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    3.
    发明专利
    未知

    公开(公告)号：AT231974T

    公开(公告)日：2003-02-15

    申请号：AT95939513

    申请日：1995-10-06

    Applicant: ABBOTT LAB

    Inventor： DOMANIK RICHARD A ,  SOHL GORDON ,  KOTLARIK JOHN ,  ABUNIMEH NOMAN

    IPC: G01N35/10

    Abstract: The present invention relates to a method for verifying dispense of a fluid from a dispense nozzle, the method comprising the steps of: providing a source of electromagnetic radiation and a receiver of the electromagnetic radiation from the source of electromagnetic radiation, such that the flow of a fluid from the nozzle passes through a path of electromagnetic radiation from the source to the receiver; energizing the source such that the source produces electromagnetic radiation; illuminating the receiver with the electromagnetic radiation; generating with the receiver a first signal; setting a threshold based on the first signal; dispensing fluid from the dispense nozzle; obstructing the electromagnetic signal between the source and the receiver with the fluid dispensed from the dispense nozzle; generating with the receiver a second signal; comparing the threshold and the second signal substantially continuously to indicate start of a dispense of fluid from the dispense nozzle; generating with the receiver a third signal; comparing the third signal and the threshold to indicate finish of a dispense of fluid from the dispense nozzle; determining a first time period between generation of the second signal and generation of the third signal; determining a second time period of an expected temporal duration between start and finish of the dispense of fluid from the dispense nozzle; and comparing the first time period and the second time period to verify the dispense of fluid from the dispense nozzle. .

    4.
    发明专利
    未知

    公开(公告)号：AT417277T

    公开(公告)日：2008-12-15

    申请号：AT02000782

    申请日：1995-10-06

    Applicant: ABBOTT LAB

    Inventor： DOMANIK RICHARD A ,  SOHL GORDON ,  KOTLARIK JOHN ,  ABUNIMEH NOMAN

    IPC: G01N35/10

    Abstract: The present invention relates to a method for verifying dispense of a fluid from a dispense nozzle, the method comprising the steps of: providing a source of electromagnetic radiation and a receiver of the electromagnetic radiation from the source of electromagnetic radiation, such that the flow of a fluid from the nozzle passes through a path of electromagnetic radiation from the source to the receiver; energizing the source such that the source produces electromagnetic radiation; illuminating the receiver with the electromagnetic radiation; generating with the receiver a first signal; setting a threshold based on the first signal; dispensing fluid from the dispense nozzle; obstructing the electromagnetic signal between the source and the receiver with the fluid dispensed from the dispense nozzle; generating with the receiver a second signal; comparing the threshold and the second signal substantially continuously to indicate start of a dispense of fluid from the dispense nozzle; generating with the receiver a third signal; comparing the third signal and the threshold to indicate finish of a dispense of fluid from the dispense nozzle; determining a first time period between generation of the second signal and generation of the third signal; determining a second time period of an expected temporal duration between start and finish of the dispense of fluid from the dispense nozzle; and comparing the first time period and the second time period to verify the dispense of fluid from the dispense nozzle. .

    5.
    发明专利
    未知

    公开(公告)号：DE69529531T2

    公开(公告)日：2003-11-20

    申请号：DE69529531

    申请日：1995-10-06

    Applicant: ABBOTT LAB

    Inventor： DOMANIK A ,  SOHL GORDON ,  KOTLARIK JOHN ,  ABUNIMEH NOMAN

    IPC: G01N35/10

    Abstract: The present invention relates to a method for verifying dispense of a fluid from a dispense nozzle, the method comprising the steps of: providing a source of electromagnetic radiation and a receiver of the electromagnetic radiation from the source of electromagnetic radiation, such that the flow of a fluid from the nozzle passes through a path of electromagnetic radiation from the source to the receiver; energizing the source such that the source produces electromagnetic radiation; illuminating the receiver with the electromagnetic radiation; generating with the receiver a first signal; setting a threshold based on the first signal; dispensing fluid from the dispense nozzle; obstructing the electromagnetic signal between the source and the receiver with the fluid dispensed from the dispense nozzle; generating with the receiver a second signal; comparing the threshold and the second signal substantially continuously to indicate start of a dispense of fluid from the dispense nozzle; generating with the receiver a third signal; comparing the third signal and the threshold to indicate finish of a dispense of fluid from the dispense nozzle; determining a first time period between generation of the second signal and generation of the third signal; determining a second time period of an expected temporal duration between start and finish of the dispense of fluid from the dispense nozzle; and comparing the first time period and the second time period to verify the dispense of fluid from the dispense nozzle. .

