公开(公告)号：JP2002000267A

公开(公告)日：2002-01-08

申请号：JP2001120859

申请日：2001-04-19

Applicant: ABBOTT LAB

Inventor： MEHTA SMRITI U ,  JOHNSON-PAEPKE JILL ,  GEORGE SHEELA M ,  DESAI SURESH M ,  MIMMS LARRY T ,  DEVARE SUSHIL G ,  TYNER JOAN D ,  GIBADLO MARY S

IPC: C12N5/10 ,  C07K16/10 ,  C12N5/20 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/576 ,  G01N33/577

Abstract: PROBLEM TO BE SOLVED: To provide an antibody specifically bonding generally to hepatitis C virus(HCV), more particularly, a panel of a new hybridoma cell strain secreting a monoclonal antibody against HCV protein 33C and the use of the monoclonal antibody. SOLUTION: The present invention relates to a monoclonal antibody specifically bonding to HCV protein 33C and free from bonding potency to HCV protein C-100 and a core and to a hybridoma producing the monoclonal antibody and selected from the group consisting of A.T.C.C. deposit No. HB10594, HB10589, HB10607 and HB10600. It also relates to a method for the use of the monoclonal antibody e.g. for the detection of hepatitis C virus HCV 33C protein in a specimen and an assay kit containing the antibody.

公开(公告)号：JP2002012600A

公开(公告)日：2002-01-15

申请号：JP2001120871

申请日：2001-04-19

Applicant: ABBOTT LAB

Inventor： MEHTA SMRITI U ,  JOHNSON-PAEPKE JILL ,  GEORGE SHEELA M ,  DESAI SURESH M ,  MIMMS LARRY T ,  DEVARE SUSHIL G ,  TYNER JOAN D ,  GIBADLO MARY S

IPC: C12N5/10 ,  C07K16/10 ,  C12N5/20 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/576 ,  G01N33/577

Abstract: PROBLEM TO BE SOLVED: To provide a highly specific and novel monoclonal antibody available for detecting a hepatitis C virus protein. SOLUTION: A monoclonal antibody not binding to hepatitis C virus C-100 protein and hepatitis C virus 33C protein and specifically binding to hepatitis C virus core protein, a hybridoma yielding the monoclonal antibody, a method for using the monoclonal antibody and an assay kit containing the antibody are provided.

公开(公告)号：WO2009086398A3

公开(公告)日：2009-11-19

申请号：PCT/US2008088199

申请日：2008-12-23

Applicant: ABBOTT LAB ,  BROPHY SUSAN E ,  HAWKSWORTH DAVID J ,  SHAH DINESH O ,  SIEGEL ROBERT W ,  TIEMAN BRYAN C ,  TU BAILIN ,  ZIEMANN ROBERT N ,  TYNER LOWELL

Inventor： BROPHY SUSAN E ,  HAWKSWORTH DAVID J ,  SHAH DINESH O ,  SIEGEL ROBERT W ,  TIEMAN BRYAN C ,  TU BAILIN ,  ZIEMANN ROBERT N ,  TYNER JOAN D

IPC: C07K16/20 ,  G01N33/569

CPC classification number: G01N33/56905 ,  C07K16/20 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/92 ,  G01N2333/44 ,  G01N2469/10 ,  G01N2469/20 ,  G01N2496/00

Abstract: The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.

Abstract translation: 本公开涉及使用所述试剂来检测克氏锥虫表位的试剂和方法。

公开(公告)号：WO02064615A3

公开(公告)日：2003-04-17

申请号：PCT/US0143179

申请日：2001-12-05

Applicant: ABBOTT LAB

Inventor： LOU SHENG C ,  HUNT JEFFREY C ,  KONRATH JOHN G ,  QIU XIAOXING ,  SCHEFFEL JAMES W ,  TYNER JOAN D

IPC: G01N33/569 ,  C07K14/16 ,  C07K16/10 ,  C12N5/10 ,  C12N5/20 ,  C12N15/02 ,  C12P21/08 ,  G01N33/577 ,  G01N33/68

CPC classification number: C07K16/1054 ,  C07K7/08 ,  C07K14/005 ,  C07K14/161 ,  C07K2317/34 ,  C12N2740/16211 ,  C12N2740/16222 ,  G01N33/56983 ,  G01N33/68

Abstract: The present invention relates to novel monoclonal antibodies which may be used in the detection of Human Immunodeficiency Virus (HIV). These antibodies exhibit an unusually high degree of sensitivity, a remarkably broad range of specificity, and bind to novel shared, non-cross-reactive epitopes. In particular, the monoclonal antibodies of the present invention may be utilized to detect HIV-1 antigen and HIV-2 core antigen in a patient sample.

Abstract translation: 本发明涉及可用于检测人类免疫缺陷病毒（HIV）的新型单克隆抗体。 这些抗体表现出非常高的灵敏度，非常宽的特异性范围，并且结合新的共享的非交叉反应性表位。 特别地，本发明的单克隆抗体可用于检测患者样品中的HIV-1抗原和HIV-2核心抗原。

公开(公告)号：WO2009155324A3

公开(公告)日：2010-02-18

申请号：PCT/US2009047623

申请日：2009-06-17

Applicant: ABBOTT LAB ,  BROPHY SUSAN E ,  CHI LIANLI ,  DATWYLER SAUL A ,  HAWKSWORTH DAVID J ,  LAIRD DON M ,  MANOJ SHARMILA ,  PINKUS MARY S ,  PUCCI DOMINICK L ,  RAMSAY CAROL S ,  SOGIN DAVID C ,  TU BAILIN ,  TYNER JOAN D ,  YU ZHIGUANG ,  ZIEMANN ROBERT N

