公开(公告)号：DK0579770T3

公开(公告)日：1996-11-04

申请号：DK92911585

申请日：1992-03-30

Applicant: ABBOTT LAB

Inventor： FREIBERG LESLIE A ,  EDWARDS CARLA ,  PARIZA RICHARD J ,  NELLANS HUGH N

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  C07H17/00 ,  C07H17/02 ,  C07H17/08

Abstract: PCT No. PCT/US92/02590 Sec. 371 Date Aug. 30, 1993 Sec. 102(e) Date Aug. 30, 1993 PCT Filed Mar. 30, 1992Macrocylic lactam compounds of formula (I) ts thereof, wherein A is selected from (II) (III) and (IV) also disclosed are synthetic processes and intermediates useful in the preparation of the compounds of the invention, as well as compositions containing the same and methods for their use in stimulating contractile motion of the gastrointestinal tract.

公开(公告)号：AU663089B2

公开(公告)日：1995-09-28

申请号：AU1910392

申请日：1992-03-30

Applicant: ABBOTT LAB

Inventor： FREIBERG LESLIE A ,  EDWARDS CARLA ,  PARIZA RICHARD J ,  NELLANS HUGH N

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  C07H17/00 ,  C07H17/02 ,  C07H17/08 ,  A61K31/71

Abstract: PCT No. PCT/US92/02590 Sec. 371 Date Aug. 30, 1993 Sec. 102(e) Date Aug. 30, 1993 PCT Filed Mar. 30, 1992Macrocylic lactam compounds of formula (I) ts thereof, wherein A is selected from (II) (III) and (IV) also disclosed are synthetic processes and intermediates useful in the preparation of the compounds of the invention, as well as compositions containing the same and methods for their use in stimulating contractile motion of the gastrointestinal tract.

公开(公告)号：CA1328258C

公开(公告)日：1994-04-05

申请号：CA601931

申请日：1989-06-06

Applicant: ABBOTT LAB

Inventor： PARIZA RICHARD J ,  LARTEY PAUL A ,  MARING CLARENCE J ,  KLEIN LARRY L

IPC: A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61K31/7052 ,  A61P31/00 ,  A61P31/04 ,  C07H17/08 ,  C07H19/04 ,  A61K31/71

Abstract: 9-R-AZACYCLIC ERYTHROMYCIN ANTIBIOTICS Semisynthetic antibiotics with improved therapeutic properties are disclosed. In particular, 9-R-azacyclic derivatives of erythromycin, its derivatives, and their salts and esters show superior antimicrobial activity compared to other macrolide compounds.

公开(公告)号：PT100357A

公开(公告)日：1993-07-30

申请号：PT10035792

申请日：1992-04-08

Applicant: ABBOTT LAB

Inventor： PARIZA RICHARD J ,  FREIBERG LESLIE A ,  EDWARDS CARLA ,  NELLANS HUGH N

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  C07H17/00 ,  C07H17/02 ,  C07H17/08 ,  C07D407/00 ,  A61K31/33

Abstract: PCT No. PCT/US92/02590 Sec. 371 Date Aug. 30, 1993 Sec. 102(e) Date Aug. 30, 1993 PCT Filed Mar. 30, 1992Macrocylic lactam compounds of formula (I) ts thereof, wherein A is selected from (II) (III) and (IV) also disclosed are synthetic processes and intermediates useful in the preparation of the compounds of the invention, as well as compositions containing the same and methods for their use in stimulating contractile motion of the gastrointestinal tract.

公开(公告)号：DK529289A

公开(公告)日：1990-04-26

申请号：DK529289

申请日：1989-10-24

Applicant: ABBOTT LAB

Inventor： NORBECK DANIEL W ,  ROSEN TERRY J ,  PARIZA RICHARD J ,  SOWIN THOMAS J ,  PLATTNER JACOB J ,  GARMAISE DAVID L ,  HANNICK STEVEN M

IPC: C07D251/18 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/4425 ,  A61K31/505 ,  A61K31/52 ,  A61K31/522 ,  A61P31/12 ,  C07C61/04 ,  C07C67/347 ,  C07C69/635 ,  C07C215/42 ,  C07C271/18 ,  C07C271/20 ,  C07C271/24 ,  C07C275/50 ,  C07C321/24 ,  C07D213/69 ,  C07D239/10 ,  C07D239/46 ,  C07D239/47 ,  C07D239/54 ,  C07D251/16 ,  C07D253/06 ,  C07D253/065 ,  C07D403/04 ,  C07D471/04 ,  C07D473/00 ,  C07D473/02 ,  C07D473/18 ,  C07D473/26 ,  C07D473/34 ,  C07D473/40 ,  C07D487/04 ,  C07F7/18 ,  C07F9/38 ,  C07F9/6561 ,  C07C211/34 ,  C07C215/20 ,  C07C271/56 ,  C07C317/44 ,  C07C323/61

