公开(公告)号：WO9955901A3

公开(公告)日：2000-04-20

申请号：PCT/US9908923

申请日：1999-04-23

Applicant: ABBOTT LAB

Inventor： VANBIESEN TIM ,  JARVIS MICHAEL F ,  LYNCH KEVIN J ,  METZGER RANDY E ,  BURGARD EDWARD C

IPC: C07K14/705 ,  G01N33/566 ,  G01N33/50

CPC classification number: C07K14/705 ,  G01N33/566 ,  G01N2500/00

Abstract: A method of screening candidate compounds for their ability to modulate expression of human purinoreceptors is provided. The method relates to the use of stably transfected cell lines that express human or other mammalian purinoreceptors to identify purinoreceptor ligands, and to determine the amount of a receptor agonist or antagonist in a test sample.

Abstract translation: 提供了筛选候选化合物调节人类嘌呤受体表达能力的方法。 该方法涉及使用稳定转染的细胞系，其表达人或其他哺乳动物嘌呤受体以鉴定嘌呤受体配体，并确定测试样品中受体激动剂或拮抗剂的量。