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公开(公告)号：JP2010075188A
公开(公告)日：2010-04-08
申请号：JP2009256176
申请日：2009-11-09
Applicant: Abbott Lab , アボット・ラボラトリーズAbbott Laboratories
Inventor： BILLING-MEDEL PATRICIA A , COHEN MAURICE , COLPITTS TRACEY L , FRIEDMAN PAULA N , GORDON JULIAN , GRANADOS EDWARD N , HODGES STEVEN C , KLASS MICHAEL R , KRATOCHVIL JON D , ROBERTS-RAPP LISA , RUSSELL JOHN C , STROUPE STEVEN D
IPC: C12N15/09 , G01N33/53 , A61K38/00 , A61K39/395 , A61P35/00 , C07K14/47 , C07K16/18 , C07K16/30 , C12M1/26 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12Q1/68 , G01N33/574
CPC classification number: C07K16/3015 , A61K38/00 , C07K14/47 , C12Q1/6886 , C12Q2600/136
Abstract: PROBLEM TO BE SOLVED: To provide a method useful for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining predisposition to diseases or conditions of the breast such as breast cancer. SOLUTION: A set of contiguous or partially overlapping RNA sequences, and polypeptides encoded thereby, designated as BS106 and transcribed from breast tissue is provided. The sequences are useful for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases or conditions of the breast such as the breast cancer. Furthermore, there is provided an antibody which specifically binds to BS106-encoded polypeptide or protein, and an agonist or inhibitor which prevents action of the tissue-specific BS106 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases. COPYRIGHT: (C)2010,JPO&INPIT
Abstract translation: 要解决的问题：提供一种用于检测，诊断，分期，监测，预后，预防或治疗或确定乳腺疾病或病症倾向的方法，如乳腺癌。 提供了一组连续或部分重叠的RNA序列及其编码的多肽，称为BS106并从乳腺组织转录。 该序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对乳腺疾病或病症（例如乳腺癌）的倾向。 此外，提供了特异性结合BS106编码的多肽或蛋白质的抗体，以及防止组织特异性BS106多肽的作用的激动剂或抑制剂，该分子可用于治疗乳腺疾病，肿瘤或转移瘤。 版权所有（C）2010，JPO＆INPIT
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公开(公告)号：WO0165262A3
公开(公告)日：2002-04-11
申请号：PCT/US0106516
申请日：2001-02-28
Applicant: ABBOTT LAB
Inventor： BILLING-MEDEL PATRICIA A , COHEN MAURICE , COLPITTS TRACEY L , FRIEDMAN PAULA N , GORDON JULIAN , GRANADOS EDWARD N , HODGES STEVEN C , KLASS MICHAEL R , KRATOCHVIL JON D , ROBERTS-RAPP LISA , RUSSELL JOHN C , STROUPE STEVEN D
IPC: G01N33/53 , C07K14/47 , C07K16/18 , C07K19/00 , C12N5/10 , C12N15/09 , C12Q1/02 , G01N33/574 , C07K16/30
CPC classification number: G01N33/57415 , C07K14/4748
Abstract: Multimeric polypeptides antigens comprising polypeptides designated as BS106 and transcribed from breast tissue is described. These sequences are useful for the detecting, diagnosing, staging, monitoring prognosticating or determining the predisposition of an individual to diseases and conditions of the breast such as breast cancer. Also provided are antibodies which specifically bind to BS106-encoded polypeptide or protein.
Abstract translation: 描述了包含称为BS106并从乳腺组织转录的多肽的多聚体多肽抗原。 这些序列可用于检测，诊断，分期，监测预测或确定个体对乳腺疾病和状况（例如乳腺癌）的倾向。 还提供了特异性结合BS106编码的多肽或蛋白质的抗体。
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3.发明申请REAGENTS AND METHODS USEFUL FOR DETECTING DISEASES OF THE PROSTATE, BREAST AND OVARY 审中-公开用于检测前列腺，乳腺和卵巢疾病的试剂和方法
公开(公告)号：WO9914357A9
公开(公告)日：1999-07-08
申请号：PCT/US9819496
申请日：1998-09-18
Applicant: ABBOTT LAB
Inventor： BILLING-MEDEL PATRICIA A , COHEN MAURICE , COLPITTS TRACEY L , FRIEDMAN PAULA N , GORDON JULIAN , GRANADOS EDWARD N , HODGES STEVEN C , KLASS MICHAEL R , KRATOCHVIL JON D , MERCHANT BARBARA T , ROBERTS-RAPP LISA , RUSSELL JOHN C , STROUPE STEPHEN D
IPC: A61K38/00 , C07K14/705 , C07K16/30 , C12Q1/68 , A61K38/17 , C07K14/47 , C07K16/18 , C12N5/10 , G01N33/574
CPC classification number: C07K16/3015 , A61K38/00 , A61K2039/51 , C07K14/705 , C07K16/3069 , C12Q1/6886 , C12Q2600/136
Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PS214 and transcribed from prostate, breast, or ovary tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, breast, or ovary, such as prostate, breast, or ovarian cancer. Also provided are antibodies which specifically bind to PS214-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS214 polypeptide, which molecules are useful for the therapeutic treatment of prostate, breast, or ovary diseases, tumors or metastases.
