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1.发明申请TERTIARY AND SECONDARY AMINES AS ALPHA-2 ANTAGONISTS AND SEROTONIN UPTAKE INHIBITORS 审中-公开碱性和二级氨基酸作为ALPHA-2拮抗剂和丝氨酸摄取抑制剂
公开(公告)号：WO9312754A3
公开(公告)日：2000-10-12
申请号：PCT/US9210794
申请日：1992-12-14
Applicant: ABBOTT LAB , MEYER MICHAEL D , DEBERNARDIS JOHN F , PRASAD RAJNANDAN , SIPPY KEVIN B , TIETJE KARIN R
Inventor： MEYER MICHAEL D , DEBERNARDIS JOHN F , PRASAD RAJNANDAN , SIPPY KEVIN B , TIETJE KARIN R
IPC: C07D317/58 , A61K31/135 , A61K31/165 , A61K31/352 , A61K31/357 , A61K31/36 , A61K31/382 , A61K31/4035 , A61K31/404 , A61K31/416 , A61K31/4184 , A61K31/423 , A61K31/4245 , A61K31/428 , A61K31/433 , A61K31/47 , A61K31/472 , A61K31/498 , A61K31/538 , A61K31/5415 , A61P9/00 , A61P9/10 , A61P9/12 , A61P25/00 , A61P25/06 , A61P25/18 , A61P25/24 , A61P25/28 , A61P25/30 , A61P27/06 , A61P43/00 , C07C217/58 , C07C217/74 , C07D209/08 , C07D209/14 , C07D209/44 , C07D209/48 , C07D215/12 , C07D217/02 , C07D217/04 , C07D231/56 , C07D235/06 , C07D235/14 , C07D241/42 , C07D263/56 , C07D263/58 , C07D265/36 , C07D271/08 , C07D275/04 , C07D277/64 , C07D277/68 , C07D277/82 , C07D279/02 , C07D279/10 , C07D279/16 , C07D285/14 , C07D307/78 , C07D307/79 , C07D311/58 , C07D311/76 , C07D319/08 , C07D319/18 , C07D327/04 , C07D333/54 , C07D333/58 , C07D333/72 , C07D335/06 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D301/79 , A61K31/34 , A61K31/38 , C07D307/83 , C07D307/87 , C07D307/88 , C07D333/64
CPC classification number: C07D209/48 , C07C217/74 , C07C2602/10 , C07D209/08 , C07D209/14 , C07D209/44 , C07D215/12 , C07D217/02 , C07D235/06 , C07D241/42 , C07D263/56 , C07D263/58 , C07D277/64 , C07D277/68 , C07D277/82 , C07D307/79 , C07D327/04 , C07D333/54 , C07D333/58 , C07D333/72 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/10 , C07D417/12
Abstract: The present invention provides an amine compound of formula (I) or a pharmaceutically acceptable salt thereof which is an antagonist for alpha-2 adrenoreceptors and which inhibits serotonin (5-hydroxytryptamine, 5-HT) uptake.
