公开(公告)号：KR800000905B1

公开(公告)日：1980-09-10

申请号：KR760002838

申请日：1976-11-13

Applicant: ABBOTT LAB

Inventor： LEE CHUK MAN ,  ZAUGG H ,  PLOTNIKOFF N ,  MICHAELS R

IPC: C07D213/30 ,  C07D213/55

Abstract: The title compds. (I; R1=H, lower alkanoyl; R2=C1-20 straight or side chain alkyl; X=nitrogen or C-methyl), useful as analgesics, were prepd. by reaction of liquid ammonia and isopropenyl derivs. (IV) obtained from dehydration of diacetyl deriv. with thionyl chloride. Diacetyl deriv. was prepared by reaction of anhydrous acetic acid and alcohol(III) obtained from benzopyranone(II) and methyl magnesium bromide in tetrahydrofuran.