公开(公告)号：EP0588969A4

公开(公告)日：1994-08-17

申请号：EP92914552

申请日：1992-06-12

Applicant: ABBOTT LAB

Inventor： KOTLARIK JOHN J ,  WROBLEWSKI MIECZYSLAW

IPC: G01N21/17 ,  B01L3/00 ,  B01L3/02 ,  G01N15/14 ,  G01N21/82 ,  G01N33/48 ,  G01N33/483 ,  G01N33/543 ,  G01N33/80 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G02B7/28 ,  G06T1/00 ,  G06K9/00

CPC classification number: G01N35/109 ,  B01L3/0262 ,  B01L3/5085 ,  G01N15/1468 ,  G01N21/82 ,  G01N35/0095 ,  G01N35/0098 ,  G01N35/028 ,  G01N35/1004 ,  G01N2035/042 ,  G01N2035/0425 ,  G01N2035/0491 ,  G01N2035/1018 ,  G01N2035/1025 ,  G01N2035/1034 ,  G01N2201/0446 ,  G01N2201/0461 ,  G01N2201/0492 ,  G02B7/28 ,  Y10T137/7306 ,  Y10T436/115831

Abstract: A method for agglutination detection using optical imaging of reaction wells containing agglutination objects in a programmable random access automated apparatus for perforing agglutination assays is provided. An image of the agglutination objects in the reaction wells is taken with analyzation of the intensity values and transitions through relative portions of the image and background which provides intensity values suitable for classifying. The method utilizes slope information from a derivative (Fig. 34 A-E, second row) rather than absolute intensities, thus allowing scoring algorithm based on slope total information. The agglutination detection method uses a CCD camera to take an image at each well (Fig. 34 A-E, first row) of a multiple well cartridge, thus providing information suitable for analyzing from the image detection apparatus, the apparatus processes the information to generate a visual indication of the results of the assays being performed. A micro-processor is provided to assist in the operation of the apparatus as well as the image processing data collection and analysis.

公开(公告)号：EP0588968A4

公开(公告)日：1994-06-22

申请号：EP92914538

申请日：1992-06-12

Applicant: ABBOTT LAB

Inventor： WHITE DAVID A ,  WROBLEWSKI MIECZYSLAW ,  KOTLARIK JOHN J

IPC: G01N21/17 ,  B01L3/00 ,  B01L3/02 ,  G01N15/14 ,  G01N21/82 ,  G01N33/48 ,  G01N33/483 ,  G01N33/543 ,  G01N33/80 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G02B7/28 ,  G06T1/00 ,  G01N21/01

CPC classification number: G01N35/109 ,  B01L3/0262 ,  B01L3/5085 ,  G01N15/1468 ,  G01N21/82 ,  G01N35/0095 ,  G01N35/0098 ,  G01N35/028 ,  G01N35/1004 ,  G01N2035/042 ,  G01N2035/0425 ,  G01N2035/0491 ,  G01N2035/1018 ,  G01N2035/1025 ,  G01N2035/1034 ,  G01N2201/0446 ,  G01N2201/0461 ,  G01N2201/0492 ,  G02B7/28 ,  Y10T137/7306 ,  Y10T436/115831

Abstract: A liquid dispensing mechanism (34) is provided which includes a dispensing probe having a tip (70) for dispensing liquid, a pump for collectively discharging fluid from the probe tip (70) in measured quantities such as droplets. The dispensing probe has the capability to detect droplet formation and droplet separation from the probe (70) through use of a radio-frequency signal (74, 76) to the probe tip (70) and a conductive element (72) connected to amplifying and analyzing circuitry (78, 80, 82, 84) disposed below the dispensing probe (70) and a reaction well (16) which contains a receiving fluid. The conductive element (72) also detects when the probe has been inserted into the receiving fluid.

公开(公告)号：EP0588931A4

公开(公告)日：1994-06-22

申请号：EP92913497

申请日：1992-06-11

Applicant: ABBOTT LAB

Inventor： CHOW HERBERT S ,  WILSON THOMAS J ,  WROBLEWSKI MIECZYSLAW ,  KOTLARIK JOHN J ,  ALSBERG KEITH D ,  MCCOY JIMMY D ,  LADD JIMMY L ,  CORBETT KEVIN M

IPC: G01N21/17 ,  B01L3/00 ,  B01L3/02 ,  G01N15/14 ,  G01N21/82 ,  G01N33/48 ,  G01N33/483 ,  G01N33/543 ,  G01N33/80 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G02B7/28 ,  G06T1/00 ,  G01N21/01

CPC classification number: G01N35/109 ,  B01L3/0262 ,  B01L3/5085 ,  G01N15/1468 ,  G01N21/82 ,  G01N35/0095 ,  G01N35/0098 ,  G01N35/028 ,  G01N35/1004 ,  G01N2035/042 ,  G01N2035/0425 ,  G01N2035/0491 ,  G01N2035/1018 ,  G01N2035/1025 ,  G01N2035/1034 ,  G01N2201/0446 ,  G01N2201/0461 ,  G01N2201/0492 ,  G02B7/28 ,  Y10T137/7306 ,  Y10T436/115831

Abstract: An apparatus is provided for moving a reaction cartridge (10) to different processing areas (36, 38, 42) of the apparatus. Robots (34, 40) for moving the reaction cartridge to the various areas (30, 32, 36, 38, 42, 46) of the apparatus. An image forming device (42) is provided to detect images which indicate whether specific reactions have occurred in reaction wells (16) of the reaction cartridge (10). The apparatus also includes a mechanism (36) for aspirating and dispensing liquids which includes a liquid level detecting mechanism (70, 72, 74, 76, 78, 80, 82, 84). The device further includes a microprocessor and logic (44) for controlling the apparatus operation and analyzing the information received from the image forming device (42) to generate a visual indication of assay results.

