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1.发明专利Azaadamantane derivatives and their uses as nicotinic acetylcholine receptors ligands 有权亚胺丹衍生物及其作为NICOTINIC乙酰胆碱受体配体的用途
公开(公告)号：JP2013121969A
公开(公告)日：2013-06-20
申请号：JP2013008959
申请日：2013-01-22
Applicant: Abbott Lab , アボット・ラボラトリーズAbbott Laboratories
Inventor： SCHRIMPF MICHAEL R , NERSESIAN DIANA L , SIPPY KEVIN B , JI JIANGUO , LI TAO , SCANIO MARC , SHI LEI , LEE CHIH-HUNG , BUNNELLE WILLIAM H , ZHANG GEOFF G Z , BRACKEMEYER PAUL J , CHEN SHUANG , HENRY RODGER F
IPC: C07D471/18 , A61K31/439 , A61K31/444 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61P3/10 , A61P9/00 , A61P9/10 , A61P15/08 , A61P17/02 , A61P19/02 , A61P21/02 , A61P25/04 , A61P25/14 , A61P25/18 , A61P25/28 , A61P25/34 , A61P29/00 , A61P43/00
CPC classification number: C07D471/18 , A61K31/095 , A61K31/439 , A61K31/444 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K45/06 , C07C309/29 , C07D451/14 , C07D471/08 , C07F5/022
Abstract: PROBLEM TO BE SOLVED: To provide novel azaadamantane derivatives.SOLUTION: The invention relates to compounds that are azaadamantane derivatives of formula (I), particularly ether- or amine-substituted azaadamantane derivatives and salts and prodrugs thereof. In the formula, Ldenotes -O- or -NR-; A denotes -Ar, -Ar-L-Aror -Ar-L-Ar; Ardenotes aryl or heteroaryl; Ardenotes aryl or monocyclic heteroaryl; Ardenotes aryl or heteroaryl; Ardenotes bicyclic heteroaryl; Ardenotes aryl or heteroaryl; Ldenotes a binding, -O -, -NR-, -CH- or -C(O)NR-; L3 denotes a binding, -O-, -NR-or -CH-; and Rdenotes hydrogen or alkyl.
Abstract translation: 待解决的问题：提供新的氮杂金刚烷衍生物。 解决方案：本发明涉及式（I）的氮杂金刚烷衍生物，特别是醚或胺取代的氮杂金刚烷衍生物及其盐和前药的化合物。 在该式中，L
1 表示-O-或-NR a - ; A表示-Ar 1 ，-Ar 2 -L 2 3 或-Ar 4 -L 3 -Ar 5 ; Ar 1 表示芳基或杂芳基; Ar 2表示芳基或单环杂芳基; Ar 3 表示芳基或杂芳基; Ar 4 表示双环杂芳基; Ar 5 表示芳基或杂芳基; L 2 表示结合，-O - ， - NR a - ，-CH 2 - 或-C（O）NR a - ; L3表示结合，-O-，-NR a - 或-CH 2 并且R a 表示氢或烷基。 版权所有（C）2013，JPO＆INPIT -
公开(公告)号：JP2012041349A
公开(公告)日：2012-03-01
申请号：JP2011202172
申请日：2011-09-15
Applicant: Abbott Lab , アボット・ラボラトリーズAbbott Laboratories
Inventor： SCHRIMPF MICHAEL R , TIETJE KARIN R , TOUPENCE RICHARD B , JI JIANGUO , BASHA ANWER , BUNNELLE WILLIAM H , DAANEN JEROME F , PACE JENNIFER M , SIPPY KEVIN B
IPC: C07D231/54 , C07D487/04 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4545 , A61P25/00 , A61P25/04 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P25/34 , C07D471/04
CPC classification number: C07D471/04 , C07D487/04
Abstract: PROBLEM TO BE SOLVED: To provide a series of N-substituted diazabicyclic compound, a method for selectively controlling releasing of a synaptic transmission substance in mammals by using the compound, and a pharmaceutical composition including the compound.SOLUTION: The present invention provides a compound expressed by formula (I), a pharmaceutical composition of the compound, and use of the composition to control synaptic transmission in mammals (in a nicotinic acetylcholine receptor ligand). In formula (I), A is selected from a group consisting of CH2, CH2CH2, and the like; B is selected from a group consisting of CH2 and CH2CH2, however, when A is CH2CH2CH2, B is CH2; Y is selected from a group consisting of CH2 and CH2CH2; Z is selected from a group consisting of CH2 and CH2CH2, however, when Y is CH2CH2, Z is a covalent bond, and when Z is CH2CH2, Y is a covalent bond; and Rl is pyridine or the like.
