公开(公告)号：WO2007064917A2

公开(公告)日：2007-06-07

申请号：PCT/US2006046043

申请日：2006-11-30

Applicant: ABBOTT LAB ,  ABBOTT GMBH & CO KG ,  HOLZMAN THOMAS F ,  HARLAN JOHN E ,  EDALJI ROHINTON P ,  OLEJNICZAK EDWARD T ,  PERADA-LOPEZ ANA ,  LABKVOSKY BORIS ,  YU LIPING

Inventor： HOLZMAN THOMAS F ,  HARLAN JOHN E ,  EDALJI ROHINTON P ,  OLEJNICZAK EDWARD T ,  PERADA-LOPEZ ANA ,  LABKVOSKY BORIS ,  YU LIPING

IPC: C07K14/43

CPC classification number: C07K14/4711 ,  A61K38/00 ,  C07K16/18

Abstract: The subject invention relates to the cloning, expression and isolation of recombinant forms of beta-amyloid protein containing a N-terminal methionine (or one or more amino acids) as well as to methods of using this recombinant protein in the production of therapeutic antibodies, in the identification of therapeutic small molecules, and in the performance of diagnostic assays.

Abstract translation: 本发明涉及含有N-末端甲硫氨酸（或一种或多种氨基酸）的重组形式的β-淀粉样蛋白的克隆，表达和分离以及在制备治疗性抗体中使用该重组蛋白的方法， 在鉴定治疗性小分子时，以及在诊断测定中的表现。

公开(公告)号：MX2008006957A

公开(公告)日：2008-10-20

申请号：MX2008006957

申请日：2006-11-30

Applicant: ABBOTT LAB

Inventor： HOLZMAN THOMAS F ,  HARLAN JOHN E ,  EDALJI ROHINTON P ,  OLEJNICZAK EDWARD T ,  PERADA-LOPEZ ANA ,  LABKVOSKY BORIS ,  YU LIPING

IPC: C07K14/47 ,  A61P25/00 ,  C07K16/18 ,  G01N33/53

Abstract: La presente invención se refiere a la clonación, expresión y aislamiento de formas recombinantes de proteína beta-amiloide conteniendo una metionina N-terminal (o uno o más aminoácidos) así como a métodos para utilizar esta proteína recombinante en la producción de anticuerpos terapéuticos, en la identificación de moléculas pequeñas terapéuticas, y en la realización de ensayos de diagnóstico.

公开(公告)号：CA2219931C

公开(公告)日：2012-05-15

申请号：CA2219931

申请日：1996-05-24

Applicant: ABBOTT LAB

Inventor： GRENIER FRANK ,  HOLZMAN THOMAS F ,  SMITH ALLAN H ,  TSURUTANI ALAN C

IPC: A61K47/42 ,  G01N33/531 ,  A61K31/436 ,  A61K31/7052 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  G01N33/94 ,  G01N33/96

Abstract: The present invention is directed to an in vitro aqueous composition comprising a drug, preferably tacrolimus or rapamycin, having enhanced stability. The invention utilizes a binding protein, preferably FKBP, to stabilize the drug in an aqueous matrix.

公开(公告)号：CA2365300A1

公开(公告)日：2000-09-21

申请号：CA2365300

申请日：2000-03-01

Applicant: ABBOTT LAB

Inventor： BUKO ALEXANDER M ,  TANG QING ,  LADROR URI S ,  SOLOMON LARRY R ,  HOLZMAN THOMAS F ,  HARLAN JOHN E ,  EGAN DAVID A

IPC: G01N33/50 ,  C12Q1/02 ,  C12Q1/68 ,  C12Q1/70 ,  C40B30/00 ,  C40B40/02 ,  C40B50/06 ,  G01N33/15 ,  G01N33/53 ,  G01N33/567

Abstract: Centrifugation is used to induce and/or enhance binding between macromolecul ar targets and either small-molecule ligands or larger biomolecules as single entities or mixtures. With the enhanced binding, the method of the invention permits detection of ligands that bind to target substances and improve the design of ligands. The process relies on centrifugal force to establish a differential and selective concentration gradient between macromolecular therapeutic targets and the desired ligands. Once formed, the information about the self-sorting binding events is derived by analyzing the differenti al gradient of macromolecules and ligands in situ or by fractionating the gradient into individual samples for independent analysis. A variety of methods or combinations thereof, can be used to look for enhanced levels of bound ligands.