Abstract translation: 描述了一组连续和部分重叠的cDNA序列和由此编码的多肽，命名为PS214并从前列腺，乳腺或卵巢组织转录。 这些序列可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对前列腺，乳腺或卵巢的疾病和状况的倾向，例如前列腺，乳腺， 或卵巢癌。 还提供了特异性结合PS214编码的多肽或蛋白质的抗体，以及预防组织特异性PS214多肽的作用的激动剂或抑制剂，该分子可用于前列腺，乳腺或卵巢疾病，肿瘤或转移的治疗性治疗 。
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公开(公告)号：WO0041516A3
公开(公告)日：2000-11-02
申请号：PCT/US0001309
申请日：2000-01-19
Applicant: ABBOTT LAB
Inventor： BILLING-MEDEL PATRICIA A , COHEN MAURICE , COLPITTS TRACEY L , FRIEDMAN PAULA N , GORDON JULIAN , GRANADOS EDWARD N , HODGES STEVEN C , KLASS MICHAEL R , KRATOCHVIL JON D , ROBERTS-RAPP LISA , RUSSELL JOHN C , SCHEFFEL CHRISTI P , STROUPE STEPHEN D
IPC: G01N33/53 , A61K31/711 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/574 , G01N33/58 , G01N37/00
CPC classification number: C07K14/47
Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BU101 and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to BU101-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BU101 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.
Abstract translation: 描述了一组连续和部分重叠的cDNA序列和由此编码的多肽，命名为BU101并从乳腺组织转录。 这些序列可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对乳腺疾病和病症如乳腺癌的倾向。 还提供了特异性结合BU101编码的多肽或蛋白质的抗体，以及预防组织特异性BU101多肽的作用的激动剂或抑制剂，该分子可用于治疗乳腺疾病，肿瘤或转移瘤。
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公开(公告)号：WO9931274A2
公开(公告)日：1999-06-24
申请号：PCT/US9826441
申请日：1998-12-11
Applicant: ABBOTT LAB
Inventor： BILLING-MEDEL PATRICIA A , COHEN MAURICE , COLPITTS TRACEY L , FRIEDMAN PAULA N , GORDON JULIAN , GRANADOS EDWARD N , HODGES STEVEN C , KLASS MICHAEL R , KRATOCHVIL JON D , ROBERTS-RAPP LISA , RUSSELL JOHN C , STROUPE STEPHEN D
IPC: C07K14/47 , C07K16/18 , C12Q1/68 , C12N5/10 , G01N33/574
Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PA153 and transcribed from pancreatic tissue, are described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the pancreas, such as pancreatic cancer. Also provided are antibodies which specifically bind to PA153-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PA153 polypeptide, which molecules are useful for the therapeutic treatment of pancreatic diseases, tumors or metastases.
Abstract translation: 描述了一组连续和部分重叠的cDNA序列和由其编码的多肽，命名为PA153并从胰腺组织转录。 这些序列可用于检测，诊断，分期，监测，预测，体内成像，预防或治疗或确定个体对胰腺疾病和病症（例如胰腺癌）的倾向性。 还提供了特异性结合PA153编码的多肽或蛋白质的抗体，以及阻止组织特异性PA153多肽作用的激动剂或抑制剂，所述分子可用于治疗性治疗胰腺疾病，肿瘤或转移瘤。
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Patent Agency Ranking6.发明申请REAGENTS AND METHODS USEFUL FOR DETECTING DISEASES OF THE PROSTATE, BREAST AND OVARY 审中-公开用于检测前列腺，乳房和卵巢疾病的试剂和方法
公开(公告)号：WO9914357A3
公开(公告)日：1999-05-27
申请号：PCT/US9819496
申请日：1998-09-18
Applicant: ABBOTT LAB
Inventor： BILLING-MEDEL PATRICIA A , COHEN MAURICE , COLPITTS TRACEY L , FRIEDMAN PAULA N , GORDON JULIAN , GRANADOS EDWARD N , HODGES STEVEN C , KLASS MICHAEL R , KRATOCHVIL JON D , MERCHANT BARBARA T , ROBERTS-RAPP LISA , RUSSELL JOHN C , STROUPE STEPHEN D
IPC: A61K38/00 , C07K14/705 , C07K16/30 , C12Q1/68 , A61K38/17 , C07K14/47 , C07K16/18 , C12N5/10 , G01N33/574
CPC classification number: C07K16/3015 , A61K38/00 , A61K2039/51 , C07K14/705 , C07K16/3069 , C12Q1/6886 , C12Q2600/136
Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PS214 and transcribed from prostate, breast, or ovary tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, breast, or ovary, such as prostate, breast, or ovarian cancer. Also provided are antibodies which specifically bind to PS214-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS214 polypeptide, which molecules are useful for the therapeutic treatment of prostate, breast, or ovary diseases, tumors or metastases.
