公开(公告)号：US3903077A

公开(公告)日：1975-09-02

申请号：US34844073

申请日：1973-04-05

Applicant: ABBOTT LAB

Inventor： JONES PETER HADLEY ,  OURS CARROLL WAYNE ,  ROTEMAN ROBERT

IPC: C07D295/14 ,  C07C237/08 ,  C07C237/20 ,  C07D207/16 ,  C07D207/46 ,  C07D209/20 ,  C07D233/64 ,  C07D295/15 ,  C07D205/04

CPC classification number: C07D295/15 ,  C07D207/46

Abstract: An improved process for synthesizing amino acid amides of dopamine comprising reacting an active ester of an appropriate Ncarbobenzyloxy amino acid directly with a dopamine salt. The amino acid amides of dopamine are useful as renal vasodilators and antihypertensive agents.

Abstract translation: 一种合成多巴胺氨基酰胺的改进方法，包括使适当的N-苄氧羰基氨基酸的活性酯与多巴胺盐反应。 多巴胺的氨基酰胺可用作肾血管扩张剂和抗高血压药。

公开(公告)号：US3910988A

公开(公告)日：1975-10-07

申请号：US40890173

申请日：1973-10-23

Applicant: ABBOTT LAB

Inventor： JONES PETER HADLEY ,  KYNCL JAROSLAV ,  OURS CARROLL WAYNE ,  SOMANI PITAMBAR

IPC: A61K31/195 ,  A01N37/44 ,  A61K31/198 ,  A61K31/22 ,  A61P9/08 ,  C07C237/08 ,  C07C103/50

CPC classification number: A01N37/44 ,  Y10S514/929

Abstract: Covers the esters of gamma -glutamyl amide of dopamine selected from the group consisting of

where R is a C1-C20 alkyl radical, and a pharmaceutically acceptable acid addition salt thereof. Also covers the use of said esters of gamma -glutamyl amide of dopamine to increase renal blood flow by administering said amide to warm-blooded mammals by clinically acceptable routes of administration such as oral, parenteral, rectal, etc.

Abstract translation: 包括选自-CH 2 -CH 2 -NH 2 |平行C-CH 2 -CH 2 -CH-C-OR PARALLEL | ONH 2的多巴胺的γ-谷氨酰胺的酯，其中R是C 1 -C 20烷基， 其药学上可接受的酸加成盐。 还涵盖使用所述多巴胺的γ-谷氨酰胺的酯通过临床上可接受的给药途径（例如口服，胃肠外，直肠等）将所述酰胺施用于温血哺乳动物来增加肾血流量。

公开(公告)号：US3903147A

公开(公告)日：1975-09-02

申请号：US40890273

申请日：1973-10-23

Applicant: ABBOTT LAB

Inventor： KYNCL JAROSLAV ,  RILEY KATHLEEN ,  MARTIN YVONNE CONNOLLY ,  OURS CARROLL WAYNE

IPC: C07C237/00 ,  C07C103/50

CPC classification number: C07C237/00

Abstract: Covers a gamma -glutamyl amide of dopamine selected from the group consisting of

and a pharmaceutically acceptable acid addition salt thereof. Also covers the use of said gamma -glutamyl amide to increase renal blood flow by administering said amide to warm-blooded mammals.

Abstract translation: 覆盖选自HO | HO-CH 2 -CH 2 -NH 2 | PARALLEL C-CH 2 -CH 2 -CH-C-OH平行| ONH 2的多巴胺的γ-谷氨酰胺及其药学上可接受的酸加成盐。 还涵盖了通过将所述酰胺施用于温血哺乳动物来增加所述γ-谷氨酰胺以增加肾血流量的用途。

公开(公告)号：CH595325A5

公开(公告)日：1978-02-15

申请号：CH1410874

申请日：1974-10-22

Applicant: ABBOTT LAB

Inventor： JONES PETER HADLEY ,  KYNCL JAROSLAV ,  OURS CARROLL WAYNE ,  SOMANI PITAMBAR

IPC: A61K31/195 ,  A01N37/44 ,  A61K31/198 ,  A61K31/22 ,  A61P9/08 ,  C07C237/08 ,  C07C103/38 ,  C07C103/50

Abstract: Covers the esters of gamma -glutamyl amide of dopamine selected from the group consisting of -CH2-CH2-NHO ¦ PARALLEL C-CH2-CH2-CH-C-OR PARALLEL ¦ ONH2 where R is a C1-C20 alkyl radical, and a pharmaceutically acceptable acid addition salt thereof. Also covers the use of said esters of gamma -glutamyl amide of dopamine to increase renal blood flow by administering said amide to warm-blooded mammals by clinically acceptable routes of administration such as oral, parenteral, rectal, etc.

