公开(公告)号：CA2001318A1

公开(公告)日：1990-04-25

申请号：CA2001318

申请日：1989-10-24

Applicant: ABBOTT LAB

Inventor： NORBECK DANIEL W ,  ROSEN TERRY J ,  PARIZA RICHARD J ,  SOWIN THOMAS J ,  PLATTNER JACOB J ,  GARMAISE DAVID L ,  HANNICK STEVEN M

IPC: C07D251/18 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/4425 ,  A61K31/505 ,  A61K31/52 ,  A61K31/522 ,  A61P31/12 ,  C07C61/04 ,  C07C67/347 ,  C07C69/635 ,  C07C215/42 ,  C07C271/18 ,  C07C271/20 ,  C07C271/24 ,  C07C275/50 ,  C07C321/24 ,  C07D213/69 ,  C07D239/10 ,  C07D239/46 ,  C07D239/47 ,  C07D239/54 ,  C07D251/16 ,  C07D253/06 ,  C07D253/065 ,  C07D403/04 ,  C07D471/04 ,  C07D473/00 ,  C07D473/02 ,  C07D473/18 ,  C07D473/26 ,  C07D473/34 ,  C07D473/40 ,  C07D487/04 ,  C07F7/18 ,  C07F9/38 ,  C07F9/6561

Abstract: CARBOCYCLIC NUCLEOSIDE ANALOGS A compound of the formula: wherein A is a purin-9-yl group, a heterocyclic isostere of a purin-9-yl group, a pyrimidin-1-yl group or a heterocyclic isostere of a pyrimidin-1-yl group; E is hydrogen, -CH2OH or -OH; and G and D are independently selected from hydrogen, C1 to C10 alkyl, OH, -CH2OH, -CH2OR20 wherein R20 i8 C1 to C6 alkyl, -CH20C(O)R21 wherein R21 is C1 to C10 alkyl, -CH20C(O)CH(R22)(NHR23) wherein R22 is tha side chain of any of the naturally occuring amino acids and R23 is hydrogen or -C(O)CH(R24)(NH2) wherein R24 is the side chain of any of the naturally occuring amino acids, -CH2SH, -CH2C1, -CH2F, -CH2Br, -CH2I, -C(O)H, -CH2CN, -CH2N3, -CH2NR1R2, -CO)2R1, -CH2OH2OH, -CH2CH2OR20 R20 is as defined above, -CH2CH20C(O)R21 wherein R21 is as defined above, -CH2CH20C(O)CH(R22)(NHR23) wherein R22 and R23 are as defined above, -CH2CH2PO3H2, -CH2OPO3H2, -OCH2PO3H2 and -CH2CO2R3 wherein R1 and R2 are independently selected from hydrogen and C1 to 10 alkyl and R3 is hydrogen, C1 to C10 alkyl, carboxyalkyl or aminoalkyl; or a pharmaceutically acceptable salt thereof. (11-1088P)

公开(公告)号：DK529289D0

公开(公告)日：1989-10-24

申请号：DK529289

申请日：1989-10-24

Applicant: ABBOTT LAB

Inventor： NORBECK DANIEL W ,  ROSEN TERRY J ,  PARIZA RICHARD J ,  SOWIN THOMAS J ,  PLATTNER JACOB J ,  GARMAISE DAVID L ,  HANNICK STEVEN M

IPC: C07D251/18 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/4425 ,  A61K31/505 ,  A61K31/52 ,  A61K31/522 ,  A61P31/12 ,  C07C61/04 ,  C07C67/347 ,  C07C69/635 ,  C07C215/42 ,  C07C271/18 ,  C07C271/20 ,  C07C271/24 ,  C07C275/50 ,  C07C321/24 ,  C07D213/69 ,  C07D239/10 ,  C07D239/46 ,  C07D239/47 ,  C07D239/54 ,  C07D251/16 ,  C07D253/06 ,  C07D253/065 ,  C07D403/04 ,  C07D471/04 ,  C07D473/00 ,  C07D473/02 ,  C07D473/18 ,  C07D473/26 ,  C07D473/34 ,  C07D473/40 ,  C07D487/04 ,  C07F7/18 ,  C07F9/38 ,  C07F9/6561 ,  C07C87/34 ,  C07C91/14 ,  C07C125/063 ,  C07C147/06 ,  C07C149/40 ,  C07F9/65

