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公开(公告)号：WO2011005893A2
公开(公告)日：2011-01-13
申请号：PCT/US2010041257
申请日：2010-07-07
Applicant: ABBOTT LAB , DEVANARAYAN VISWANATH , PATTERSON MELANIE JOY , WARING JEFFREY F , WITTE DAVID
Inventor： DEVANARAYAN VISWANATH , PATTERSON MELANIE JOY , WARING JEFFREY F , WITTE DAVID
CPC classification number: G01N33/6896 , G01N2800/2821 , G01N2800/60
Abstract: Methods for classifying a test sample as indicative of Alzheimer's disease use protein and peptide biomarkers that are differentially expressed in the cerebral spinal fluid (CSF) of subjects with Alzheimer's disease relative to age-matched controls. The methods also use protein and peptide signatures indicative of Alzheimer's disease. Microarrays and kits for detecting the protein and peptide biomarkers in CSF samples can be used to classify Alzheimer's disease state from test samples.
Abstract translation: 用于将测试样品分类为指示阿尔茨海默病使用蛋白质和肽相对于年龄匹配的对照在阿尔茨海默病受试者的脑脊液（CSF）中差异表达的肽生物标志物的方法。 该方法还使用指示阿尔茨海默病的蛋白质和肽特征。 用于检测CSF样品中蛋白质和肽生物标志物的微阵列和试剂盒可用于从测试样品中分类阿尔茨海默病状态。
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公开(公告)号：WO2011005893A3
公开(公告)日：2011-06-16
申请号：PCT/US2010041257
申请日：2010-07-07
Applicant: ABBOTT LAB , DEVANARAYAN VISWANATH , PATTERSON MELANIE JOY , WARING JEFFREY F , WITTE DAVID
Inventor： DEVANARAYAN VISWANATH , PATTERSON MELANIE JOY , WARING JEFFREY F , WITTE DAVID
CPC classification number: G01N33/6896 , G01N2800/2821 , G01N2800/60
Abstract: Methods for classifying a test sample as indicative of Alzheimer's disease use protein and peptide biomarkers that are differentially expressed in the cerebral spinal fluid (CSF) of subjects with Alzheimer's disease relative to age-matched controls. The methods also use protein and peptide signatures indicative of Alzheimer's disease. Microarrays and kits for detecting the protein and peptide biomarkers in CSF samples can be used to classify Alzheimer's disease state from test samples.
Abstract translation: 将测试样品分类为阿尔茨海默氏病指示的方法使用蛋白质和肽生物标志物，其相对于年龄匹配对照在阿尔茨海默氏病患者的脑脊髓液（CSF）中差异表达。 该方法还使用指示阿尔茨海默病的蛋白质和肽标志。 用于检测CSF样品中的蛋白质和肽生物标志物的微阵列和试剂盒可用于从测试样品分类阿尔茨海默病状态。
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公开(公告)号：CA2517831A1
公开(公告)日：2004-10-07
申请号：CA2517831
申请日：2004-03-19
Applicant: ABBOTT LAB
Inventor： KEMPF DALE J , BERTZ RICHARD J , WARING JEFFREY F
IPC: A61K31/426 , A61K38/21 , A61P1/16 , A61K38/55
Abstract: The present invention is directed to a method for inducing UGT1A1 isoform expression for treatment of a disease, disorder or adverse effect caused by an elevated serum concentration of an UGT1A1 substrate comprising the step of administering to a subject an effective amount of ritonavir. In particular, the present invention is directed to a method of treating unconjugated hyperbilirubinemia by UGT1A1 induction comprising the step of administering to a subject an effective amount of ritonavir.
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