Abstract translation: 本发明提供了式（I）的胺化合物或其药学上可接受的盐，其是α-2肾上腺素受体的拮抗剂并且其抑制5-羟色胺（5-羟色胺，5-HT）摄取。
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2.发明公开TERTIARY AND SECONDARY AMINES AS ALPHA-2 ANTAGONISTS AND SEROTONIN UPTAKE INHIBITORS. 失效TERTIÄREUNDSEKUNDÄREAMINE ALS ALPHA-2 ANTAGONISTEN UND SEROTONINAUFNAHMEINHIBITOREN。
公开(公告)号：EP0646112A4
公开(公告)日：1997-04-02
申请号：EP93901313
申请日：1992-12-14
Applicant: ABBOTT LAB
Inventor： MEYER MICHAEL D , DEBERNARDIS JOHN F , PRASAD RAJNANDAN , SIPPY KEVIN B , TIETJE KARIN R
IPC: C07D317/58 , A61K31/135 , A61K31/165 , A61K31/352 , A61K31/357 , A61K31/36 , A61K31/382 , A61K31/4035 , A61K31/404 , A61K31/416 , A61K31/4184 , A61K31/423 , A61K31/4245 , A61K31/428 , A61K31/433 , A61K31/47 , A61K31/472 , A61K31/498 , A61K31/538 , A61K31/5415 , A61P9/00 , A61P9/10 , A61P9/12 , A61P25/00 , A61P25/06 , A61P25/18 , A61P25/24 , A61P25/28 , A61P25/30 , A61P27/06 , A61P43/00 , C07C217/58 , C07C217/74 , C07D209/08 , C07D209/14 , C07D209/44 , C07D209/48 , C07D215/12 , C07D217/02 , C07D217/04 , C07D231/56 , C07D235/06 , C07D235/14 , C07D241/42 , C07D263/56 , C07D263/58 , C07D265/36 , C07D271/08 , C07D275/04 , C07D277/64 , C07D277/68 , C07D277/82 , C07D279/02 , C07D279/10 , C07D279/16 , C07D285/14 , C07D307/78 , C07D307/79 , C07D311/58 , C07D311/76 , C07D319/08 , C07D319/18 , C07D327/04 , C07D333/54 , C07D333/58 , C07D333/72 , C07D335/06 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D339/00 , A61K31/00
CPC classification number: C07D209/48 , C07C217/74 , C07C2602/10 , C07D209/08 , C07D209/14 , C07D209/44 , C07D215/12 , C07D217/02 , C07D235/06 , C07D241/42 , C07D263/56 , C07D263/58 , C07D277/64 , C07D277/68 , C07D277/82 , C07D307/79 , C07D327/04 , C07D333/54 , C07D333/58 , C07D333/72 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/10 , C07D417/12
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3.发明专利
公开(公告)号：GR3030342T3
公开(公告)日：1999-09-30
申请号：GR990401431
申请日：1999-05-27
Applicant: ABBOTT LAB
Inventor： BAKER WILLIAM R , ROCKWAY TODD W , DONNER B GREGORY , SHEN WANG , ROSENBERG SAUL H , FAKHOURY STEPHEN A , O'CONNOR STEPHEN J , STOUT DAVID M , FUNG ANTHONY K L , GARVEY DAVID S , PRASAD RAJNANDAN , SULLIVAN GERARD M
IPC: C12N9/99 , A61K31/195 , A61K31/215 , A61K31/34 , A61K31/341 , A61K31/357 , A61K31/36 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/41 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61P3/06 , A61P7/00 , A61P9/10 , A61P31/04 , A61P43/00 , C07C69/52 , C07C69/74 , C07C231/02 , C07C233/19 , C07C233/58 , C07C233/59 , C07C233/60 , C07C233/61 , C07C233/62 , C07C233/63 , C07C235/36 , C07C235/40 , C07C237/24 , C07C245/14 , C07C251/42 , C07C259/08 , C07C275/26 , C07C311/51 , C07C323/40 , C07C323/46 , C07C327/20 , C07C327/36 , C07C327/38 , C07D207/325 , C07D213/40 , C07D257/04 , C07D257/06 , C07D263/24 , C07D271/06 , C07D271/10 , C07D277/20 , C07D277/34 , C07D285/16 , C07D285/18 , C07D307/42 , C07D307/52 , C07D309/32 , C07D317/60 , C07D319/06 , C07D333/08 , C07D333/58 , A61K31/16
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4.发明专利
公开(公告)号：CA2152822A1
公开(公告)日：1995-05-11
申请号：CA2152822
申请日：1994-10-20
Applicant: ABBOTT LAB