公开(公告)号：NO741143L

公开(公告)日：1974-10-08

申请号：NO741143

申请日：1974-03-29

Applicant: ABBOTT LAB

Inventor： OURS CARROLL WAYNE ,  JONES PETER HADLEY ,  ROTEMAN ROBERT

IPC: C07C237/08 ,  C07D295/14 ,  C07C237/20 ,  C07D207/16 ,  C07D207/46 ,  C07D209/20 ,  C07D233/64 ,  C07D295/15

公开(公告)号：FI59987C

公开(公告)日：1981-11-10

申请号：FI102674

申请日：1974-04-03

Applicant: ABBOTT LAB

Inventor： JONES PETER HADLEY ,  OURS CARROLL WAYNE ,  ROTEMAN ROBERT

IPC: C07D295/14 ,  C07C237/08 ,  C07C237/20 ,  C07D207/16 ,  C07D207/46 ,  C07D209/20 ,  C07D233/64 ,  C07D295/15 ,  C07C103/50

Abstract: An improved process for synthesizing amino acid amides of dopamine comprising reacting an active ester of an appropriate N-carbobenzyloxy amino acid directly with a dopamine salt. The amino acid amides of dopamine are useful as renal vasodilators and antihypertensive agents.

公开(公告)号：FI59987B

公开(公告)日：1981-07-31

申请号：FI102674

申请日：1974-04-03

Applicant: ABBOTT LAB

Inventor： JONES PETER HADLEY ,  OURS CARROLL WAYNE ,  ROTEMAN ROBERT

IPC: C07D295/14 ,  C07C237/08 ,  C07C237/20 ,  C07D207/16 ,  C07D207/46 ,  C07D209/20 ,  C07D233/64 ,  C07D295/15 ,  C07C103/50

Abstract: An improved process for synthesizing amino acid amides of dopamine comprising reacting an active ester of an appropriate N-carbobenzyloxy amino acid directly with a dopamine salt. The amino acid amides of dopamine are useful as renal vasodilators and antihypertensive agents.

公开(公告)号：IT8025204D0

公开(公告)日：1980-10-08

申请号：IT2520480

申请日：1980-10-08

Applicant: ABBOTT LAB

Inventor： OURS CARROLL WAYNE ,  LEE CHEUK MAN

IPC: A61K31/135 ,  A61K31/16 ,  A61K31/165 ,  A61P7/10 ,  C07C59/90 ,  C07C67/00 ,  C07C213/00 ,  C07C225/16 ,  C07C231/00 ,  C07C235/20 ,  C07C313/00 ,  C07C323/32 ,  C07D295/112 ,  C07C

公开(公告)号：NO142523C

公开(公告)日：1980-09-03

申请号：NO741143

申请日：1974-03-29

Applicant: ABBOTT LAB

Inventor： JONES PETER HADLEY ,  OURS CARROLL WAYNE ,  ROTEMAN ROBERT

IPC: C07D295/14 ,  C07C237/08 ,  C07C237/20 ,  C07D207/16 ,  C07D207/46 ,  C07D209/20 ,  C07D233/64 ,  C07D295/15 ,  C07C103/50

Abstract: An improved process for synthesizing amino acid amides of dopamine comprising reacting an active ester of an appropriate N-carbobenzyloxy amino acid directly with a dopamine salt. The amino acid amides of dopamine are useful as renal vasodilators and antihypertensive agents.

公开(公告)号：DE2450161A1

公开(公告)日：1975-04-24

申请号：DE2450161

申请日：1974-10-22

Applicant: ABBOTT LAB

Inventor： JONES PETER HADLEY ,  KYNCL JAROSLAV ,  OURS CARROLL WAYNE ,  SOMANI PITAMBAR

IPC: A61K31/195 ,  A01N37/44 ,  A61K31/198 ,  A61K31/22 ,  A61P9/08 ,  C07C237/08 ,  C07C103/50

Abstract: Covers the esters of gamma -glutamyl amide of dopamine selected from the group consisting of -CH2-CH2-NHO ¦ PARALLEL C-CH2-CH2-CH-C-OR PARALLEL ¦ ONH2 where R is a C1-C20 alkyl radical, and a pharmaceutically acceptable acid addition salt thereof. Also covers the use of said esters of gamma -glutamyl amide of dopamine to increase renal blood flow by administering said amide to warm-blooded mammals by clinically acceptable routes of administration such as oral, parenteral, rectal, etc.