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公开(公告)号：JP2010075188A
公开(公告)日：2010-04-08
申请号：JP2009256176
申请日：2009-11-09
Applicant: Abbott Lab , アボット・ラボラトリーズAbbott Laboratories
Inventor： BILLING-MEDEL PATRICIA A , COHEN MAURICE , COLPITTS TRACEY L , FRIEDMAN PAULA N , GORDON JULIAN , GRANADOS EDWARD N , HODGES STEVEN C , KLASS MICHAEL R , KRATOCHVIL JON D , ROBERTS-RAPP LISA , RUSSELL JOHN C , STROUPE STEVEN D
IPC: C12N15/09 , G01N33/53 , A61K38/00 , A61K39/395 , A61P35/00 , C07K14/47 , C07K16/18 , C07K16/30 , C12M1/26 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12Q1/68 , G01N33/574
CPC classification number: C07K16/3015 , A61K38/00 , C07K14/47 , C12Q1/6886 , C12Q2600/136
Abstract: PROBLEM TO BE SOLVED: To provide a method useful for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining predisposition to diseases or conditions of the breast such as breast cancer. SOLUTION: A set of contiguous or partially overlapping RNA sequences, and polypeptides encoded thereby, designated as BS106 and transcribed from breast tissue is provided. The sequences are useful for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases or conditions of the breast such as the breast cancer. Furthermore, there is provided an antibody which specifically binds to BS106-encoded polypeptide or protein, and an agonist or inhibitor which prevents action of the tissue-specific BS106 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases. COPYRIGHT: (C)2010,JPO&INPIT
Abstract translation: 要解决的问题：提供一种用于检测，诊断，分期，监测，预后，预防或治疗或确定乳腺疾病或病症倾向的方法，如乳腺癌。 提供了一组连续或部分重叠的RNA序列及其编码的多肽，称为BS106并从乳腺组织转录。 该序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对乳腺疾病或病症（例如乳腺癌）的倾向。 此外，提供了特异性结合BS106编码的多肽或蛋白质的抗体，以及防止组织特异性BS106多肽的作用的激动剂或抑制剂，该分子可用于治疗乳腺疾病，肿瘤或转移瘤。 版权所有（C）2010，JPO＆INPIT
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公开(公告)号：WO0165262A3
公开(公告)日：2002-04-11
申请号：PCT/US0106516
申请日：2001-02-28
Applicant: ABBOTT LAB
Inventor： BILLING-MEDEL PATRICIA A , COHEN MAURICE , COLPITTS TRACEY L , FRIEDMAN PAULA N , GORDON JULIAN , GRANADOS EDWARD N , HODGES STEVEN C , KLASS MICHAEL R , KRATOCHVIL JON D , ROBERTS-RAPP LISA , RUSSELL JOHN C , STROUPE STEVEN D
IPC: G01N33/53 , C07K14/47 , C07K16/18 , C07K19/00 , C12N5/10 , C12N15/09 , C12Q1/02 , G01N33/574 , C07K16/30
CPC classification number: G01N33/57415 , C07K14/4748
Abstract: Multimeric polypeptides antigens comprising polypeptides designated as BS106 and transcribed from breast tissue is described. These sequences are useful for the detecting, diagnosing, staging, monitoring prognosticating or determining the predisposition of an individual to diseases and conditions of the breast such as breast cancer. Also provided are antibodies which specifically bind to BS106-encoded polypeptide or protein.
Abstract translation: 描述了包含称为BS106并从乳腺组织转录的多肽的多聚体多肽抗原。 这些序列可用于检测，诊断，分期，监测预测或确定个体对乳腺疾病和状况（例如乳腺癌）的倾向。 还提供了特异性结合BS106编码的多肽或蛋白质的抗体。
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公开(公告)号：CA2269634A1
公开(公告)日：1998-05-07
申请号：CA2269634
申请日：1997-10-31
Applicant: ABBOTT LAB
Inventor： BILLING-MEDEL PATRICIA A , GRANADOS EDWARD N , HODGES STEVEN C , RUSSELL JOHN C , STROUPE STEVEN D , GORDON JULIAN , FRIEDMAN PAULA N , KRATOCHVIL JON D , KLASS MICHAEL R , COLPITTS TRACEY L , COHEN MAURICE , ROBERTS-RAPP LISA
IPC: G01N33/53 , A61K38/00 , A61K39/395 , A61P35/00 , C07K14/47 , C07K16/30 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/68 , C12N15/63 , A61K38/17 , G01N33/574 , G01N33/577
Abstract: A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as BS106 and transcribed from breast tissue is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast such as breast cancer. Also provided are antibodies which specifically bind to BS106-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS106 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.
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公开(公告)号：CA2399047C
公开(公告)日：2011-04-19
申请号：CA2399047
申请日：2001-02-28
Applicant: ABBOTT LAB
Inventor： BILLING-MEDEL PATRICIA A , COHEN MAURICE , COLPITTS TRACEY L , FRIEDMAN PAULA N , GORDON JULIAN , GRANADOS EDWARD N , HODGES STEVEN C , KLASS MICHAEL R , KRATOCHVIL JON D , ROBERTS-RAPP LISA , RUSSELL JOHN C , STROUPE STEVEN D
IPC: C12N15/12 , G01N33/53 , C07H21/00 , C07K14/47 , C07K16/18 , C07K16/30 , C07K19/00 , C12N5/10 , C12N15/09 , C12Q1/02 , G01N33/574
Abstract: Multimeric polypeptides antigens comprising polypeptides designated as BS106 and transcribed from breast tissue is described. These sequences are useful for the detecting, diagnosing, staging, monitoring prognosticating or determining the predisposition of an individual to diseases and conditions of the breast such as breast cancer. Also provided are antibodies which specifically bind to BS106-encoded polypeptide or protein.
