公开(公告)号：GR862328B

公开(公告)日：1987-01-19

申请号：GR860102328

申请日：1986-09-11

Applicant: ABBOTT LAB

Inventor： WILLIAM BROWN E ,  JOHN CLEMENS M ,  DEVEREAUX SHARON M ,  KNIGGE KEVIN M ,  SAFFORD SARAH E ,  HOFLER JOHN G

IPC: G01N33/548 ,  G01N31/22 ,  G01N33/52 ,  G01N33/543 ,  G01N33/546 ,  G01N33/569 ,  G01N33/576 ,  G01N33/76

Abstract: A novel material and device useful in solid-phase binding assays to determine the presence or amount of an analyte in a test sample, particularly antigens or antibodies, is disclosed. The material comprises a porous matrix of fibers and a plurality of substantially spherical, solid particles having an average diameter of from about 0.1 to about 5 microns. The particles are retained and immobilized upon the fibers of the matrix. Preferably, the particles have on their surfaces a substance capable of reaction with the analyte in the sample, and the average diameter of the particles is less than the average pore size of the matrix. The device, in a preferred embodiment, comprises a substantially planar layer of the described material.