公开(公告)号：AT223034T

公开(公告)日：2002-09-15

申请号：AT96905157

申请日：1996-01-17

Applicant: ABBOTT LAB

Inventor： VIEGUT TODD E ,  KOTLARIK JOHN ,  WROBLEWSKI MIECZYSLAW ,  SLESZYNSKI NEAL T ,  FOWLER JOHN PAUL ,  SCHAPIRA THOMAS GERARD ,  SMITH KENNETH CHARLES

IPC: G01F17/00 ,  G01F22/00 ,  G01F23/26 ,  G01F23/284 ,  G01N35/10

公开(公告)号：CA2211355A1

公开(公告)日：1996-08-08

申请号：CA2211355

申请日：1996-01-17

Applicant: ABBOTT LAB

Inventor： KOTLARIK JOHN ,  SMITH KENNETH CHARLES ,  VIEGUT TODD E ,  SCHAPIRA THOMAS GERARD ,  SLESZYNSKI NEAL T ,  WROBLEWSKI MIECZYSLAW ,  FOWLER JOHN PAUL

IPC: G01F17/00 ,  G01F22/00 ,  G01F23/26 ,  G01F23/284 ,  G01N35/10

公开(公告)号：DE69623259T2

公开(公告)日：2003-05-28

申请号：DE69623259

申请日：1996-01-17

Applicant: ABBOTT LAB

Inventor： VIEGUT E ,  KOTLARIK JOHN ,  WROBLEWSKI MIECZYSLAW ,  SLESZYNSKI T ,  FOWLER PAUL ,  SCHAPIRA GERARD ,  SMITH CHARLES

IPC: G01F17/00 ,  G01F22/00 ,  G01F23/26 ,  G01F23/284 ,  G01N35/10

公开(公告)号：CA2211355C

公开(公告)日：2001-03-27

申请号：CA2211355

申请日：1996-01-17

Applicant: ABBOTT LAB

Inventor： VIEGUT TODD E ,  KOTLARIK JOHN ,  FOWLER JOHN PAUL ,  SCHAPIRA THOMAS GERARD ,  WROBLEWSKI MIECZYSLAW ,  SMITH KENNETH CHARLES ,  SLESZYNSKI NEAL T

IPC: G01F17/00 ,  G01F22/00 ,  G01F23/26 ,  G01F23/284 ,  G01N35/10

公开(公告)号：DE69623259D1

公开(公告)日：2002-10-02

申请号：DE69623259

申请日：1996-01-17

Applicant: ABBOTT LAB

Inventor： VIEGUT E ,  KOTLARIK JOHN ,  WROBLEWSKI MIECZYSLAW ,  SLESZYNSKI T ,  FOWLER PAUL ,  SCHAPIRA GERARD ,  SMITH CHARLES

IPC: G01F17/00 ,  G01F22/00 ,  G01F23/26 ,  G01F23/284 ,  G01N35/10

公开(公告)号：ES2095203T3

公开(公告)日：1997-02-16

申请号：ES88103398

申请日：1988-03-04

Applicant: ABBOTT LAB

Inventor： HOUSEMAN KENNETH RUSSELL ,  WENDER DAVID C ,  BANOVEZ LAWRENCE GEORGE ,  WROBLEWSKI MIECZYSLAW

IPC: G01N21/27 ,  G01J3/12 ,  G01N21/25 ,  G01N21/59 ,  G01N21/47 ,  G01N33/53 ,  G01N33/543

Abstract: A vertical beam spectrophotometer for measuring the light absorption of an assay prepared using standard wet chemistry procedures and conventional solid phase coated bead technology is disclosed. The spectrophotometer measures the absorption of the assay in a conventional reaction cuvette with the bead remaining in the cuvette. The light source of the spectrophotometer illuminates the bead, which diffuses the light into the surrounding assay solution. A lense projects the diffused light onto a photocell which converts it into an electrical signal having magnitude related to the light absorption of the assay. The signal is processed in a known manner by conventional processing circuitry to obtain an absorption value.

公开(公告)号：DE3855614D1

公开(公告)日：1996-11-21

申请号：DE3855614

申请日：1988-03-04

Applicant: ABBOTT LAB

Inventor： HOUSEMAN KENNETH RUSSELL ,  WENDER DAVID C ,  BANOVEZ LAWRENCE GEORGE ,  WROBLEWSKI MIECZYSLAW

IPC: G01N21/27 ,  G01J3/12 ,  G01N21/25 ,  G01N21/59 ,  G01N21/47 ,  G01N33/53 ,  G01N33/543

Abstract: A vertical beam spectrophotometer for measuring the light absorption of an assay prepared using standard wet chemistry procedures and conventional solid phase coated bead technology is disclosed. The spectrophotometer measures the absorption of the assay in a conventional reaction cuvette with the bead remaining in the cuvette. The light source of the spectrophotometer illuminates the bead, which diffuses the light into the surrounding assay solution. A lense projects the diffused light onto a photocell which converts it into an electrical signal having magnitude related to the light absorption of the assay. The signal is processed in a known manner by conventional processing circuitry to obtain an absorption value.