Inventor： BAKER WILLIAM R , ROCKWAY TODD W , DONNER B GREGORY , SHEN WANG , ROSENBERG SAUL H , FAKHOURY STEPHEN A , O'CONNOR STEPHEN J , STOUT DAVID M , FUNG ANTHONY K L , GARVEY DAVID S , PRASAD RAJNANDAN , SULLIVAN GERARD M
IPC: C12N9/99 , A61K31/195 , A61K31/215 , A61K31/34 , A61K31/341 , A61K31/357 , A61K31/36 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/41 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61P3/06 , A61P7/00 , A61P9/10 , A61P31/04 , A61P43/00 , C07C69/52 , C07C69/74 , C07C231/02 , C07C233/19 , C07C233/58 , C07C233/59 , C07C233/60 , C07C233/61 , C07C233/62 , C07C233/63 , C07C235/36 , C07C235/40 , C07C237/24 , C07C245/14 , C07C251/42 , C07C259/08 , C07C275/26 , C07C311/51 , C07C323/40 , C07C323/46 , C07C327/20 , C07C327/36 , C07C327/38 , C07D207/325 , C07D213/40 , C07D257/04 , C07D257/06 , C07D263/24 , C07D271/06 , C07D271/10 , C07D277/20 , C07D277/34 , C07D285/16 , C07D285/18 , C07D307/42 , C07D307/52 , C07D309/32 , C07D317/60 , C07D319/06 , C07D333/08 , C07D333/58 , C07C235/82 , A61K31/33 , C07D207/337 , C07D249/02 , C07D285/06 , C07D307/54 , C07D333/24
Abstract: The present invention provides a compound of formula (I) processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and a method of treating disorders resulting from an excess of cholesterol or cancer or a fungal infection.
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公开(公告)号：AT177420T
公开(公告)日：1999-03-15
申请号：AT94931987
申请日：1994-10-20
Applicant: ABBOTT LAB
Inventor： BAKER WILLIAM R , ROCKWAY TODD W , DONNER B GREGORY , SHEN WANG , ROSENBERG SAUL H , FAKHOURY STEPHEN A , O'CONNOR STEPHEN J , STOUT DAVID M , FUNG ANTHONY K L , GARVEY DAVID S , PRASAD RAJNANDAN , SULLIVAN GERARD M
IPC: C12N9/99 , A61K31/195 , A61K31/215 , A61K31/34 , A61K31/341 , A61K31/357 , A61K31/36 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/41 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61P3/06 , A61P7/00 , A61P9/10 , A61P31/04 , A61P43/00 , C07C69/52 , C07C69/74 , C07C231/02 , C07C233/19 , C07C233/58 , C07C233/59 , C07C233/60 , C07C233/61 , C07C233/62 , C07C233/63 , C07C235/36 , C07C235/40 , C07C237/24 , C07C245/14 , C07C251/42 , C07C259/08 , C07C275/26 , C07C311/51 , C07C323/40 , C07C323/46 , C07C327/20 , C07C327/36 , C07C327/38 , C07D207/325 , C07D213/40 , C07D257/04 , C07D257/06 , C07D263/24 , C07D271/06 , C07D271/10 , C07D277/20 , C07D277/34 , C07D285/16 , C07D285/18 , C07D307/42 , C07D307/52 , C07D309/32 , C07D317/60 , C07D319/06 , C07D333/08 , C07D333/58 , A61K31/16
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Patent Agency Ranking
公开(公告)号：DK0677039T3
公开(公告)日：1999-09-27
申请号：DK94931987
申请日：1994-10-20
Applicant: ABBOTT LAB
Inventor： BAKER WILLIAM R , DONNER B GREGORY , FAKHOURY STEPHEN A , FUNG ANTHONY K L , GARVEY DAVID S , O'CONNOR STEPHEN J , PRASAD RAJNANDAN , ROCKWAY TODD W , ROSENBERG SAUL H , SHEN WANG , STOUT DAVID M , SULLIVAN GERARD M