Inventor： BROPHY SUSAN E ,  CHI LIANLI ,  DATWYLER SAUL A ,  HAWKSWORTH DAVID J ,  LAIRD DON M ,  MANOJ SHARMILA ,  PINKUS MARY S ,  PUCCI DOMINICK L ,  RAMSAY CAROL S ,  SOGIN DAVID C ,  TU BAILIN ,  TYNER JOAN D ,  YU ZHIGUANG ,  ZIEMANN ROBERT N

IPC: C07K16/22 ,  C07K14/515 ,  C12N5/20 ,  C12N15/13

CPC classification number: C07K16/22 ,  C07K14/475 ,  C07K2317/92 ,  G01N33/74 ,  G01N2333/475

Abstract: The present disclosure relates to glycosylated and deglycosylated human PlGF-1, methods of using the glycosylated and deglycosylated human PlGF-1, antibodies that bind to human PlGF-1, methods of using the antibodies and human PlGF-1 immunoassays and kits.

Abstract translation: 本公开涉及糖基化和去糖基化的人PlGF-1，使用糖基化和去糖基化的人PlGF-1的方法，与人PlGF-1结合的抗体，使用抗体和人PlGF-1免疫测定和试剂盒的方法。

公开(公告)号：WO2009086411A2

公开(公告)日：2009-07-09

申请号：PCT/US2008088215

申请日：2008-12-23

Applicant: ABBOTT LAB ,  TYNER LOWELL J ,  BROPHY SUSAN E ,  BROWN WILLIAM E ,  KEIRANS WALT J

Inventor： BROPHY SUSAN E ,  BROWN WILLIAM E ,  KEIRANS WALT J ,  TYNER JOAN D

IPC: C07K16/00 ,  G01N33/48

CPC classification number: C07K16/00 ,  C07K2317/565 ,  C07K2317/567 ,  G01N33/74 ,  G01N2333/58 ,  G01N2800/32

Abstract: The present disclosure relates to isolated antibodies that do not bind to brain natriuretic peptide that can be used as a reagent to reduce heterophilic interference in an immunoassay.

Abstract translation: 本公开涉及不与脑钠素肽结合的分离的抗体，其可用作减少免疫测定中的嗜异性干扰的试剂。

公开(公告)号：EP2300825A4

公开(公告)日：2012-04-25

申请号：EP09767690

申请日：2009-06-17

Applicant: ABBOTT LAB

Inventor： DATWYLER SAUL ,  HAWKSWORTH DAVID J ,  LAIRD DON M ,  PUCCI DOMINICK L ,  SOGIN DAVID C ,  TYNER JOAN D ,  ZIEMANN ROBERT N ,  LESNIEWSKI RICHARD R ,  MCKEEGAN EVELYN MARY

IPC: G01N33/574 ,  C07K16/22 ,  G01N33/74

CPC classification number: G01N33/574 ,  G01N33/74 ,  G01N2800/50 ,  G01N2800/52

公开(公告)号：EP2158491A4

公开(公告)日：2011-11-23

申请号：EP08827464

申请日：2008-05-16

Applicant: ABBOTT LAB

Inventor： DATWYLER SAUL A ,  HAWKSWORTH DAVID J ,  HSU STEPHEN C ,  MATIAS MATTHEW S ,  PACENTI DAVID P ,  PINKUS MARY S ,  SHIH JESSIE W ,  TIEMAN BRYAN C ,  TYNER JOAN D ,  ZIEMANN ROBERT N

IPC: G01N33/573 ,  C12Q1/28 ,  G01N33/53

CPC classification number: G01N33/573 ,  C12Q1/28 ,  G01N2333/908 ,  G01N2800/32 ,  G01N2800/50 ,  G01N2800/56

公开(公告)号：EP0569537A4

公开(公告)日：1994-10-05

申请号：EP92906219

申请日：1992-01-30

Applicant: ABBOTT LAB

Inventor： GIBADLO MARY S ,  TYNER JOAN D ,  MIMMS LARRY T ,  VALLARI DAVID S

IPC: C12N5/10 ,  A61K39/00 ,  C07K14/18 ,  C07K16/10 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/576 ,  G01N33/577

CPC classification number: C07K14/005 ,  A61K39/00 ,  C07K16/109 ,  C12N2770/24222

公开(公告)号：WO2009052400A1

公开(公告)日：2009-04-23

申请号：PCT/US2008080340

申请日：2008-10-17

Applicant: ABBOTT LAB ,  BIRKENMEYER LARRY G ,  DESAI SURESH M ,  HAWKSWORTH DAVID J ,  OLEJNICZAK EDWARD T ,  RUAN QIAOQIAO ,  SIEGEL ROBERT W ,  TESTIN SERGE Y ,  TIEMAN BRYAN C ,  TU BAILIN ,  TYNER JOAN D ,  ZIEMANN ROBERT N

Inventor： BIRKENMEYER LARRY G ,  DESAI SURESH M ,  HAWKSWORTH DAVID J ,  OLEJNICZAK EDWARD T ,  RUAN QIAOQIAO ,  SIEGEL ROBERT W ,  TESTIN SERGE Y ,  TIEMAN BRYAN C ,  TU BAILIN ,  TYNER JOAN D ,  ZIEMANN ROBERT N

IPC: C07K16/18

CPC classification number: C07K14/47 ,  C07K2317/56 ,  C07K2317/92 ,  Y10T436/105831

Abstract: The present invention relates to antibodies specific for glycosylated mammalian NGAL, and to methods of making and using such antibodies.

Abstract translation: 本发明涉及糖基化哺乳动物NGAL的特异性抗体，以及制备和使用这种抗体的方法。