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    IMMUNOASSAY OF ANALYTES IN SAMPLES CONTAINING ENDOGENOUS ANTI-ANALYTE ANTIBODIES
    1.
    发明申请
    IMMUNOASSAY OF ANALYTES IN SAMPLES CONTAINING ENDOGENOUS ANTI-ANALYTE ANTIBODIES 审中-公开
    含有内源性抗分析抗体的样品中的分析物的免疫测定

    公开(公告)号：WO2008051762A2

    公开(公告)日：2008-05-02

    申请号：PCT/US2007081608

    申请日：2007-10-17

    Applicant: ABBOTT LAB ,  MATTINGLY PHILLIP G ,  ADAMCZYK MACIEJ ,  BRASHEAR ROY JEFFREY

    Inventor： MATTINGLY PHILLIP G ,  ADAMCZYK MACIEJ ,  BRASHEAR ROY JEFFREY

    CPC classification number: G01N33/54393 ,  G01N33/54326 ,  G01N2800/24

    Abstract: The invention provides among other things an assay method that compensates for the presence of endogenous antibodies, e.g., autoantibodies, which might otherwise compromise the measurement of an analyte in a biological sample. In one embodiment, this method entails the use of a two labeled entities: a labeled detection agent and a labeled species-specific antibody, wherein the labeled species-specific antibody is specific for the species from which the biological sample was obtained. Sample analyte is bound by the detection agent and any anti-analyte autoantibodies present in the sample. Analyte bound by autoantibodies is detected via the species-specific antibody, optionally labeled.

    Abstract translation: 本发明提供补偿内源性抗体（例如自身抗体）的存在的测定方法，否则可能会损害生物样品中分析物的测量。 在一个实施方案中，该方法需要使用两个标记的实体：标记的检测试剂和标记物种特异性抗体，其中标记物种特异性抗体对于获得生物样品的物种是特异性的。 样品分析物被检测剂和样品中存在的任何抗分析物自身抗体结合。 通过物种特异性抗体检测由自身抗体结合的分析物，任选地标记。

    ASSAY FOR CARDIAC TROPONIN AUTOANTIBODIES
    3.
    发明申请
    ASSAY FOR CARDIAC TROPONIN AUTOANTIBODIES 审中-公开
    CARDIAC TROPONIN AUTOANTIBODIES的测定

    公开(公告)号：WO2008051761A3

    公开(公告)日：2008-11-13

    申请号：PCT/US2007081606

    申请日：2007-10-17

    Applicant: ABBOTT LAB ,  MATTINGLY PHILLIP G ,  ADAMCZYK MACIEJ ,  BRASHEAR ROY JEFFREY ,  DOSS ROBERT C

    Inventor： MATTINGLY PHILLIP G ,  ADAMCZYK MACIEJ ,  BRASHEAR ROY JEFFREY ,  DOSS ROBERT C

    IPC: G01N33/53

    CPC classification number: G01N33/6854 ,  G01N33/54326 ,  G01N33/564 ,  G01N2800/324 ,  G01N2800/325 ,  Y10T436/10 ,  Y10T436/101666 ,  Y10T436/25125

    Abstract: The invention provides among other things methods and kits based on assaying for cardiac troponin autoantibodies, either in conjunction with an assay for cardiac troponin and/or as an independent indicator of cardiac pathology, such as myocarditis, cardiomyopathy, and/or ischemic heart disease. Assay methods of the invention can be employed among other things to identify cardiac pathology, or risk thereof, in subjects who have an autoimmune disease or who are related to an individual with an autoimmune disease. In particular embodiments, the invention also provides a method of determining whether a subject having, or at risk for, a cardiac pathology is a candidate for immunosuppressive therapy or immunoabsorption therapy. The invention also provides kits and kit components that are useful for performing the methods of the invention.