Abstract translation: 待解决的问题：提供一系列N-取代的二氮杂双环化合物，通过使用该化合物选择性地控制哺乳动物突触传递物质的释放的方法和包含该化合物的药物组合物。 解决方案：本发明提供由式（I）表示的化合物，该化合物的药物组合物，以及该组合物用于控制哺乳动物（在烟碱乙酰胆碱受体配体）中突触传递的用途。 在式（I）中，A选自由CH 2，CH 2 CH 2等组成的组; B选自CH 2和CH 2 CH 2，但是当A是CH 2 CH 2 CH 2时，B是CH 2; Y选自CH 2和CH 2 CH 2; Z选自CH 2和CH 2 CH 2，但是当Y为CH 2 CH 2时，Z为共价键，当Z为CH 2 CH 2时，Y为共价键; 并且R 1是吡啶等。 版权所有（C）2012，JPO＆INPIT
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3.发明申请AZAADAMANTANE DERIVATIVES AND THEIR USES AS NICOTINIC ACETYLCHOLINE RECEPTORS LIGANDS 审中-公开亚胺丹衍生物及其作为NICOTINIC乙酰胆碱受体配体使用
公开(公告)号：WO2008058096A3
公开(公告)日：2008-08-07
申请号：PCT/US2007083687
申请日：2007-11-06
Applicant: ABBOTT LAB , SCHRIMPF MICHAEL R , NERSESIAN DIANA L , SIPPY KEVIN B , JI JIANGUO , LI TAO , SCANIO MARC , SHI LEI , LEE CHIH-HUNG , BUNNELLE WILLAIM H , ZHANG GEOFF G Z , BRACKEMEYER PAUL J , CHEN SHUANG , HENRY RODGER F
Inventor： SCHRIMPF MICHAEL R , NERSESIAN DIANA L , SIPPY KEVIN B , JI JIANGUO , LI TAO , SCANIO MARC , SHI LEI , LEE CHIH-HUNG , BUNNELLE WILLAIM H , ZHANG GEOFF G Z , BRACKEMEYER PAUL J , CHEN SHUANG , HENRY RODGER F
IPC: C07D451/14 , A61K31/395
CPC classification number: C07D471/18 , A61K31/095 , A61K31/439 , A61K31/444 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K45/06 , C07C309/29 , C07D451/14 , C07D471/08 , C07F5/022
Abstract: The invention relates to compounds that are azaadamantane derivatives of formula (I), particularly ether- or amine -substituted azaadamantane derivatives and salts and prodrugs thereof, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.