IPC: C12N9/99 , A61K31/195 , A61K31/215 , A61K31/34 , A61K31/341 , A61K31/357 , A61K31/36 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/41 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61P3/06 , A61P7/00 , A61P9/10 , A61P31/04 , A61P43/00 , C07C69/52 , C07C69/74 , C07C231/02 , C07C233/19 , C07C233/58 , C07C233/59 , C07C233/60 , C07C233/61 , C07C233/62 , C07C233/63 , C07C235/36 , C07C235/40 , C07C237/24 , C07C245/14 , C07C251/42 , C07C259/08 , C07C275/26 , C07C311/51 , C07C323/40 , C07C323/46 , C07C327/20 , C07C327/36 , C07C327/38 , C07D207/325 , C07D213/40 , C07D257/04 , C07D257/06 , C07D263/24 , C07D271/06 , C07D271/10 , C07D277/20 , C07D277/34 , C07D285/16 , C07D285/18 , C07D307/42 , C07D307/52 , C07D309/32 , C07D317/60 , C07D319/06 , C07D333/08 , C07D333/58 , A61K31/16
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公开(公告)号：AU3278993A
公开(公告)日：1993-07-28
申请号：AU3278993
申请日：1992-12-14
Applicant: ABBOTT LAB
Inventor： MEYER MICHAEL D , DEBERNARDIS JOHN F , PRASAD RAJNANDAN , SIPPY KEVIN B , TIETJE KARIN R
IPC: C07D317/58 , A61K31/135 , A61K31/165 , A61K31/352 , A61K31/357 , A61K31/36 , A61K31/382 , A61K31/4035 , A61K31/404 , A61K31/416 , A61K31/4184 , A61K31/423 , A61K31/4245 , A61K31/428 , A61K31/433 , A61K31/47 , A61K31/472 , A61K31/498 , A61K31/538 , A61K31/5415 , A61P9/00 , A61P9/10 , A61P9/12 , A61P25/00 , A61P25/06 , A61P25/18 , A61P25/24 , A61P25/28 , A61P25/30 , A61P27/06 , A61P43/00 , C07C217/58 , C07C217/74 , C07D209/08 , C07D209/14 , C07D209/44 , C07D209/48 , C07D215/12 , C07D217/02 , C07D217/04 , C07D231/56 , C07D235/06 , C07D235/14 , C07D241/42 , C07D263/56 , C07D263/58 , C07D265/36 , C07D271/08 , C07D275/04 , C07D277/64 , C07D277/68 , C07D277/82 , C07D279/02 , C07D279/10 , C07D279/16 , C07D285/14 , C07D307/78 , C07D307/79 , C07D311/58 , C07D311/76 , C07D319/08 , C07D319/18 , C07D327/04 , C07D333/54 , C07D333/58 , C07D333/72 , C07D335/06 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12
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公开(公告)号：CA2125392A1
公开(公告)日：1993-07-08
申请号：CA2125392
申请日：1992-12-14
Applicant: ABBOTT LAB
Inventor： MEYER MICHAEL D , DEBERNARDIS JOHN F , PRASAD RAJNANDAN , SIPPY KEVIN B , TIETJE KARIN R
IPC: C07D317/58 , A61K31/135 , A61K31/165 , A61K31/352 , A61K31/357 , A61K31/36 , A61K31/382 , A61K31/4035 , A61K31/404 , A61K31/416 , A61K31/4184 , A61K31/423 , A61K31/4245 , A61K31/428 , A61K31/433 , A61K31/47 , A61K31/472 , A61K31/498 , A61K31/538 , A61K31/5415 , A61P9/00 , A61P9/10 , A61P9/12 , A61P25/00 , A61P25/06 , A61P25/18 , A61P25/24 , A61P25/28 , A61P25/30 , A61P27/06 , A61P43/00 , C07C217/58 , C07C217/74 , C07D209/08 , C07D209/14 , C07D209/44 , C07D209/48 , C07D215/12 , C07D217/02 , C07D217/04 , C07D231/56 , C07D235/06 , C07D235/14 , C07D241/42 , C07D263/56 , C07D263/58 , C07D265/36 , C07D271/08 , C07D275/04 , C07D277/64 , C07D277/68 , C07D277/82 , C07D279/02 , C07D279/10 , C07D279/16 , C07D285/14 , C07D307/78 , C07D307/79 , C07D311/58 , C07D311/76 , C07D319/08 , C07D319/18 , C07D327/04 , C07D333/54 , C07D333/58 , C07D333/72 , C07D335/06 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D307/81 , A61K31/33 , C07D215/14 , C07D217/16
Abstract: 2125392 9312754 PCTABS00024 The present invention provides an amine compound of formula (I) or a pharmaceutically acceptable salt thereof which is an antagonist for alpha-2 adrenoreceptors and which inhibits serotonin (5-hydroxytryptamine, 5-HT) uptake.
