公开(公告)号：WO0011167A3

公开(公告)日：2000-10-05

申请号：PCT/US9919042

申请日：1999-08-20

Applicant: ABBOTT LAB

Inventor： LYNCH KEVIN J ,  BURGARD EDWARD C ,  METZGER RANDY E ,  NIFORATOS WENDE ,  TOUMA EDWARD B

IPC: G01N33/50 ,  A61K38/00 ,  A61K45/00 ,  A61P1/00 ,  A61P25/00 ,  A61P25/04 ,  A61P27/16 ,  C07K14/705 ,  C07K16/28 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  C12R1/91 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  G01N33/577 ,  G01N33/68

CPC classification number: C07K14/705 ,  A61K38/00

Abstract: A human P2X2 purinergic receptor polypeptide is provided. Nucleic acid molecules encoding the human P2X2 receptor polypeptide, and vectors and host cells containing such nucleic acid molecules, are also provided. In addition, methods are provided for producing the P2X2 receptor polypeptide, as are methods of using such polypeptides and host cells that express the same to screen for compounds having activity on P2X2 receptor. Further, therapeutic uses involving aspects of this receptor are contemplated.

Abstract translation: 提供人P2X2嘌呤能受体多肽。 还提供了编码人P2X2受体多肽的核酸分子，以及含有该核酸分子的载体和宿主细胞。 此外，还提供了用于产生P2X2受体多肽的方法，使用这些多肽的方法和表达相同的宿主细胞来筛选具有P2X2受体活性的化合物。 此外，涉及涉及该受体的方面的治疗用途。

公开(公告)号：WO0063379A3

公开(公告)日：2001-11-15

申请号：PCT/US0010919

申请日：2000-04-21

Applicant: ABBOTT LAB

Inventor： JARVIS MICHAEL F ,  LYNCH KEVIN J ,  BURGARD EDWARD C ,  VANBIESEN TIMOTHY ,  KOWALUK ELIZABETH A

IPC: G01N33/53 ,  A61K31/16 ,  A61K31/185 ,  A61K31/675 ,  A61K31/7076 ,  A61K38/00 ,  A61K45/00 ,  A61P25/04 ,  A61P29/02 ,  A61P43/00 ,  C07K14/705 ,  C07K16/28 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  C12R1/91 ,  G01N33/566

CPC classification number: C07K14/705 ,  A61K31/16 ,  A61K31/185 ,  A61K38/00

Abstract: The subject invention relates to the P2X3 receptor, methods of modulating the activity of the P2X3 receptor and to uses of these methods. In particular, such methods may be used, for example, to accelerate the rate of resensitization of a desensitized receptor.

Abstract translation: 本发明涉及P2X3受体，调节P2X3受体活性的方法和这些方法的用途。 特别地，这些方法可以用于例如加速脱敏受体的再吸收速率。

公开(公告)号：WO9955901A3

公开(公告)日：2000-04-20

申请号：PCT/US9908923

申请日：1999-04-23

Applicant: ABBOTT LAB

Inventor： VANBIESEN TIM ,  JARVIS MICHAEL F ,  LYNCH KEVIN J ,  METZGER RANDY E ,  BURGARD EDWARD C

IPC: C07K14/705 ,  G01N33/566 ,  G01N33/50

CPC classification number: C07K14/705 ,  G01N33/566 ,  G01N2500/00

Abstract: A method of screening candidate compounds for their ability to modulate expression of human purinoreceptors is provided. The method relates to the use of stably transfected cell lines that express human or other mammalian purinoreceptors to identify purinoreceptor ligands, and to determine the amount of a receptor agonist or antagonist in a test sample.

Abstract translation: 提供了筛选候选化合物调节人类嘌呤受体表达能力的方法。 该方法涉及使用稳定转染的细胞系，其表达人或其他哺乳动物嘌呤受体以鉴定嘌呤受体配体，并确定测试样品中受体激动剂或拮抗剂的量。

公开(公告)号：CA2339871A1

公开(公告)日：2000-03-02

申请号：CA2339871

申请日：1999-08-20

Applicant: ABBOTT LAB

Inventor： LYNCH KEVIN J ,  METZGER RANDY E ,  NIFORATOS WENDE ,  BURGARD EDWARD C ,  TOUMA EDWARD B

IPC: G01N33/50 ,  A61K38/00 ,  A61K45/00 ,  A61P1/00 ,  A61P25/00 ,  A61P25/04 ,  A61P27/16 ,  C07K14/705 ,  C07K16/28 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  C12R1/91 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  G01N33/577 ,  A61P5/00 ,  A61P43/00 ,  G01N33/68

Abstract: A human P2X2 purinergic receptor polypeptide is provided. Nucleic acid molecules encoding the human P2X2 receptor polypeptide, and vectors and host cells containing such nucleic acid molecules, are also provided. In addition , methods are provided for producing the P2X2 receptor polypeptide, as are methods of using such polypeptides and host cells that express the same to screen for compounds having activity on P2X2 receptor. Further, therapeutic uses involving aspects of this receptor are contemplated.

公开(公告)号：CA2317449A1

公开(公告)日：1999-07-22

申请号：CA2317449

申请日：1999-01-15

Applicant: ABBOTT LAB

Inventor： VAN BIESEN TIM ,  LYNCH KEVIN J ,  BURGARD EDWARD C

IPC: C07K14/705 ,  C12N15/12 ,  C07K16/28 ,  C12Q1/68 ,  G01N33/566

Abstract: A human P2X3 purinergic receptor polypeptide is provided. Nucleic acid molecules encoding the human P2X3 receptor polypeptide, and vectors and host cells containing such nucleic acid molecules, are also provided. In addition, methods are provided for producing the P2X3 receptor polypeptide, as are methods of using such polypeptides and host cells that express the same to screen for compounds having activity at the P2X3 receptor.

公开(公告)号：CA2370659A1

公开(公告)日：2000-10-26

申请号：CA2370659

申请日：2000-04-21

Applicant: ABBOTT LAB

Inventor： LYNCH KEVIN J ,  BURGARD EDWARD C ,  JARVIS MICHAEL F ,  VAN BIESEN TIMOTHY ,  KOWALUK ELIZABETH A

IPC: G01N33/53 ,  A61K31/16 ,  A61K31/185 ,  A61K31/675 ,  A61K31/7076 ,  A61K38/00 ,  A61K45/00 ,  A61P25/04 ,  A61P29/02 ,  A61P43/00 ,  C07K14/705 ,  C07K16/28 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  C12R1/91 ,  G01N33/566

Abstract: The subject invention relates to the P2X3 receptor, methods of modulating th e activity of the P2X3 receptor and to uses of these methods. In particular, such methods may be used, for example, to accelerate the rate of resensitization of a desensitized receptor.