公开(公告)号：CA2637472A1

公开(公告)日：2007-06-07

申请号：CA2637472

申请日：2006-11-30

Applicant: ABBOTT GMBH & CO KG ,  ABBOTT LAB

Inventor： EDALJI ROHINTON P ,  HARLAN JOHN E ,  HOLZMAN THOMAS F ,  YU LIPING ,  PERADA-LOPEZ ANA ,  LABKVOSKY BORIS ,  OLEJNICZAK EDWARD T

IPC: C07K14/47 ,  A61P25/00 ,  C07K16/18 ,  G01N33/53

Abstract: The subject invention relates to the cloning, expression and isolation of recombinant forms of beta-amyloid protein containing a N-terminal methionine (or one or more amino acids) as well as to methods of using this recombinant protein in the production of therapeutic antibodies, in the identification of therapeutic small molecules, and in the performance of diagnostic assays.

公开(公告)号：ES2176459T3

公开(公告)日：2002-12-01

申请号：ES96916602

申请日：1996-05-24

Applicant: ABBOTT LAB

Inventor： GRENIER FRANK ,  HOLZMAN THOMAS F ,  SMITH ALLAN H ,  TSURUTANI ALAN C

IPC: G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  G01N33/531 ,  G01N33/94 ,  G01N33/96 ,  G01N33/536

Abstract: The present invention is directed to an in vitro aqueous composition comprising a drug, preferably tacrolimus or rapamycin, having enhanced stability. The invention utilizes a binding protein, preferably antibodies to tacrolimus or rapamycin, to stabilize the drug in an aqueous matrix.

公开(公告)号：AT214803T

公开(公告)日：2002-04-15

申请号：AT96916602

申请日：1996-05-24

Applicant: ABBOTT LAB

Inventor： GRENIER FRANK ,  HOLZMAN THOMAS F ,  SMITH ALLAN H ,  TSURUTANI ALAN C

IPC: G01N33/531 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  G01N33/94 ,  G01N33/96 ,  G01N33/536

Abstract: The present invention is directed to an in vitro aqueous composition comprising a drug, preferably tacrolimus or rapamycin, having enhanced stability. The invention utilizes a binding protein, preferably antibodies to tacrolimus or rapamycin, to stabilize the drug in an aqueous matrix.

公开(公告)号：CA2219931A1

公开(公告)日：1996-12-19

申请号：CA2219931

申请日：1996-05-24

Applicant: ABBOTT LAB

Inventor： TSURUTANI ALAN C ,  HOLZMAN THOMAS F ,  GRENIER FRANK ,  SMITH ALLAN H

IPC: G01N33/531 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  G01N33/94 ,  G01N33/96

Abstract: The present invention is directed to an in vitro aqueous composition comprising a drug, preferably tacrolimus or rapamycin, having enhanced stability. The invention utilizes a binding protein, preferably FKBP, to stabilize the drug in an aqueous matrix.

公开(公告)号：CA1312544C

公开(公告)日：1993-01-12

申请号：CA586454

申请日：1988-12-20

Applicant: ABBOTT LAB

Inventor： DEVEREAUX SHARON M ,  WILCOX JAMES L ,  HOLZMAN THOMAS F ,  GORDON JULIAN ,  CHING SHANFUN

IPC: G01N30/88 ,  G01N30/90 ,  G01N33/543 ,  G01N37/00 ,  G01N33/558

Abstract: An assay device, method and kit for detecting or quantitating an analyte in a test sample containing or suspected of containing an analyte of interest. The analytical device comprises a chromatographic material containing a capture reagent, immobilized in a capture situs, and an application pad which receives the test sample and contains a diffusive indicator reagent capable of migrating from the application pad to the chromatographic material. The binding of the indicator reagent results in a detectable signal. Preferably, the device includes all of the reagents necessary to perform the assay. 33