    Abstract translation: 本发明还提供了基于心肌肌钙蛋白自身抗体测定的方法和试剂盒，其与心肌肌钙蛋白的测定和/或作为心脏病理学的独立指标，例如心肌炎，心肌病和/或缺血性心脏病。 本发明的测定方法可以用于鉴别患有自身免疫疾病或与具有自身免疫疾病的个体相关的受试者的心脏病理学或其风险。 在具体实施方案中，本发明还提供了确定具有或具有心脏病理危险的受试者是免疫抑制治疗或免疫吸收治疗的候选者的方法。 本发明还提供了可用于实施本发明方法的试剂盒和试剂盒组分。

    METHOD AND KIT FOR ASSESSING THE SUITABILITY OF ERYTHROCYTES FOR TRANSFUSION
    4.
    发明申请
    METHOD AND KIT FOR ASSESSING THE SUITABILITY OF ERYTHROCYTES FOR TRANSFUSION 审中-公开
    用于评估输血红细胞适宜性的方法和试剂盒

    公开(公告)号：WO2009131963A3

    公开(公告)日：2009-12-17

    申请号：PCT/US2009041182

    申请日：2009-04-21

    Applicant: ABBOTT LAB ,  ADAMCZYK MACIEJ B ,  BRASHEAR ROY JEFFREY ,  MATTINGLY PHILLIP G

    Inventor： ADAMCZYK MACIEJ B ,  BRASHEAR ROY JEFFREY ,  MATTINGLY PHILLIP G

    IPC: G01N33/50

    CPC classification number: G01N33/5064 ,  C12Q1/26

    Abstract: A method of assessing whether or not erythrocytes are suitable for transfusion into a recipient comprising (i) assaying a sample of erythrocytes for free choline, and (ii) comparing the level of free choline in the sample with the level of free choline deemed suitable for transfusion therapies; and a kit for use in such a method comprising at least one reagent for assaying the sample, instructions for conducting the assaying of the sample, and guidelines for assessing the suitability of the erythrocytes for transfusion.

    Abstract translation: 一种评估红细胞是否适于输注到接受者体内的方法，包括（i）分析红细胞样品中的游离胆碱，和（ii）比较样品中游离胆碱的水平和认为适合于游离胆碱水平的游离胆碱 输血疗法; 以及用于这种方法的试剂盒，其包含至少一种用于测定样品的试剂，用于进行样品测定的说明以及用于评估红细​​胞对于输血的适用性的指导。

    CARDIOVASCULAR AUTOIMMUNE DISEASE PANEL AND METHODS OF USING SAME
    5.
    发明申请
    CARDIOVASCULAR AUTOIMMUNE DISEASE PANEL AND METHODS OF USING SAME 审中-公开
    心血管自动免疫疾病小组及其使用方法

    公开(公告)号：WO2008080030A2

    公开(公告)日：2008-07-03

    申请号：PCT/US2007088477

    申请日：2007-12-21

    Applicant: ABBOTT LAB ,  MATTINGLY PHILLIP G ,  ADAMCZYK MACIEJ B ,  BRASHEAR ROY JEFFREY ,  DOSS ROBERT C

    Inventor： MATTINGLY PHILLIP G ,  ADAMCZYK MACIEJ B ,  BRASHEAR ROY JEFFREY ,  DOSS ROBERT C

    IPC: G01N33/53

    CPC classification number: G01N33/564 ,  G01N2800/32

    Abstract: Provided herein among other things are diagnostic tests, methods of use, and kits for the assessment and management of cardiovascular autoimmune disease and risk of cardiovascular autoimmune disease. Assay methods of the invention can be employed among other things to identify cardiovascular autoimmune disease, or risk thereof, in subjects who have cardiovascular disease, an autoimmune disease, or who are related to an individual with an autoimmune disease. The method can be employed for testing of a subject that exhibits symptoms of cardiovascular disease, as well as of a subject that is apparently healthy and does not yet exhibit symptoms of cardiovascular disease, but may with time. In one embodiment, the invention also provides a method of determining whether a subject having, or at risk for, a cardiovascular disease is a candidate for immunosuppressive therapy or immunoabsorption therapy. The invention also provides kits and kit components that are useful for performing the methods of the invention.

    Abstract translation: 除此之外，本文提供了诊断测试，使用方法以及用于评估和管理心血管自身免疫疾病和心血管自身免疫疾病风险的试剂盒。 本发明的测定方法尤其可用于鉴定患有心血管疾病，自身免疫性疾病或与患有自身免疫性疾病的个体有关的个体的心血管自身免疫疾病或其风险。 该方法可用于测试表现出心血管疾病症状的受试者以及明显健康并且尚未表现出心血管疾病症状但可能随时间变化的受试者。 在一个实施方案中，本发明还提供了确定患有心血管疾病或处于心血管疾病风险中的受试者是否是用于免疫抑制疗法或免疫吸收疗法的候选者的方法。 本发明还提供对于实施本发明的方法有用的试剂盒和试剂盒组分。

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