Abstract: A compound of the formula: wherein A is a purin-9-yl group, a heterocyclic isostere of a purin-9-yl group, a pyrimidin-1-yl group or a heterocyclic isostere of a pyrimidin-1-yl group; E is hydrogen, -CH2OH or -OH; and G and D are independently selected from hydrogen, C1 to C10 alkyl, -OH, -CH2OH, -CH2OR20 wherein R20 is C1 to C6 alkyl, -CH2OC(O)R21 wherein R21 is C1 to C10 alkyl, -CH2OC(O)CH(R22)(NHR23) wherein R22 is the side chain of any of the naturally occuring amino acids and R23 is hydrogen or -C(O)CH(R24)(NH2) wherein R24 is the side chain of any of the naturally occuring amino acids, -CH2SH, -CH2Cl, -CH2F, -CH2Br, -CH2I, -C(O)H, -CH2CN, -CH2N3, -CH2NR1R2, -CO2R1, -CH2CH2OH, -CH2CH2OR20 wherein R20 is as defined above, -CH2CH2OC(O)R21 wherein R21 is as defined above -CH2CH2OC(O)CH(R22)(NHR23) wherein R22 and R23 are as defined above -CH2CH2PO3H2, -CH2OPO3H2, -OCH2PO3H2 and -CH2CO2R3 wherein R1 and R2 are independently selected from hydrogen and C1 to C10 alkyl and R3 is hydrogen, C1 to C10 alkyl carboxyalkyl or aminoalkyl; or a pharmaceutically acceptable salt thereof.

公开(公告)号：DK276289D0

公开(公告)日：1989-06-06

申请号：DK276289

申请日：1989-06-06

Applicant: ABBOTT LAB

Inventor： PARIZA RICHARD J ,  LARTEY PAUL A ,  MARING CLARENCE J ,  KLEIN LARRY L

IPC: A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61K31/7052 ,  A61P31/00 ,  A61P31/04 ,  C07H17/08 ,  C07H19/04

Abstract: Semisynthetic antibiotics with improved therapeutic properties are disclosed. In particular, 9-R-azacyclic derivatives of erythromycin, its derivatives, and their salts and esters show superior antimicrobial activity compared to other macrolide compounds.

公开(公告)号：AT151772T

公开(公告)日：1997-05-15

申请号：AT89109890

申请日：1989-06-01

Applicant: ABBOTT LAB

Inventor： PARIZA RICHARD J ,  MARING CLARENCE J ,  LARTEY PAUL A ,  KLEIN LARRY L

IPC: A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61K31/7052 ,  A61P31/00 ,  A61P31/04 ,  C07H17/08 ,  C07H19/04

Abstract: Semisynthetic antibiotics with improved therapeutic properties are disclosed. In particular, 9-R-azacyclic derivatives of erythromycin, its derivatives, and their salts and esters show superior antimicrobial activity compared to other macrolide compounds.

公开(公告)号：AT139697T

公开(公告)日：1996-07-15

申请号：AT92911585

申请日：1992-03-30

Applicant: ABBOTT LAB

Inventor： FREIBERG LESLIE A ,  EDWARDS CARLA ,  PARIZA RICHARD J ,  NELLANS HUGH N

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  C07H17/00 ,  C07H17/02 ,  C07H17/08

Abstract: PCT No. PCT/US92/02590 Sec. 371 Date Aug. 30, 1993 Sec. 102(e) Date Aug. 30, 1993 PCT Filed Mar. 30, 1992Macrocylic lactam compounds of formula (I) ts thereof, wherein A is selected from (II) (III) and (IV) also disclosed are synthetic processes and intermediates useful in the preparation of the compounds of the invention, as well as compositions containing the same and methods for their use in stimulating contractile motion of the gastrointestinal tract.

公开(公告)号：AU609307B2

公开(公告)日：1991-04-26

申请号：AU3610289

申请日：1989-06-06

Applicant: ABBOTT LAB

Inventor： KLEIN LARRY L ,  MARING CLARENCE J ,  LARTEY PAUL A ,  PARIZA RICHARD J

IPC: A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61K31/7052 ,  A61P31/00 ,  A61P31/04 ,  C07H17/08 ,  C07H19/04 ,  A61K31/71

Abstract: Semisynthetic antibiotics with improved therapeutic properties are disclosed. In particular, 9-R-azacyclic derivatives of erythromycin, its derivatives, and their salts and esters show superior antimicrobial activity compared to other macrolide compounds.

公开(公告)号：ZA856086B

公开(公告)日：1986-03-26

申请号：ZA856086

申请日：1985-08-12

Applicant: ABBOTT LAB

Inventor： PARIZA RICHARD J ,  FREIBERG LESLIE A

IPC: C07H17/08 ,  A61K ,  C07B ,  C07G ,  C12P

Abstract: O-Alkylated derivatives of macrolide antibiotics which exhibit improved antibiotic activity can be prepared from parent macrolides having a plurality of reactive hydroxyl groups via a two-step process involving, first, protective esterification of the hydroxy-amino sugar moiety, followed by alkylation at one or more of the remaining hydroxyl groups.