Abstract: A compound of the formula: wherein A is a purin-9-yl group, a heterocyclic isostere of a purin-9-yl group, a pyrimidin-1-yl group or a heterocyclic isostere of a pyrimidin-1-yl group; E is hydrogen, -CH2OH or -OH; and G and D are independently selected from hydrogen, C1 to C10 alkyl, -OH, -CH2OH, -CH2OR20 wherein R20 is C1 to C6 alkyl, -CH2OC(O)R21 wherein R21 is C1 to C10 alkyl, -CH2OC(O)CH(R22)(NHR23) wherein R22 is the side chain of any of the naturally occuring amino acids and R23 is hydrogen or -C(O)CH(R24)(NH2) wherein R24 is the side chain of any of the naturally occuring amino acids, -CH2SH, -CH2Cl, -CH2F, -CH2Br, -CH2I, -C(O)H, -CH2CN, -CH2N3, -CH2NR1R2, -CO2R1, -CH2CH2OH, -CH2CH2OR20 wherein R20 is as defined above, -CH2CH2OC(O)R21 wherein R21 is as defined above -CH2CH2OC(O)CH(R22)(NHR23) wherein R22 and R23 are as defined above -CH2CH2PO3H2, -CH2OPO3H2, -OCH2PO3H2 and -CH2CO2R3 wherein R1 and R2 are independently selected from hydrogen and C1 to C10 alkyl and R3 is hydrogen, C1 to C10 alkyl carboxyalkyl or aminoalkyl; or a pharmaceutically acceptable salt thereof.

公开(公告)号：DK435388A

公开(公告)日：1989-02-05

申请号：DK435388

申请日：1988-08-04

Applicant: ABBOTT LAB

Inventor： ROSEN TERRY J ,  CHU DANIEL T

IPC: A61K31/435 ,  A61K31/47 ,  A61P35/00 ,  C07D401/04 ,  C07D471/04 ,  C07D401/10

Abstract: Naphthyridine and quinoline compounds having the formula: wherein A is CH or N; Z is an amine having the formula: R is o,p-difluorophenyl or p-fluorophenyl; and R1 is hydrogen or a carboxy protecting group. The compounds of the invention have antibacterial activity and improved solubility and pharmacokinetic properties.

公开(公告)号：GR3015404T3

公开(公告)日：1995-06-30

申请号：GR950400557

申请日：1995-03-13

Applicant: ABBOTT LAB

Inventor： ROSEN TERRY J ,  CHU DANIEL T

IPC: A61K31/435 ,  A61K31/47 ,  A61P35/00 ,  C07D401/04 ,  C07D471/04

Abstract: Naphthyridine and quinoline compounds having the formula: wherein A is CH or N; Z is an amine having the formula: R is o,p-difluorophenyl or p-fluorophenyl; and R1 is hydrogen or a carboxy protecting group. The compounds of the invention have antibacterial activity and improved solubility and pharmacokinetic properties.

公开(公告)号：DK169786B1

公开(公告)日：1995-02-27

申请号：DK435388

申请日：1988-08-04

Applicant: ABBOTT LAB

Inventor： ROSEN TERRY J ,  CHU DANIEL T

IPC: A61K31/435 ,  A61K31/47 ,  A61P35/00 ,  C07D401/04 ,  C07D471/04 ,  C07D401/10

Abstract: Naphthyridine and quinoline compounds having the formula: wherein A is CH or N; Z is an amine having the formula: R is o,p-difluorophenyl or p-fluorophenyl; and R1 is hydrogen or a carboxy protecting group. The compounds of the invention have antibacterial activity and improved solubility and pharmacokinetic properties.

公开(公告)号：NZ225584A

公开(公告)日：1990-06-26

申请号：NZ22558488

申请日：1988-07-27

Applicant: ABBOTT LAB

Inventor： ROSEN TERRY J ,  CHU DANIEL T

IPC: A61K31/435 ,  A61K31/47 ,  A61P35/00 ,  C07D401/04 ,  C07D471/04 ,  A61K31/445

Abstract: Naphthyridine and quinoline compounds having the formula: wherein A is CH or N; Z is an amine having the formula: R is o,p-difluorophenyl or p-fluorophenyl; and R1 is hydrogen or a carboxy protecting group. The compounds of the invention have antibacterial activity and improved solubility and pharmacokinetic properties.

公开(公告)号：DE3852442D1

公开(公告)日：1995-01-26

申请号：DE3852442

申请日：1988-07-27

Applicant: ABBOTT LAB

Inventor： ROSEN TERRY J ,  CHU DANIEL T

IPC: A61K31/435 ,  A61K31/47 ,  A61P35/00 ,  C07D401/04 ,  C07D471/04

Abstract: Naphthyridine and quinoline compounds having the formula: wherein A is CH or N; Z is an amine having the formula: R is o,p-difluorophenyl or p-fluorophenyl; and R1 is hydrogen or a carboxy protecting group. The compounds of the invention have antibacterial activity and improved solubility and pharmacokinetic properties.