Abstract translation: 本发明涉及作为式（I）的氮杂金刚烷衍生物的化合物，特别是醚或胺取代的氮杂金刚烷衍生物及其盐和前药，包含这些化合物的组合物，使用这些化合物和组合物的方法，制备这些化合物的方法和 在此过程中获得的中间体。
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公开(公告)号：WO2011008312A3
公开(公告)日：2011-03-17
申请号：PCT/US2010027931
申请日：2010-03-19
Applicant: ABBOTT LAB , SCHRIMPF MICHAEL R , LEE CHIH-HUNG , LI TAO , GFESSER GREGORY A , MORTELL KATHLEEN H , FAGHIH RAMIN , NERSESIAN DIANA L , SIPPY KEVIN B , BUNNELLE WILLIAM H , SCANIO MARC , SHI LEI , GOPALAKRISHNAN MURALI , DONNELLY-ROBERTS DIANA L , HU MIN
Inventor： SCHRIMPF MICHAEL R , LEE CHIH-HUNG , LI TAO , GFESSER GREGORY A , MORTELL KATHLEEN H , FAGHIH RAMIN , NERSESIAN DIANA L , SIPPY KEVIN B , BUNNELLE WILLIAM H , SCANIO MARC , SHI LEI , GOPALAKRISHNAN MURALI , DONNELLY-ROBERTS DIANA L , HU MIN
IPC: C07D487/18 , A61K31/33 , A61P25/00 , C07D471/18
CPC classification number: C07D471/18 , C07D487/18
Abstract: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
Abstract translation: 本发明涉及式（I），（II），（III），（IV），（V）或（VI）的吲哚和吲哚啉衍生物，其中a，R1，R2，R3，R4，R5， V，W，X，Y和Z如说明书中所定义。 本申请还涉及包含此类化合物的组合物，以及使用此类化合物和组合物治疗疾病状况的方法，以及鉴定此类化合物的方法。
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公开(公告)号：WO2005077899A3
公开(公告)日：2005-12-01
申请号：PCT/US2005003578
申请日：2005-02-04
Applicant: ABBOTT LAB , SCHRIMPF MICHAEL R , SIPPY KEVIN B , JI JIANGUO , LI TAO , PACE JENNIFER M , BRIGGS CLARK A , BUNELLE WILLIAM H
Inventor： SCHRIMPF MICHAEL R , SIPPY KEVIN B , JI JIANGUO , LI TAO , PACE JENNIFER M , BRIGGS CLARK A , BUNELLE WILLIAM H
IPC: C07C211/25 , C07C211/31 , C07C217/24 , C07C217/42 , C07D205/04 , C07D207/08 , C07D207/12 , C07D207/14 , C07D209/88 , C07D211/22 , C07D211/46 , C07D243/08 , C07D295/104 , C07D307/91 , C07D311/86 , C07D333/76 , C07D451/06 , C07D453/02 , C07D487/04 , C07D487/08 , C07D519/00 , C07D295/10
CPC classification number: C07D207/08 , C07C211/31 , C07C217/24 , C07C2603/18 , C07C2603/26 , C07D205/04 , C07D207/12 , C07D207/14 , C07D209/88 , C07D211/22 , C07D211/46 , C07D243/08 , C07D295/104 , C07D307/91 , C07D311/86 , C07D333/76 , C07D451/06 , C07D453/02 , C07D487/04 , C07D487/08
Abstract: Compounds of formula (I) wherein A and B are amine-substituted sidechains, Y and Y form various tricyclic cores, X and X are C, CH, or N, as defined herein, and R is an optional substituent. Compounds and compositions of formula (I) are contemplated as well as methods for treating conditions or disorders prevented by or ameliorated by alpha7 nAChR ligands that encompass compounds of formula (I) and other tricyclic derivatives. Methods of using amino-substituted tricyclic derivatives also are described herein.
Abstract translation: 其中A和B是胺取代的侧链的式（I）化合物，Y 1和Y 2形成各种三环核，X a和X b是如本文所定义的C，CH或N ，R x是任选的取代基。 考虑式（I）的化合物和组合物以及用于治疗由包括式（I）化合物和其它三环衍生物的α7nAChR配体防止或改善的病症或病症的方法。 使用氨基取代的三环衍生物的方法也在本文中描述。
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Patent Agency Ranking
公开(公告)号：WO2010036998A3
公开(公告)日：2011-03-03
申请号：PCT/US2009058553
申请日：2009-09-28
Applicant: ABBOTT LAB , SCHRIMPF MICHAEL R , LEE CHIH-HUNG , LI TAO , GFESSER GREGORY A , MORTELL KATHLEEN H , FAGHIH RAMIN , NERSESIAN DIANA L , SIPPY KEVIN B , BUNNELLE WILLIAM H , SCANIO MARC , SHI LEI , GOPALAKRISHNAN MURALI , DONNELLY-ROBERTS DIANA , HU MIN
Inventor： SCHRIMPF MICHAEL R , LEE CHIH-HUNG , LI TAO , GFESSER GREGORY A , MORTELL KATHLEEN H , FAGHIH RAMIN , NERSESIAN DIANA L , SIPPY KEVIN B , BUNNELLE WILLIAM H , SCANIO MARC , SHI LEI , GOPALAKRISHNAN MURALI , DONNELLY-ROBERTS DIANA , HU MIN
