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1.发明申请METHODS OF PREPARATION OF RECOMBINANT FORMS OF HUMAN BETA-AMYLOID PROTEIN AND USES OF THESE PROTEINS 审中-公开人β-淀粉样蛋白重组体的制备方法和这些蛋白质的使用
公开(公告)号：WO2007064917A2
公开(公告)日：2007-06-07
申请号：PCT/US2006046043
申请日：2006-11-30
Applicant: ABBOTT LAB , ABBOTT GMBH & CO KG , HOLZMAN THOMAS F , HARLAN JOHN E , EDALJI ROHINTON P , OLEJNICZAK EDWARD T , PERADA-LOPEZ ANA , LABKVOSKY BORIS , YU LIPING
Inventor： HOLZMAN THOMAS F , HARLAN JOHN E , EDALJI ROHINTON P , OLEJNICZAK EDWARD T , PERADA-LOPEZ ANA , LABKVOSKY BORIS , YU LIPING
IPC: C07K14/43
CPC classification number: C07K14/4711 , A61K38/00 , C07K16/18
Abstract: The subject invention relates to the cloning, expression and isolation of recombinant forms of beta-amyloid protein containing a N-terminal methionine (or one or more amino acids) as well as to methods of using this recombinant protein in the production of therapeutic antibodies, in the identification of therapeutic small molecules, and in the performance of diagnostic assays.
Abstract translation: 本发明涉及含有N-末端甲硫氨酸（或一种或多种氨基酸）的重组形式的β-淀粉样蛋白的克隆，表达和分离以及在制备治疗性抗体中使用该重组蛋白的方法， 在鉴定治疗性小分子时，以及在诊断测定中的表现。
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Patent Agency Ranking
公开(公告)号：WO2007064972A3
公开(公告)日：2007-11-01
申请号：PCT/US2006046148
申请日：2006-11-30
Applicant: ABBOTT LAB , ABBOTT GMBH & CO KG , LABKVOSKY BORIS , BARGHORN STEFAN , HILLEN HEINZ , EBERT ULRICH , STRIEBINGER ANDREAS R , KELLER PATRICK
Inventor： LABKVOSKY BORIS , BARGHORN STEFAN , HILLEN HEINZ , EBERT ULRICH , STRIEBINGER ANDREAS R , KELLER PATRICK
IPC: C07K16/18 , A61K39/395 , A61P25/28 , C12N5/18 , C12N15/13 , G01N33/53 , G01N33/577
CPC classification number: C07K16/18 , A61K2039/505 , C07K2317/14 , C07K2317/20 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/92 , G01N33/577 , G01N33/6896 , G01N2333/4709 , G01N2500/20 , G01N2800/2821
Abstract: The subject invention relates to monoclonal antibodies (e.g., 8F5 and 8C5) that may be used, for example, in the prevention, treatment and diagnosis of Alzheimer's Disease or other neurodegenerative disorders.
Abstract translation: 本发明涉及可用于例如预防，治疗和诊断阿尔茨海默病或其它神经变性疾病的单克隆抗体（例如8F5和8C5）。
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3.发明专利
公开(公告)号：CA2637472A1
公开(公告)日：2007-06-07
申请号：CA2637472
申请日：2006-11-30
Applicant: ABBOTT GMBH & CO KG , ABBOTT LAB
Inventor： EDALJI ROHINTON P , HARLAN JOHN E , HOLZMAN THOMAS F , YU LIPING , PERADA-LOPEZ ANA , LABKVOSKY BORIS , OLEJNICZAK EDWARD T
Abstract: The subject invention relates to the cloning, expression and isolation of recombinant forms of beta-amyloid protein containing a N-terminal methionine (or one or more amino acids) as well as to methods of using this recombinant protein in the production of therapeutic antibodies, in the identification of therapeutic small molecules, and in the performance of diagnostic assays.
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公开(公告)号：CA2631195A1
公开(公告)日：2007-06-07
申请号：CA2631195
申请日：2006-11-30
Applicant: ABBOTT GMBH & CO KG , ABBOTT LAB
Inventor： STRIEBINGER ANDREAS R , HILLEN HEINZ , BARGHORN STEFAN , LABKVOSKY BORIS , EBERT ULRICH , KELLER PATRICK
IPC: C07K16/18 , A61K39/395 , A61P25/28 , C12N5/18 , C12N15/13 , G01N33/53 , G01N33/577
Abstract: The subject invention relates to monoclonal antibodies (e.g., 8F5 and 8C5) that may be used, for example, in the prevention, treatment, and diagnosis of Alzheimer's Disease or other neurodegenerative disorders.
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公开(公告)号：MX2008006957A
公开(公告)日：2008-10-20
申请号：MX2008006957
申请日：2006-11-30
Applicant: ABBOTT LAB
Inventor： HOLZMAN THOMAS F , HARLAN JOHN E , EDALJI ROHINTON P , OLEJNICZAK EDWARD T , PERADA-LOPEZ ANA , LABKVOSKY BORIS , YU LIPING
Abstract: La presente invención se refiere a la clonación, expresión y aislamiento de formas recombinantes de proteína beta-amiloide conteniendo una metionina N-terminal (o uno o más aminoácidos) así como a métodos para utilizar esta proteína recombinante en la producción de anticuerpos terapéuticos, en la identificación de moléculas pequeñas terapéuticas, y en la realización de ensayos de diagnóstico.
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公开(公告)号：AU2006320392A1
公开(公告)日：2007-06-07
申请号：AU2006320392
申请日：2006-11-30
Applicant: ABBOTT LAB , ABBOTT GMBH & CO KG
Inventor： BARGHORN STEFAN , HILLEN HEINZ , EBERT ULRICH , LABKVOSKY BORIS , STRIEBINGER ANDREAS R , KELLER PATRICK
IPC: C07K16/18 , A61K39/395 , A61P25/28 , C12N5/18 , C12N15/13 , G01N33/53 , G01N33/577
Abstract: The subject invention relates to monoclonal antibodies (e.g., 8F5 and 8C5) that may be used, for example, in the prevention, treatment, and diagnosis of Alzheimer's Disease or other neurodegenerative disorders.
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