公开(公告)号：AT115575T

公开(公告)日：1994-12-15

申请号：AT88112103

申请日：1988-07-27

Applicant: ABBOTT LAB

Inventor： ROSEN TERRY J ,  CHU DANIEL T

IPC: A61K31/435 ,  A61K31/47 ,  A61P35/00 ,  C07D401/04 ,  C07D471/04 ,  C07D221/00

Abstract: Naphthyridine and quinoline compounds having the formula: wherein A is CH or N; Z is an amine having the formula: R is o,p-difluorophenyl or p-fluorophenyl; and R1 is hydrogen or a carboxy protecting group. The compounds of the invention have antibacterial activity and improved solubility and pharmacokinetic properties.

公开(公告)号：DK529289A

公开(公告)日：1990-04-26

申请号：DK529289

申请日：1989-10-24

Applicant: ABBOTT LAB

Inventor： NORBECK DANIEL W ,  ROSEN TERRY J ,  PARIZA RICHARD J ,  SOWIN THOMAS J ,  PLATTNER JACOB J ,  GARMAISE DAVID L ,  HANNICK STEVEN M

IPC: C07D251/18 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/4425 ,  A61K31/505 ,  A61K31/52 ,  A61K31/522 ,  A61P31/12 ,  C07C61/04 ,  C07C67/347 ,  C07C69/635 ,  C07C215/42 ,  C07C271/18 ,  C07C271/20 ,  C07C271/24 ,  C07C275/50 ,  C07C321/24 ,  C07D213/69 ,  C07D239/10 ,  C07D239/46 ,  C07D239/47 ,  C07D239/54 ,  C07D251/16 ,  C07D253/06 ,  C07D253/065 ,  C07D403/04 ,  C07D471/04 ,  C07D473/00 ,  C07D473/02 ,  C07D473/18 ,  C07D473/26 ,  C07D473/34 ,  C07D473/40 ,  C07D487/04 ,  C07F7/18 ,  C07F9/38 ,  C07F9/6561 ,  C07C211/34 ,  C07C215/20 ,  C07C271/56 ,  C07C317/44 ,  C07C323/61

Abstract: A compound of the formula: wherein A is a purin-9-yl group, a heterocyclic isostere of a purin-9-yl group, a pyrimidin-1-yl group or a heterocyclic isostere of a pyrimidin-1-yl group; E is hydrogen, -CH2OH or -OH; and G and D are independently selected from hydrogen, C1 to C10 alkyl, -OH, -CH2OH, -CH2OR20 wherein R20 is C1 to C6 alkyl, -CH2OC(O)R21 wherein R21 is C1 to C10 alkyl, -CH2OC(O)CH(R22)(NHR23) wherein R22 is the side chain of any of the naturally occuring amino acids and R23 is hydrogen or -C(O)CH(R24)(NH2) wherein R24 is the side chain of any of the naturally occuring amino acids, -CH2SH, -CH2Cl, -CH2F, -CH2Br, -CH2I, -C(O)H, -CH2CN, -CH2N3, -CH2NR1R2, -CO2R1, -CH2CH2OH, -CH2CH2OR20 wherein R20 is as defined above, -CH2CH2OC(O)R21 wherein R21 is as defined above -CH2CH2OC(O)CH(R22)(NHR23) wherein R22 and R23 are as defined above -CH2CH2PO3H2, -CH2OPO3H2, -OCH2PO3H2 and -CH2CO2R3 wherein R1 and R2 are independently selected from hydrogen and C1 to C10 alkyl and R3 is hydrogen, C1 to C10 alkyl carboxyalkyl or aminoalkyl; or a pharmaceutically acceptable salt thereof.

公开(公告)号：AU2037188A

公开(公告)日：1989-02-09

申请号：AU2037188

申请日：1988-08-03

Applicant: ABBOTT LAB

Inventor： ROSEN TERRY J ,  CHU DANIEL T

IPC: A61K31/435 ,  A61K31/47 ,  A61P35/00 ,  C07D401/04 ,  C07D471/04 ,  C07D401/10 ,  A61K31/44

Abstract: Naphthyridine and quinoline compounds having the formula: wherein A is CH or N; Z is an amine having the formula: R is o,p-difluorophenyl or p-fluorophenyl; and R1 is hydrogen or a carboxy protecting group. The compounds of the invention have antibacterial activity and improved solubility and pharmacokinetic properties.