公开(公告)号：WO9429456A3

公开(公告)日：1995-03-02

申请号：PCT/US9405920

申请日：1994-05-25

Applicant: ABBOTT LAB

Inventor： STEFFY KEVIN R ,  KATI WARREN M ,  KATZ LEONARD ,  MCGONIGAL THOMAS P ,  SARTHY APARNA V ,  SCHOEN SHARON E

IPC: C12N15/09 ,  C07K16/08 ,  C12N1/19 ,  C12N1/21 ,  C12N9/50 ,  C12N15/57 ,  C12R1/19 ,  C12R1/865 ,  C12R1/92 ,  C12N5/10

CPC classification number: C07K16/087 ,  C12N9/503

Abstract: Protease activity associated with herpes simplex virus (HSV) type 2 was identified. The complete nucleotide and amino acid sequence of the protease was determined. The HSV-2 nucleic acid segment encoding the protease substrate ICP35 was also sequenced. Recombinant vectors and host cells for expressing the protease are also described.