公开(公告)号：CA2235607C

公开(公告)日：2003-05-13

申请号：CA2235607

申请日：1996-10-18

Applicant: ABBOTT LAB

Inventor： SALEKI-GERHARDT AZITA ,  KESKE ERNEST R

IPC: A61K9/16 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61K47/32 ,  A61K31/71 ,  B01J2/00

Abstract: The prevent invention provides a process for the aqueous granulation of a macrolide antibiotic which comprises mixing a macrolide antibiotic and a carbomer; wetting the mixture with water; and blending the mixture to allow formation of a macrolide antibiotic-carbomer granule.

公开(公告)号：AU706837B2

公开(公告)日：1999-06-24

申请号：AU7517696

申请日：1996-10-18

Applicant: ABBOTT LAB

Inventor： SALEKI-GERHARDT AZITA ,  KESKE ERNEST R

IPC: A61K9/16 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61K47/32

Abstract: The present invention provides a process for the aqueous granulation of a macrolide antibiotic which comprises mixing a macrolide antibiotic and a carbomer; wetting the mixture with water; and blending the mixture to allow formation of a macrolide antibiotic-carbomer granule.

公开(公告)号：MX9803480A

公开(公告)日：1998-09-30

申请号：MX9803480

申请日：1998-04-30

Applicant: ABBOTT LAB

Inventor： SALEKI-GERHARDT AZITA ,  KESKE ERNEST R

IPC: A61K9/16 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61K47/32 ,  A61K09/16

Abstract: La presente invencion provee un procedimiento para la granulacion en humedo de un antibiotico de macrolido, el cual comprende mezclar un antibiotico de macrolido y un carbomero; humedecer la mezcla con agua; y combinar la mezcla para permitir la formacion de un gránulo de antibiotico de macrolido-carbomero.

公开(公告)号：AU3075692A

公开(公告)日：1993-07-28

申请号：AU3075692

申请日：1992-11-16

Applicant: ABBOTT LAB

Inventor： SCOIK KURT G VAN ,  KESKE ERNEST R ,  CIPOLLO KENT L ,  WEIS JEFFERY K

IPC: A61K9/20 ,  A61K9/28 ,  A61K9/14

Abstract: Dietetic formulations for oral use are described, made up of tablets formed from dense granules of mixtures of keto- or hydroxy-amino acid analogs, possibly coated by protective films, which are dissolved in the gastrointestinal juices. The process for obtaining dense granules includes a coordinated increase in pressure being maintained for a substantial period of time and subsequent tableting and possible coating by immersion or spraying of the granular material.

公开(公告)号：ES2200075T3

公开(公告)日：2004-03-01

申请号：ES96937699

申请日：1996-10-18

Applicant: ABBOTT LAB

Inventor： SALEKI-GERHARDT AZITA ,  KESKE ERNEST R

IPC: A61K9/16 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61K47/32

Abstract: The present invention provides a process for the aqueous granulation of a macrolide antibiotic which comprises mixing a macrolide antibiotic and a carbomer; wetting the mixture with water; and blending the mixture to allow formation of a macrolide antibiotic-carbomer granule.

公开(公告)号：PT858324E

公开(公告)日：2003-10-31

申请号：PT96937699

申请日：1996-10-18

Applicant: ABBOTT LAB

Inventor： SALEKI-GERHARD AZITA ,  KESKE ERNEST R

IPC: A61K9/16 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61K47/32

Abstract: The present invention provides a process for the aqueous granulation of a macrolide antibiotic which comprises mixing a macrolide antibiotic and a carbomer; wetting the mixture with water; and blending the mixture to allow formation of a macrolide antibiotic-carbomer granule.

公开(公告)号：AT241963T

公开(公告)日：2003-06-15

申请号：AT96937699

申请日：1996-10-18

Applicant: ABBOTT LAB

Inventor： SALEKI-GERHARDT AZITA ,  KESKE ERNEST R

IPC: A61K9/16 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61K47/32

Abstract: The present invention provides a process for the aqueous granulation of a macrolide antibiotic which comprises mixing a macrolide antibiotic and a carbomer; wetting the mixture with water; and blending the mixture to allow formation of a macrolide antibiotic-carbomer granule.

公开(公告)号：CA2235607A1

公开(公告)日：1997-05-09

申请号：CA2235607

申请日：1996-10-18

Applicant: ABBOTT LAB

Inventor： KESKE ERNEST R ,  SALEKI-GERHARDT AZITA

IPC: A61K9/16 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61K47/32 ,  A61K31/71 ,  B01J2/00

Abstract: The prevent invention provides a process for the aqueous granulation of a macrolide antibiotic which comprises mixing a macrolide antibiotic and a carbomer; wetting the mixture with water; and blending the mixture to allow formation of a macrolide antibiotic-carbomer granule.