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公开(公告)号：DE69737788D1
公开(公告)日：2007-07-19
申请号：DE69737788
申请日：1997-10-31
Applicant: ABBOTT LAB
Inventor： BILLING-MEDEL PATRICIA A , COHEN MAURICE , COLPITTS TRACEY L , FRIEDMAN PAULA N , GORDON JULIAN , GRANADOS EDWARD N , HODGES STEVEN C , KLASS MICHAEL R , KRATOCHVIL JON D , ROBERTS-RAPP LISA , RUSSELL JOHN C , STROUPE STEVEN D
IPC: C12N15/63 , G01N33/53 , A61K38/00 , A61K39/395 , A61P35/00 , C07K14/47 , C07K16/30 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/68 , G01N33/574 , G01N33/577
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Patent Agency Ranking
公开(公告)号：DE69737788T2
公开(公告)日：2008-03-13
申请号：DE69737788
申请日：1997-10-31
Applicant: ABBOTT LAB
Inventor： BILLING-MEDEL PATRICIA A , COHEN MAURICE , COLPITTS TRACEY L , FRIEDMAN PAULA N , GORDON JULIAN , GRANADOS EDWARD N , HODGES STEVEN C , KLASS MICHAEL R , KRATOCHVIL JON D , ROBERTS-RAPP LISA , RUSSELL JOHN C , STROUPE STEVEN D
IPC: C12N15/63 , G01N33/53 , A61K38/00 , A61K39/395 , A61P35/00 , C07K14/47 , C07K16/30 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/68 , G01N33/574 , G01N33/577
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公开(公告)号：CA2285039A1
公开(公告)日：1998-10-08
申请号：CA2285039
申请日：1998-03-31
Applicant: ABBOTT LAB
Inventor： RUSSELL JOHN C , STROUPE STEVEN D , HAYDEN MARK , GORDON JULIAN , KRATOCHVIL JON D , FRIEDMAN PAULA N , HODGES STEVEN C , BILLING-MEDEL PATRICIA A , COHEN MAURICE , KLASS MICHAEL R , COLPITTS TRACEY L , GRANADOS EDWARD N
IPC: G01N33/50 , A61K38/00 , A61K39/395 , A61P35/00 , C07K14/47 , C07K16/18 , C07K16/30 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C12N15/63 , A61K38/17 , G01N33/574 , G01N33/577
Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS141 and transcribed from GI tract tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the GI tract, such as GI tract cancer. Also provided are antibodies which specifically bind to CS141-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific CS141 polypeptide, which molecules are useful for the therapeutic treatment of GI tract diseases, tumors or metastases.
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公开(公告)号：CA2232237A1
公开(公告)日：1998-02-26
申请号：CA2232237
申请日：1997-08-19
Applicant: ABBOTT LAB
Inventor： GRANADOS EDWARD N , ROBERTS-RAPP LISA , HODGES STEVEN C , RUSSELL JOHN C , BILLING-MEDEL PATRICIA A , KLASS MICHAEL R , KRATOCHVIL JON D , STROUPE STEVEN D , FRIEDMAN PAULA N , COHEN MAURICE , COLPITTS TRACEY L , GORDON JULIAN
IPC: G01N33/53 , C07K14/47 , C07K14/82 , C07K16/30 , C12N5/00 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/91 , G01N33/574 , A61K31/70 , A61K39/00 , A61K48/00 , C07H21/00 , C07K16/18 , G01N33/543
Abstract: A novel member of the uteroglobin family of proteins, designated as BU101, is described. BU101 is defined by a set of contiguous and partially overlapping RNA sequences transcribed from breast tissue, and polypeptides encoded thereby. A fully sequenced clone representing the longest continuous sequence of BU101 is also disclosed. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast such as breast cancer. Also provided are antibodies which specifically bind to BU101-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BU101 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.
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公开(公告)号：DE69739653D1
公开(公告)日：2009-12-31
申请号：DE69739653
申请日：1997-08-19
Applicant: ABBOTT LAB
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公开(公告)号：CA2279551A1
公开(公告)日：1998-08-06
申请号：CA2279551
申请日：1998-01-30
Applicant: ABBOTT LAB
Inventor： ROBERTS-RAPP LISA , COHEN MAURICE , BILLING-MEDEL PATRICIA A , RUSSELL JOHN C , KLASS MICHAEL R , GORDON JULIAN , HODGES STEVEN C , GRANADOS EDWARD N , COLPITTS TRACEY L , FRIEDMAN PAULA N , STROUPE STEVEN D , KRATOCHVIL JON D , HAYDEN MARK
IPC: C12N15/09 , C07K14/47 , C07K16/30 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12Q1/68 , C12N15/63
Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as LU105 and transcribed from lung tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the lung, such as lung cancer. Also provided are antibodies which specifically bind to LU105encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific LU105 polypeptide, which molecules are useful for the therapeutic treatment of lung diseases, tumors or metastases.
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