IPC: C07D487/18 , A61K31/33 , A61P25/00
CPC classification number: G01N33/5058 , C07D471/18 , C07D487/10 , C07D487/18 , G01N33/6896 , G01N2800/28 , G01N2800/30
Abstract: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
Abstract translation: 本申请涉及式（I），（II），（III），（IV），（V）或（VI）的吲哚和二氢吲哚衍生物，其中a，R1，R2，R3，R4，R5， V，W，X，Y和Z如说明书中所定义。 本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗疾病状况的方法，以及鉴定这些化合物的方法。
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公开(公告)号：WO2008073942A3
公开(公告)日：2008-12-04
申请号：PCT/US2007087090
申请日：2007-12-12
Applicant: ABBOTT LAB , GOPALAKRISHNAN MURALI , HONORE MARIE P , LEE CHIH-HUNG , MALYSZ JOHN , JI JIANGUO , LI TAO , SCHRIMPF MICHAEL R , SIPPY KEVIN B , ANDERSON DAVID J
Inventor： GOPALAKRISHNAN MURALI , HONORE MARIE P , LEE CHIH-HUNG , MALYSZ JOHN , JI JIANGUO , LI TAO , SCHRIMPF MICHAEL R , SIPPY KEVIN B , ANDERSON DAVID J
IPC: A61K31/4245 , A61K45/06 , A61P25/28
CPC classification number: A61K31/4439 , A61K31/4245 , A61K31/4427 , A61K31/443 , A61K31/444 , A61K31/4709 , A61K45/06 , C07D413/04 , C07D413/14 , G01N33/944 , G01N2333/70571 , A61K2300/00
Abstract: The invention relates to a composition comprising a neuronal nicotinic receptor ligand and an a4ß2 positive allosteric modulator, a method of using the same, and a related article of manufacture.
Abstract translation: 本发明涉及包含神经元烟碱受体配体和α4β2正变构调节剂的组合物，使用该组合物的方法和相关的制造物品。
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8.发明申请TERTIARY AND SECONDARY AMINES AS ALPHA-2 ANTAGONISTS AND SEROTONIN UPTAKE INHIBITORS 审中-公开碱性和二级氨基酸作为ALPHA-2拮抗剂和丝氨酸摄取抑制剂
公开(公告)号：WO9312754A3
公开(公告)日：2000-10-12
申请号：PCT/US9210794
申请日：1992-12-14
Applicant: ABBOTT LAB , MEYER MICHAEL D , DEBERNARDIS JOHN F , PRASAD RAJNANDAN , SIPPY KEVIN B , TIETJE KARIN R
Inventor： MEYER MICHAEL D , DEBERNARDIS JOHN F , PRASAD RAJNANDAN , SIPPY KEVIN B , TIETJE KARIN R
IPC: C07D317/58 , A61K31/135 , A61K31/165 , A61K31/352 , A61K31/357 , A61K31/36 , A61K31/382 , A61K31/4035 , A61K31/404 , A61K31/416 , A61K31/4184 , A61K31/423 , A61K31/4245 , A61K31/428 , A61K31/433 , A61K31/47 , A61K31/472 , A61K31/498 , A61K31/538 , A61K31/5415 , A61P9/00 , A61P9/10 , A61P9/12 , A61P25/00 , A61P25/06 , A61P25/18 , A61P25/24 , A61P25/28 , A61P25/30 , A61P27/06 , A61P43/00 , C07C217/58 , C07C217/74 , C07D209/08 , C07D209/14 , C07D209/44 , C07D209/48 , C07D215/12 , C07D217/02 , C07D217/04 , C07D231/56 , C07D235/06 , C07D235/14 , C07D241/42 , C07D263/56 , C07D263/58 , C07D265/36 , C07D271/08 , C07D275/04 , C07D277/64 , C07D277/68 , C07D277/82 , C07D279/02 , C07D279/10 , C07D279/16 , C07D285/14 , C07D307/78 , C07D307/79 , C07D311/58 , C07D311/76 , C07D319/08 , C07D319/18 , C07D327/04 , C07D333/54 , C07D333/58 , C07D333/72 , C07D335/06 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D301/79 , A61K31/34 , A61K31/38 , C07D307/83 , C07D307/87 , C07D307/88 , C07D333/64
CPC classification number: C07D209/48 , C07C217/74 , C07C2602/10 , C07D209/08 , C07D209/14 , C07D209/44 , C07D215/12 , C07D217/02 , C07D235/06 , C07D241/42 , C07D263/56 , C07D263/58 , C07D277/64 , C07D277/68 , C07D277/82 , C07D307/79 , C07D327/04 , C07D333/54 , C07D333/58 , C07D333/72 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/10 , C07D417/12
Abstract: The present invention provides an amine compound of formula (I) or a pharmaceutically acceptable salt thereof which is an antagonist for alpha-2 adrenoreceptors and which inhibits serotonin (5-hydroxytryptamine, 5-HT) uptake.
