中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

15 records (took 0.02 seconds)

    2.
    发明专利
    未知

    公开(公告)号：DK522884A

    公开(公告)日：1985-05-05

    申请号：DK522884

    申请日：1984-11-02

    Applicant: ABBOTT LAB

    Inventor： FLENTGE CHARLES ARTHUR ,  HERRIN THOMAS RAYMOND

    IPC: C07F9/40 ,  C07F9/553 ,  C07F9/6512 ,  C07F

    Abstract: Phenobarbital and carbamazepine conjugates for use as enzyme inhibitors having the formula: wherein R2 is selected from the group consisting of and wherein Z is a biologically compatible counter ion, n and m are each independently an integer from 2 to 6, and R and R1, are each lower alkyl.

    3.
    发明专利
    未知

    公开(公告)号：DE2539242A1

    公开(公告)日：1976-04-01

    申请号：DE2539242

    申请日：1975-09-03

    Applicant: ABBOTT LAB

    Inventor： OSLAPAS RAYMOND ,  HERRIN THOMAS RAYMOND

    IPC: C07J19/00 ,  C07J41/00 ,  G01N33/94 ,  G01N33/16

    Abstract: A competitive radioimmunoassay for the measurement of digoxin in a serum sample in which the non-radioactive digoxin competes with a constant amount of a radioactively labeled digoxin tyramine analog comprising 3-O-(4-Hydroxyphenethylcarbamoyl) digoxigenin for binding cites on a limited amount of digoxin antibody. The percentage of the radioactively labeled digoxin which is bound to the antibody is inversely proportional to the concentration of digoxin in the serum sample. The concentration of digoxin in the serum is determined by the comparison with standards containing measured amounts of unlabeled digoxin.

    5.
    发明专利
    未知

    公开(公告)号：DK522884D0

    公开(公告)日：1984-11-02

    申请号：DK522884

    申请日：1984-11-02

    Applicant: ABBOTT LAB

    Inventor： FLENTGE CHARLES ARTHUR ,  HERRIN THOMAS RAYMOND

    IPC: C07F9/40 ,  C07F9/553 ,  C07F9/6512 ,  C07F

    Abstract: Phenobarbital and carbamazepine conjugates for use as enzyme inhibitors having the formula: wherein R2 is selected from the group consisting of and wherein Z is a biologically compatible counter ion, n and m are each independently an integer from 2 to 6, and R and R1, are each lower alkyl.

    6.
    发明专利
    未知

    公开(公告)号：DE3003959A1

    公开(公告)日：1980-08-14

    申请号：DE3003959

    申请日：1980-02-04

    Applicant: ABBOTT LAB

    Inventor： VOSS HOUSTON FREDERICK ,  PLATTNER JACOB ,  HERRIN THOMAS RAYMOND

    IPC: C07F9/40 ,  C12Q1/46 ,  G01N33/532 ,  G01N33/542 ,  C07F9/201 ,  G01N33/16 ,  C07F9/65

    Abstract: The present invention encompasses a method for determining ligands in test samples comprising intermixing with the test sample a ligand analog-irreversible enzyme inhibitor conjugate and a binding protein bindable to the ligand and the ligand analog-irreversible enzyme inhibitor conjugate and wherein the amount of ligand analog-irreversible enzyme inhibitor conjugate bound by the binding protein is related to the amount of ligand in the test sample, said binding protein inactivating the irreversible enzyme inhibitor when bound to the ligand analog portion of the conjugate; intermixing an enzyme which is irreversibly inhibited by the ligand analog-irreversible enzyme inhibitor conjugate unbound by the binding protein; and intermixing substrate to the enzyme and monitoring the enzyme substrate reaction. The invention also includes ligand analog-irreversible enzyme inhibitor conjugates useful as reagents in practicing the method. Methods and reagents of the present are particularly useful in determining drugs, hormones, and the like in biological fluids.

    8.
    发明专利
    未知

    公开(公告)号：IT1130254B

    公开(公告)日：1986-06-11

    申请号：IT1967580

    申请日：1980-02-04

    Applicant: ABBOTT LAB

    Inventor： VOSS HOUSTON FREDERICK ,  PLATTNER JACOB ,  HERRIN THOMAS RAYMOND

    IPC: C07F9/40 ,  C12Q1/46 ,  G01N33/532 ,  G01N33/542 ,  G01N

    Abstract: The present invention encompasses a method for determining ligands in test samples comprising intermixing with the test sample a ligand analog-irreversible enzyme inhibitor conjugate and a binding protein bindable to the ligand and the ligand analog-irreversible enzyme inhibitor conjugate and wherein the amount of ligand analog-irreversible enzyme inhibitor conjugate bound by the binding protein is related to the amount of ligand in the test sample, said binding protein inactivating the irreversible enzyme inhibitor when bound to the ligand analog portion of the conjugate; intermixing an enzyme which is irreversibly inhibited by the ligand analog-irreversible enzyme inhibitor conjugate unbound by the binding protein; and intermixing substrate to the enzyme and monitoring the enzyme substrate reaction. The invention also includes ligand analog-irreversible enzyme inhibitor conjugates useful as reagents in practicing the method. Methods and reagents of the present are particularly useful in determining drugs, hormones, and the like in biological fluids.

    LIGAND ANALOGUE - IRRIVERSIBLE ENZYME INHIBITOR CONJUGATES
    10.
    发明专利
    LIGAND ANALOGUE - IRRIVERSIBLE ENZYME INHIBITOR CONJUGATES 未知

    公开(公告)号：AU528592B2

    公开(公告)日：1983-05-05

    申请号：AU5476380

    申请日：1980-01-21

    Applicant: ABBOTT LAB

    Inventor： VOSS HOUSTON FREDERICK ,  PLATTNER JACOB ,  HERRIN THOMAS RAYMOND

    IPC: C07F9/40 ,  C12Q1/46 ,  G01N33/532 ,  G01N33/542 ,  C07F9/65 ,  C07G17/00 ,  C07H15/22 ,  C07H23/00 ,  C07J41/00 ,  C07J43/00 ,  C12Q1/00 ,  G01N33/54

    Abstract: The present invention encompasses a method for determining ligands in test samples comprising intermixing with the test sample a ligand analog-irreversible enzyme inhibitor conjugate and a binding protein bindable to the ligand and the ligand analog-irreversible enzyme inhibitor conjugate and wherein the amount of ligand analog-irreversible enzyme inhibitor conjugate bound by the binding protein is related to the amount of ligand in the test sample, said binding protein inactivating the irreversible enzyme inhibitor when bound to the ligand analog portion of the conjugate; intermixing an enzyme which is irreversibly inhibited by the ligand analog-irreversible enzyme inhibitor conjugate unbound by the binding protein; and intermixing substrate to the enzyme and monitoring the enzyme substrate reaction. The invention also includes ligand analog-irreversible enzyme inhibitor conjugates useful as reagents in practicing the method. Methods and reagents of the present are particularly useful in determining drugs, hormones, and the like in biological fluids.

Patent Agency Ranking