARTEY PAUL A ,  CLAIBORNE AKIYO ,  STEINER BETH A ,  BENNANI YOUSSEF ,  DICKMAN DANIEL ,  DING HONG

IPC: C07C67/343 ,  C07D295/155 ,  C07K7/56 ,  A61K38/12 ,  A61P33/08

CPC classification number: C07D295/155 ,  C07C67/343 ,  C07K7/56 ,  C07C69/94

Abstract: The invention relates to a novel cyclic hexapeptide having antifungal and antipneumocystic activity as well as pharmaceutical compositions comprising, methods of treating using, and a process for preparing the claimed compounds.

Abstract translation: 本发明涉及具有抗真菌和抗肺囊虫活性的新型环状六肽以及药物组合物，其包含使用方法和制备所要求保护的化合物的方法。

公开(公告)号：WO9621670A3

公开(公告)日：1996-09-12

申请号：PCT/US9600225

申请日：1996-01-03

Applicant: ABBOTT LAB

Inventor： ALDER LISA A ,  BURRES NEAL S ,  HOCHLOWSKI JILL E ,  JACKSON MARIANNA ,  MCALPINE JAMES B ,  KLEIN LARRY L ,  LARTEY PAUL A ,  YEUNG CLINTON

IPC: C12P17/06 ,  A01N43/16 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  A61P31/10 ,  C07H15/10 ,  C07H17/04 ,  C12R1/645

CPC classification number: C07H15/10 ,  A01N43/16

Abstract: Novel antifungal agents having formula (I), wherein R is hydrogen or -C(O)-R1 wherein R1 is alkenyl, C2-C12-alkyl, aryl, arylalkenyl, arylalkyl, aryl-aryl-, arylalkoxy-aryl-, aryloxyl-aryl-, aryl-aryl-aryl- or arylalkoxy-aryl-aryl-, or pharmaceutically acceptable salts, esters or prodrugs thereof, as well as (i) pharmaceutical compositions comprising such compounds, (ii) methods of treatment using such compounds, and (iv) methods and fungal cultures useful in making the same.

公开(公告)号：EP0707482A4

公开(公告)日：1997-03-19

申请号：EP94923344

申请日：1994-07-06

Applicant: ABBOTT LAB

Inventor： EDWARDS CARLA ,  LARTEY PAUL A

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

CPC classification number: C07H17/08

公开(公告)号：AU6408499A

公开(公告)日：2000-04-26

申请号：AU6408499

申请日：1999-10-01

Applicant: ABBOTT LAB

Inventor： WANG WEI-BO ,  LI QUN ,  HASVOLD LISA A ,  CHEN HUI-JU ,  LI LEPING ,  LARTEY PAUL A ,  CLAIBORNE AKIYO ,  STEINER BETH A ,  BENNANI YOUSSEF ,  DICKMAN DANIEL ,  DING HONG

IPC: C07C67/343 ,  C07D295/155 ,  C07K7/56 ,  C07K7/00

公开(公告)号：GR3030692T3

公开(公告)日：1999-11-30

申请号：GR990401774

申请日：1999-07-05

Applicant: ABBOTT LAB

Inventor： EDWARDS CARLA ,  LARTEY PAUL A

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

Abstract: Antibacterial compounds having the formula and pharmaceutically acceptable salts thereof, wherein Y is selected from isting of -C(O)-, -C(S)-, -CH2-, -CH2CH2- and -C(CH3)2-; also disclosed are processes and intermediates useful in the preparation of the above compounds, as well as compositions containing the same and methods for their use.

公开(公告)号：ES2133567T3

公开(公告)日：1999-09-16

申请号：ES94923344

申请日：1994-07-06

Applicant: ABBOTT LAB

Inventor： EDWARDS CARLA ,  LARTEY PAUL A

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

Abstract: Antibacterial compounds having the formula and pharmaceutically acceptable salts thereof, wherein Y is selected from isting of -C(O)-, -C(S)-, -CH2-, -CH2CH2- and -C(CH3)2-; also disclosed are processes and intermediates useful in the preparation of the above compounds, as well as compositions containing the same and methods for their use.

公开(公告)号：DE69317877T2

公开(公告)日：1998-10-29

申请号：DE69317877

申请日：1993-01-19

Applicant: ABBOTT LAB

Inventor： LARTEY PAUL A ,  NELLANS HUGH N ,  KLEIN LARRY L ,  FAGHIH RAMIN

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  A61P1/08 ,  A61P1/10 ,  A61P31/04 ,  C07D233/22 ,  C07H17/08

Abstract: 4''-Deoxy derivatives of erythromycin having the Formula (I) (I) and pharmaceutically acceptable salts thereof, which are enhancers of gastric motility but have minimal antibacterial activity, as well as pharmaceutical compositions containing the same and methods for their use and preparation.

公开(公告)号：AT151772T

公开(公告)日：1997-05-15

申请号：AT89109890

申请日：1989-06-01

Applicant: ABBOTT LAB

Inventor： PARIZA RICHARD J ,  MARING CLARENCE J ,  LARTEY PAUL A ,  KLEIN LARRY L

IPC: A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61K31/7052 ,  A61P31/00 ,  A61P31/04 ,  C07H17/08 ,  C07H19/04

Abstract: Semisynthetic antibiotics with improved therapeutic properties are disclosed. In particular, 9-R-azacyclic derivatives of erythromycin, its derivatives, and their salts and esters show superior antimicrobial activity compared to other macrolide compounds.

公开(公告)号：AU609307B2

公开(公告)日：1991-04-26

申请号：AU3610289

申请日：1989-06-06

Applicant: ABBOTT LAB

Inventor： KLEIN LARRY L ,  MARING CLARENCE J ,  LARTEY PAUL A ,  PARIZA RICHARD J

IPC: A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61K31/7052 ,  A61P31/00 ,  A61P31/04 ,  C07H17/08 ,  C07H19/04 ,  A61K31/71

Abstract: Semisynthetic antibiotics with improved therapeutic properties are disclosed. In particular, 9-R-azacyclic derivatives of erythromycin, its derivatives, and their salts and esters show superior antimicrobial activity compared to other macrolide compounds.

公开(公告)号：DE69418715T2

公开(公告)日：1999-12-16

申请号：DE69418715

申请日：1994-07-06

Applicant: ABBOTT LAB

Inventor： EDWARDS CARLA ,  LARTEY PAUL A

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

Abstract: Antibacterial compounds having the formula and pharmaceutically acceptable salts thereof, wherein Y is selected from isting of -C(O)-, -C(S)-, -CH2-, -CH2CH2- and -C(CH3)2-; also disclosed are processes and intermediates useful in the preparation of the above compounds, as well as compositions containing the same and methods for their use.