Abstract translation: 本发明提供了式（I）的胺化合物或其药学上可接受的盐，其是α-2肾上腺素受体的拮抗剂并且其抑制5-羟色胺（5-羟色胺，5-HT）摄取。
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公开(公告)号：EP2129672A4
公开(公告)日：2009-12-09
申请号：EP08732552
申请日：2008-03-20
Applicant: ABBOTT LAB
Inventor： SCHRIMPF MICHAEL R , NERSESIAN DIANA L , SIPPY KEVIN B , JI JIANGUO , LI TAO , SHI LEI
IPC: C07D471/18 , A61K31/439 , A61P25/16 , A61P25/28
CPC classification number: C07D471/18
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10.发明公开TERTIARY AND SECONDARY AMINES AS ALPHA-2 ANTAGONISTS AND SEROTONIN UPTAKE INHIBITORS. 失效TERTIÄREUNDSEKUNDÄREAMINE ALS ALPHA-2 ANTAGONISTEN UND SEROTONINAUFNAHMEINHIBITOREN。
公开(公告)号：EP0646112A4
公开(公告)日：1997-04-02
申请号：EP93901313
申请日：1992-12-14
Applicant: ABBOTT LAB
Inventor： MEYER MICHAEL D , DEBERNARDIS JOHN F , PRASAD RAJNANDAN , SIPPY KEVIN B , TIETJE KARIN R
IPC: C07D317/58 , A61K31/135 , A61K31/165 , A61K31/352 , A61K31/357 , A61K31/36 , A61K31/382 , A61K31/4035 , A61K31/404 , A61K31/416 , A61K31/4184 , A61K31/423 , A61K31/4245 , A61K31/428 , A61K31/433 , A61K31/47 , A61K31/472 , A61K31/498 , A61K31/538 , A61K31/5415 , A61P9/00 , A61P9/10 , A61P9/12 , A61P25/00 , A61P25/06 , A61P25/18 , A61P25/24 , A61P25/28 , A61P25/30 , A61P27/06 , A61P43/00 , C07C217/58 , C07C217/74 , C07D209/08 , C07D209/14 , C07D209/44 , C07D209/48 , C07D215/12 , C07D217/02 , C07D217/04 , C07D231/56 , C07D235/06 , C07D235/14 , C07D241/42 , C07D263/56 , C07D263/58 , C07D265/36 , C07D271/08 , C07D275/04 , C07D277/64 , C07D277/68 , C07D277/82 , C07D279/02 , C07D279/10 , C07D279/16 , C07D285/14 , C07D307/78 , C07D307/79 , C07D311/58 , C07D311/76 , C07D319/08 , C07D319/18 , C07D327/04 , C07D333/54 , C07D333/58 , C07D333/72 , C07D335/06 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D339/00 , A61K31/00
CPC classification number: C07D209/48 , C07C217/74 , C07C2602/10 , C07D209/08 , C07D209/14 , C07D209/44 , C07D215/12 , C07D217/02 , C07D235/06 , C07D241/42 , C07D263/56 , C07D263/58 , C07D277/64 , C07D277/68 , C07D277/82 , C07D307/79 , C07D327/04 , C07D333/54 , C07D333/58 , C07D333/72 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/10 , C07D417/12
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