公开(公告)号：EP0745128A4

公开(公告)日：2000-01-12

申请号：EP94917325

申请日：1994-05-09

Applicant: ABBOTT LAB ,  UNIV GLASGOW

Inventor： CARMAN WILLIAM ,  DECKER RICHARD H ,  WALLACE LESLEY ,  MIMMS LARRY T ,  SOLOMON LARRY R

IPC: G01N33/576 ,  A61K39/00 ,  A61K39/29 ,  A61P31/12 ,  C07K14/02 ,  C07K16/10 ,  C12N5/10 ,  C12N7/00 ,  C12N15/09 ,  C12N15/51 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/577 ,  C07K7/10 ,  C07K13/00 ,  C07K15/06 ,  C12N1/21 ,  C12P21/00

CPC classification number: C07K14/005 ,  A61K39/00 ,  C07K2319/40 ,  C07K2319/61 ,  C12N2730/10122 ,  Y10S435/975 ,  Y10S436/82

公开(公告)号：CA2162132C

公开(公告)日：2001-12-11

申请号：CA2162132

申请日：1994-05-09

Applicant: ABBOTT LAB ,  UNIV GLASGOW

Inventor： CARMAN WILLIAM ,  DECKER RICHARD H ,  WALLACE LESLEY ,  MIMMS LARRY T ,  SOLOMON LARRY R

IPC: G01N33/576 ,  A61K39/00 ,  A61K39/29 ,  A61P31/12 ,  C07K14/02 ,  C07K16/10 ,  C12N5/10 ,  C12N7/00 ,  C12N15/09 ,  C12N15/51 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/577 ,  C07H21/00 ,  C07K19/00 ,  C12N7/04 ,  C07K16/08

Abstract: Mutant Hepatitis B Virus (HBV) nucleic acid sequences useful for a variety o f diagnostic and therapeutic applications, kits for usin g the HBV nucleic acid sequences, HBV immunogenic particles, and a method for producing antibodies to HBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HBV nucleic aci d sequences.

公开(公告)号：AU6908294A

公开(公告)日：1994-12-12

申请号：AU6908294

申请日：1994-05-09

Applicant: ABBOTT LAB ,  UNIV GLASGOW

Inventor： CARMAN WILLIAM ,  DECKER RICHARD H ,  WALLACE LESLEY ,  MIMMS LARRY T ,  SOLOMON LARRY R

IPC: G01N33/576 ,  A61K39/00 ,  A61K39/29 ,  A61P31/12 ,  C07K14/02 ,  C07K16/10 ,  C12N5/10 ,  C12N7/00 ,  C12N15/09 ,  C12N15/51 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/577 ,  C12N1/21 ,  C12P21/00 ,  C07K7/10 ,  C07K13/00 ,  C07K15/06 ,  C07K17/02 ,  G01N33/569

Abstract: Mutant Hepatitis B Virus (HBV) nucleic acid sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HBV nucleic acid sequences, HBV immunogenic particles, and a method for producing antibodies to HBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HBV nucleic acid sequences.

公开(公告)号：ES2212796T3

公开(公告)日：2004-08-01

申请号：ES94917325

申请日：1994-05-09

Applicant: ABBOTT LAB ,  UNIV GLASGOW

Inventor： CARMAN WILLIAM ,  DECKER RICHARD H ,  WALLACE LESLEY ,  MIMMS LARRY T ,  SOLOMON LARRY R

IPC: G01N33/576 ,  A61K39/00 ,  A61K39/29 ,  A61P31/12 ,  C07K14/02 ,  C07K16/10 ,  C12N5/10 ,  C12N7/00 ,  C12N15/09 ,  C12N15/51 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/577 ,  C12N1/21 ,  C12P21/00 ,  C07K14/08

Abstract: Mutant Hepatitis B Virus (HBV) nucleic acid sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HBV nucleic acid sequences, HBV immunogenic particles, and a method for producing antibodies to HBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HBV nucleic acid sequences.

