公开(公告)号：AU8430775A

公开(公告)日：1977-03-03

申请号：AU8430775

申请日：1975-08-27

Applicant: ABBOTT LAB

Inventor： OSLAPAS RAYMOND ,  HERRIN THOMAS RAYMOND

IPC: C07J19/00 ,  C07J41/00 ,  G01N33/94 ,  G01N33/16 ,  G01N23/00

Abstract: A competitive radioimmunoassay for the measurement of digoxin in a serum sample in which the non-radioactive digoxin competes with a constant amount of a radioactively labeled digoxin tyramine analog comprising 3-O-(4-Hydroxyphenethylcarbamoyl) digoxigenin for binding cites on a limited amount of digoxin antibody. The percentage of the radioactively labeled digoxin which is bound to the antibody is inversely proportional to the concentration of digoxin in the serum sample. The concentration of digoxin in the serum is determined by the comparison with standards containing measured amounts of unlabeled digoxin.

公开(公告)号：CA1036592A

公开(公告)日：1978-08-15

申请号：CA234197

申请日：1975-08-26

Applicant: ABBOTT LAB

Inventor： OSLAPAS RAYMOND ,  HERRIN THOMAS R

IPC: C07J19/00 ,  C07J41/00 ,  G01N33/94

Abstract: A competitive radioimmunoassay for the measurement of digoxin in a serum sample in which the nonradioactive digoxin competes with a constant amount of a radioactively labeled digoxin tyramine analog comprising 3-O-(4-hydroxy-phenethylcarbomoyl) digoxigenin for binding cites on a limited amount of digoxin antibody. The percentage of the radioactively labeled digoxin which is bound to the antibody is inversely proportional to the concentration of digoxin in the serum sample. The concentration of digoxin in the serum is determined by the comparison with standards containing measured amounts of unlabeled digoxin.

公开(公告)号：DE2539242A1

公开(公告)日：1976-04-01

申请号：DE2539242

申请日：1975-09-03

Applicant: ABBOTT LAB

Inventor： OSLAPAS RAYMOND ,  HERRIN THOMAS RAYMOND

IPC: C07J19/00 ,  C07J41/00 ,  G01N33/94 ,  G01N33/16

Abstract: A competitive radioimmunoassay for the measurement of digoxin in a serum sample in which the non-radioactive digoxin competes with a constant amount of a radioactively labeled digoxin tyramine analog comprising 3-O-(4-Hydroxyphenethylcarbamoyl) digoxigenin for binding cites on a limited amount of digoxin antibody. The percentage of the radioactively labeled digoxin which is bound to the antibody is inversely proportional to the concentration of digoxin in the serum sample. The concentration of digoxin in the serum is determined by the comparison with standards containing measured amounts of unlabeled digoxin.