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公开(公告)号：DE69417012T2
公开(公告)日：1999-10-07
申请号：DE69417012
申请日：1994-10-20
Applicant: ABBOTT LAB
Inventor： BAKER WILLIAM , ROCKWAY TODD , DONNER B , SHEN WANG , ROSENBERG SAUL , FAKHOURY STEPHEN , O'CONNOR STEPHEN , STOUT DAVID , FUNG ANTHONY , GARVEY DAVID , PRASAD RAJNANDAN , SULLIVAN GERARD
IPC: C12N9/99 , A61K31/195 , A61K31/215 , A61K31/34 , A61K31/341 , A61K31/357 , A61K31/36 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/41 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61P3/06 , A61P7/00 , A61P9/10 , A61P31/04 , A61P43/00 , C07C69/52 , C07C69/74 , C07C231/02 , C07C233/19 , C07C233/58 , C07C233/59 , C07C233/60 , C07C233/61 , C07C233/62 , C07C233/63 , C07C235/36 , C07C235/40 , C07C237/24 , C07C245/14 , C07C251/42 , C07C259/08 , C07C275/26 , C07C311/51 , C07C323/40 , C07C323/46 , C07C327/20 , C07C327/36 , C07C327/38 , C07D207/325 , C07D213/40 , C07D257/04 , C07D257/06 , C07D263/24 , C07D271/06 , C07D271/10 , C07D277/20 , C07D277/34 , C07D285/16 , C07D285/18 , C07D307/42 , C07D307/52 , C07D309/32 , C07D317/60 , C07D319/06 , C07D333/08 , C07D333/58 , A61K31/16
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公开(公告)号：DE69417012D1
公开(公告)日：1999-04-15
申请号：DE69417012
申请日：1994-10-20
Applicant: ABBOTT LAB
Inventor： BAKER WILLIAM , ROCKWAY TODD , DONNER B , SHEN WANG , ROSENBERG SAUL , FAKHOURY STEPHEN , O'CONNOR STEPHEN , STOUT DAVID , FUNG ANTHONY , GARVEY DAVID , PRASAD RAJNANDAN , SULLIVAN GERARD
IPC: C12N9/99 , A61K31/195 , A61K31/215 , A61K31/34 , A61K31/341 , A61K31/357 , A61K31/36 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/41 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61P3/06 , A61P7/00 , A61P9/10 , A61P31/04 , A61P43/00 , C07C69/52 , C07C69/74 , C07C231/02 , C07C233/19 , C07C233/58 , C07C233/59 , C07C233/60 , C07C233/61 , C07C233/62 , C07C233/63 , C07C235/36 , C07C235/40 , C07C237/24 , C07C245/14 , C07C251/42 , C07C259/08 , C07C275/26 , C07C311/51 , C07C323/40 , C07C323/46 , C07C327/20 , C07C327/36 , C07C327/38 , C07D207/325 , C07D213/40 , C07D257/04 , C07D257/06 , C07D263/24 , C07D271/06 , C07D271/10 , C07D277/20 , C07D277/34 , C07D285/16 , C07D285/18 , C07D307/42 , C07D307/52 , C07D309/32 , C07D317/60 , C07D319/06 , C07D333/08 , C07D333/58 , A61K31/16
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