公开(公告)号：DE69433285T2

公开(公告)日：2004-06-24

申请号：DE69433285

申请日：1994-05-09

Applicant: ABBOTT LAB ,  UNIV GLASGOW

Inventor： CARMAN WILLIAM ,  DECKER RICHARD H ,  WALLACE LESLEY ,  MIMMS LARRY T ,  SOLOMON LARRY R

IPC: G01N33/576 ,  A61K39/00 ,  A61K39/29 ,  A61P31/12 ,  C07K14/02 ,  C07K16/10 ,  C12N5/10 ,  C12N7/00 ,  C12N15/09 ,  C12N15/51 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/577 ,  C12N1/21 ,  C12P21/00 ,  C07K14/08

Abstract: Mutant Hepatitis B Virus (HBV) nucleic acid sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HBV nucleic acid sequences, HBV immunogenic particles, and a method for producing antibodies to HBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HBV nucleic acid sequences.

公开(公告)号：CA2162132A1

公开(公告)日：1994-11-24

申请号：CA2162132

申请日：1994-05-09

Applicant: ABBOTT LAB ,  UNIV GLASGOW

Inventor： CARMAN WILLIAM ,  DECKER RICHARD H ,  WALLACE LESLEY ,  MIMMS LARRY T ,  SOLOMON LARRY R

IPC: G01N33/576 ,  A61K39/00 ,  A61K39/29 ,  A61P31/12 ,  C07K14/02 ,  C07K16/10 ,  C12N5/10 ,  C12N7/00 ,  C12N15/09 ,  C12N15/51 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/577 ,  C07H21/00 ,  C07K19/00 ,  C12N7/04 ,  C07K16/08

Abstract: Mutant Hepatitis B Virus (HBV) nucleic acid sequences useful for a variety o f diagnostic and therapeutic applications, kits for usin g the HBV nucleic acid sequences, HBV immunogenic particles, and a method for producing antibodies to HBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HBV nucleic aci d sequences.

公开(公告)号：DE69433285D1

公开(公告)日：2003-12-04

申请号：DE69433285

申请日：1994-05-09

Applicant: ABBOTT LAB ,  UNIV GLASGOW

Inventor： CARMAN WILLIAM ,  DECKER RICHARD H ,  WALLACE LESLEY ,  MIMMS LARRY T ,  SOLOMON LARRY R

IPC: G01N33/576 ,  A61K39/00 ,  A61K39/29 ,  A61P31/12 ,  C07K14/02 ,  C07K16/10 ,  C12N5/10 ,  C12N7/00 ,  C12N15/09 ,  C12N15/51 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/577 ,  C12N1/21 ,  C12P21/00 ,  C07K14/08

Abstract: Mutant Hepatitis B Virus (HBV) nucleic acid sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HBV nucleic acid sequences, HBV immunogenic particles, and a method for producing antibodies to HBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HBV nucleic acid sequences.

公开(公告)号：CA2365300A1

公开(公告)日：2000-09-21

申请号：CA2365300

申请日：2000-03-01

Applicant: ABBOTT LAB

Inventor： BUKO ALEXANDER M ,  TANG QING ,  LADROR URI S ,  SOLOMON LARRY R ,  HOLZMAN THOMAS F ,  HARLAN JOHN E ,  EGAN DAVID A

IPC: G01N33/50 ,  C12Q1/02 ,  C12Q1/68 ,  C12Q1/70 ,  C40B30/00 ,  C40B40/02 ,  C40B50/06 ,  G01N33/15 ,  G01N33/53 ,  G01N33/567

Abstract: Centrifugation is used to induce and/or enhance binding between macromolecul ar targets and either small-molecule ligands or larger biomolecules as single entities or mixtures. With the enhanced binding, the method of the invention permits detection of ligands that bind to target substances and improve the design of ligands. The process relies on centrifugal force to establish a differential and selective concentration gradient between macromolecular therapeutic targets and the desired ligands. Once formed, the information about the self-sorting binding events is derived by analyzing the differenti al gradient of macromolecules and ligands in situ or by fractionating the gradient into individual samples for independent analysis. A variety of methods or combinations thereof, can be used to look for enhanced levels of bound ligands.