    6.
    发明专利
    未知

    公开(公告)号：DE69412632T2

    公开(公告)日：1999-01-14

    申请号：DE69412632

    申请日：1994-09-28

    Applicant: ABBOTT LAB

    Inventor： ZAUN PETER ,  BOUMA STANLEY ,  GORDON JULIAN ,  KOTLARIK JOHN ,  SOLOMON NATALIE

    IPC: B01L3/00 ,  B01L7/00 ,  B01L99/00 ,  C12N15/09 ,  C12Q1/68 ,  G01N1/00 ,  G01N35/00

    Abstract: Methods, devices, apparatus and kits for amplifying and detecting nucleic acid are provided. The apparatus is a one or two-tier thermal cycling device that operates in conjunction with a reaction/detection unit. A sample is loaded into a reaction chamber of the device which is then mated with a detection chamber to form the reaction/detection unit. A first heating element of the thermal cycling apparatus applies a desired temperature to the reaction/detection device to amplify target nucleic acid in the sample. The reaction mixture is then transferred to the detection chamber by the second heating element and amplified target nucleic acid is immobilized on a support in the detection chamber. Microprocessor control controls the heat applied by the second element independently of the heat applied by the first element. A detection system associated with the apparatus detects and analyzes the immobilized amplified nucleic acid target. Images are captured and digitized and subjected to statistical analysis to improve the accuracy of the method.

    METODO PARA VERIFICAR LA DOSIFICACION DE UN FLUIDO.
    8.
    发明专利
    METODO PARA VERIFICAR LA DOSIFICACION DE UN FLUIDO. 未知

    公开(公告)号：ES2316493T3

    公开(公告)日：2009-04-16

    申请号：ES02000782

    申请日：1995-10-06

    Applicant: ABBOTT LAB

    Inventor： DOMANIK RICHARD A ,  SOHL GORDON ,  KOTLARIK JOHN ,  ABUNIMEH NOMAN

    IPC: G01N35/10

    Abstract: Un método para verificar la dosificación de un fluido desde una boquilla de dosificación (14), comprendiendo el método las etapas de: (a) proporcionar una fuente (16) de radiación electromagnética y un receptor (18) de la radiación electromagnética desde la fuente (16) de radiación electromagnética, de manera que el flujo de un fluido (12) desde la boquilla (14) pasa a través de una trayectoria (20) de radiación electromagnética desde la fuente (16) al receptor (18); (b) activar la fuente (16) de manera que la fuente (16) produzca radiación electromagnética; (c) iluminar el receptor (18) con la radiación electromagnética; (d) generar una primera señal con el receptor (18); (e) ajustar un umbral basado en la primera señal, siendo el umbral un porcentaje predeterminado de la primera señal y tal que no se detecte una gota de fluido menor (12), que tiene un volumen insuficiente para influir significativamente de manera negativa en la dosificación de un volumen de fluido pretendido (12), que cuelga de la boquilla de dosificación (14); (f) dosificar fluido (12) desde la boquilla de dosificación (14); (g) obstruir la señal electromagnética entre la fuente (16) y el receptor (18) con el fluido (12) dosificado desde la boquilla de dosificación (14); (h) generar una segunda señal con el receptor (18); (i) comparar el umbral y la segunda señal sustancialmente de manera continua para indicar el inicio de una dosificación de fluido (12) desde la boquilla de dosificación (14); (j) generar una tercera señal con el receptor (18); (k) comparar la tercera señal y el umbral para indicar el final de una dosificación de fluido (12) desde la boquilla de dosificación (14); (l) determinar un primer período de tiempo entre la generación de la segunda señal y la generación de la tercera señal; (m) determinar un segundo período de tiempo de una duración temporal esperada entre el inicio y el final de la dosificación de fluido (12) desde la boquilla de dosificación (14); y (n) comparar el primer período de tiempo y el segundo período de tiempo para verificar la dosificación de fluido (12) desde la boquilla de dosificación (14).

    9.
    发明专利
    未知

    公开(公告)号：DE69535896D1

    公开(公告)日：2009-01-22

    申请号：DE69535896

    申请日：1995-10-06

    Applicant: ABBOTT LAB

    Inventor： DOMANIK RICHARD A ,  SOHL GORDON ,  KOTLARIK JOHN ,  ABUNIMEH NOMAN

    IPC: G01N35/10

    Abstract: The present invention relates to a method for verifying dispense of a fluid from a dispense nozzle, the method comprising the steps of: providing a source of electromagnetic radiation and a receiver of the electromagnetic radiation from the source of electromagnetic radiation, such that the flow of a fluid from the nozzle passes through a path of electromagnetic radiation from the source to the receiver; energizing the source such that the source produces electromagnetic radiation; illuminating the receiver with the electromagnetic radiation; generating with the receiver a first signal; setting a threshold based on the first signal; dispensing fluid from the dispense nozzle; obstructing the electromagnetic signal between the source and the receiver with the fluid dispensed from the dispense nozzle; generating with the receiver a second signal; comparing the threshold and the second signal substantially continuously to indicate start of a dispense of fluid from the dispense nozzle; generating with the receiver a third signal; comparing the third signal and the threshold to indicate finish of a dispense of fluid from the dispense nozzle; determining a first time period between generation of the second signal and generation of the third signal; determining a second time period of an expected temporal duration between start and finish of the dispense of fluid from the dispense nozzle; and comparing the first time period and the second time period to verify the dispense of fluid from the dispense nozzle. .

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