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公开(公告)号：CA2281734A1
公开(公告)日：1998-09-03
申请号：CA2281734
申请日：1998-02-06
Applicant: ABBOTT LAB
Inventor： CHU DANIEL T , HSIAO CHI-NUNG W , LI-QUN , KERDESKY FRANCIS A J , WANG WEI-BO
IPC: C07D455/02
Abstract: A process for the preparation of a compound having formula (a) wherein R1, R2, R3, R4, and R5 are defined, from an enamine by chain expansion and ring closure followed by additional derivatization, treatment with a 3-alkoxyl-acryloyl compound, another ring closure, and converting a hydroxyl group to a leaving group.
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