Abstract translation: 描述了一组连续和部分重叠的cDNA序列和由其编码的多肽，命名为PS214并从前列腺癌，乳腺癌或卵巢组织转录。 这些序列可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对前列腺癌，乳腺癌或卵巢疾病和病症的倾向，如前列腺癌，乳腺癌， 或卵巢癌。 还提供了特异性结合PS214编码的多肽或蛋白质的抗体，以及阻止组织特异性PS214多肽作用的激动剂或抑制剂，所述分子可用于治疗性治疗前列腺癌，乳腺癌或卵巢疾病，肿瘤或转移瘤 。
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7.发明申请REAGENTS AND METHODS USEFUL FOR DETECTING DISEASE OF THE URINARY TRACT 审中-公开用于检测URINARY TRACT疾病的试剂和方法
公开(公告)号：WO9851824A9
公开(公告)日：1999-04-01
申请号：PCT/US9809972
申请日：1998-05-15
Applicant: ABBOTT LAB
Inventor： BILLING-MEDEL PATRICIA A , COHEN MAURICE , COLPITTS TRACEY L , FRIEDMAN PAULA N , GRANADOS EDWARD N , HODGES STEVEN C , KLASS MICHAEL R , KRATOCHVIL JON D , ROBERTS-RAPP LISA , RUSSELL JOHN C , STROUPE STEPHEN D
CPC classification number: C07K16/18 , C07K14/47 , C12Q1/6886 , C12Q2600/136 , G01N33/6893 , G01N2800/348
Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as UT116 and transcribed from urinary tract tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the urinary tract, such as urinary tract cancer. Also provided are antibodies which specifically bind to UT116-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific UT116 polypeptide, which molecules are useful for the therapeutic treatment of urinary tract diseases, tumors or metastases.
Abstract translation: 描述了一组连续和部分重叠的cDNA序列和由此编码的多肽，其被命名为UT116并从尿道组织转录。 这些序列可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对泌尿道疾病和病症如尿道癌的倾向。 还提供了特异性结合UT116编码的多肽或蛋白质的抗体，以及预防组织特异性UT116多肽的作用的激动剂或抑制剂，该分子可用于治疗尿路疾病，肿瘤或转移瘤。
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公开(公告)号：CA2232237C
公开(公告)日：2011-10-18
申请号：CA2232237
申请日：1997-08-19
Applicant: ABBOTT LAB
Inventor： BILLING-MEDEL PATRICIA A , COHEN MAURICE , COLPITTS TRACEY L , FRIEDMAN PAULA N , GORDON JULIAN , GRANADOS EDWARD N , HODGES STEVEN C , KLASS MICHAEL R , KRATOCHVIL JON D , ROBERTS-RAPP LISA , RUSSELL JOHN C , STROUPE STEPHEN D
IPC: C12N15/12 , G01N33/53 , A61K31/70 , A61K39/00 , A61K48/00 , C07H21/00 , C07K14/47 , C07K14/82 , C07K16/18 , C07K16/30 , C12N5/00 , C12N5/10 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/91 , G01N33/543 , G01N33/574
Abstract: A novel member of the uteroglobin family of proteins, designated as BU101, is described. BU101 is defined by a set of contiguous and partially overlapping RNA sequences transcribed from breast tissue, and polypeptides encoded thereby. A fully sequenced clone representing the longest continuous sequence of BU101 is also disclosed. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast such as breast cancer. Also provided are antibodies which specifically bind to BU101-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BU101 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.
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公开(公告)号：AT449171T
公开(公告)日：2009-12-15
申请号：AT97938467
申请日：1997-08-19
Applicant: ABBOTT LAB
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公开(公告)号：CA2292759A1
公开(公告)日：1998-12-10
申请号：CA2292759
申请日：1998-06-05
Applicant: ABBOTT LAB
Inventor： GORDON JULIAN , GRANADOS EDWARD N , HODGES STEVEN C , KLASS MICHAEL R , ROBERTS-RAPP LISA , KRATOCHVIL JON D , FRIEDMAN PAULA N , RUSSELL JOHN C , STROUPE STEPHEN D , YU HONG , BILLING-MEDEL PATRICIA A , COLPITTS TRACEY L , COHEN MAURICE
IPC: G01N33/53 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , G01N33/566 , G01N33/574 , C12N5/12
Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BL172 and transcribed from urinary tract tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the urinary tract, such as urinary tract cancer. Also provided are antibodies which specifically bind to BL172-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissuespecific BL172 polypeptide, which molecules are useful for the therapeutic treatment of urinary tract diseases, tumors or metastases.
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