公开(公告)号：CA2032228A1

公开(公告)日：1991-06-23

申请号：CA2032228

申请日：1990-12-13

Applicant: ABBOTT LAB

Inventor： KOLACZKOWSKI LAWRENCE ,  LITTLEFIELD MARK

IPC: G01N33/52 ,  A61K49/00 ,  C07D227/00 ,  C07D493/10 ,  C07K14/435 ,  C07K14/76 ,  C07K14/765 ,  C09B11/08 ,  C09B11/28 ,  C09B29/12 ,  G01N33/53 ,  G01N33/533

Abstract: A substituted monoethylglycinexylidide or analogue is disclosed. The xylidide or analogue has the structure of Fig. 1 of the attached drawings where M is CH2NHCH2CH3, CH2CH2CH2CH3 or CH2OCH2CH3, one of Y1 and Y2 is H and the other is a protein or a fluorescein moiety chemically bonded to the glycinexylidide or analogue moiety. Also disclosed is a method for carrying out immunoassays for MEGX, which has the structure of Fig. 3 of the attached drawings. The method for carrying out immunoassays involves using the foregoing compounds as tracers and immunogens. 21

公开(公告)号：DE69012541T2

公开(公告)日：1995-03-23

申请号：DE69012541

申请日：1990-12-21

Applicant: ABBOTT LAB

Inventor： KOLACZKOWSKI LAWRENCE ,  LITTLEFIELD MARK

IPC: G01N33/52 ,  A61K49/00 ,  C07D227/00 ,  C07D493/10 ,  C07K14/435 ,  C07K14/76 ,  C07K14/765 ,  C09B11/08 ,  C09B11/28 ,  C09B29/12 ,  G01N33/53 ,  G01N33/533

Abstract: A substituted monoethylglycinexylidide or analogue is disclosed. The xylidide or analogue has the structure of Fig. 1 of the attached drawings where M is CH2NHCH2CH3, CH2CH2CH2CH3 or CH2OCH2CH3, one of Y and Y is H and the other is a protein or a fluorescein moiety chemically bonded to the glycinexylidide or analogue moiety. Also disclosed is a method for carrying out immunoassays for MEGX, which has the structure of Fig. 3 of the attached drawings. The method for carrying out immunoassays involves using the foregoing compounds as tracers and immunogens.

公开(公告)号：ES2063890T3

公开(公告)日：1995-01-16

申请号：ES90125063

申请日：1990-12-21

Applicant: ABBOTT LAB

Inventor： KOLACZKOWSKI LAWRENCE ,  LITTLEFIELD MARK

IPC: G01N33/52 ,  A61K49/00 ,  C07D227/00 ,  C07D493/10 ,  C07K14/435 ,  C07K14/76 ,  C07K14/765 ,  C09B11/08 ,  C09B11/28 ,  C09B29/12 ,  G01N33/53 ,  C07K15/06 ,  G01N33/533

Abstract: A substituted monoethylglycinexylidide or analogue is disclosed. The xylidide or analogue has the structure of Fig. 1 of the attached drawings where M is CH2NHCH2CH3, CH2CH2CH2CH3 or CH2OCH2CH3, one of Y and Y is H and the other is a protein or a fluorescein moiety chemically bonded to the glycinexylidide or analogue moiety. Also disclosed is a method for carrying out immunoassays for MEGX, which has the structure of Fig. 3 of the attached drawings. The method for carrying out immunoassays involves using the foregoing compounds as tracers and immunogens.

公开(公告)号：DE69012541D1

公开(公告)日：1994-10-20

申请号：DE69012541

申请日：1990-12-21

Applicant: ABBOTT LAB

Inventor： KOLACZKOWSKI LAWRENCE ,  LITTLEFIELD MARK

IPC: G01N33/52 ,  A61K49/00 ,  C07D227/00 ,  C07D493/10 ,  C07K14/435 ,  C07K14/76 ,  C07K14/765 ,  C09B11/08 ,  C09B11/28 ,  C09B29/12 ,  G01N33/53 ,  C07K15/06 ,  G01N33/533

Abstract: A substituted monoethylglycinexylidide or analogue is disclosed. The xylidide or analogue has the structure of Fig. 1 of the attached drawings where M is CH2NHCH2CH3, CH2CH2CH2CH3 or CH2OCH2CH3, one of Y and Y is H and the other is a protein or a fluorescein moiety chemically bonded to the glycinexylidide or analogue moiety. Also disclosed is a method for carrying out immunoassays for MEGX, which has the structure of Fig. 3 of the attached drawings. The method for carrying out immunoassays involves using the foregoing compounds as tracers and immunogens.

公开(公告)号：AT111489T

公开(公告)日：1994-09-15

申请号：AT90125063

申请日：1990-12-21

Applicant: ABBOTT LAB

Inventor： KOLACZKOWSKI LAWRENCE ,  LITTLEFIELD MARK

IPC: G01N33/52 ,  A61K49/00 ,  C07D227/00 ,  C07D493/10 ,  C07K14/435 ,  C07K14/76 ,  C07K14/765 ,  C09B11/08 ,  C09B11/28 ,  C09B29/12 ,  G01N33/53 ,  C07K15/06 ,  G01N33/533

Abstract: A substituted monoethylglycinexylidide or analogue is disclosed. The xylidide or analogue has the structure of Fig. 1 of the attached drawings where M is CH2NHCH2CH3, CH2CH2CH2CH3 or CH2OCH2CH3, one of Y and Y is H and the other is a protein or a fluorescein moiety chemically bonded to the glycinexylidide or analogue moiety. Also disclosed is a method for carrying out immunoassays for MEGX, which has the structure of Fig. 3 of the attached drawings. The method for carrying out immunoassays involves using the foregoing compounds as tracers and immunogens.