公开(公告)号：AU688946B2

公开(公告)日：1998-03-19

申请号：AU3104795

申请日：1995-03-01

Applicant: ABBOTT LAB

Inventor： KLEIN LARRY L ,  YEUNG CLINTON M

IPC: A61K31/335 ,  A61K31/337 ,  A61P35/00 ,  C07D305/14 ,  C07D493/06

Abstract: Compounds having the formula (I) wherein -OR1 comprises alkanoyl or the C-13 side-chain of taxol; R2, R3, and R6 can be oxygenated or hydrogen in various combinations; and R4 and R5 are acyl groups, as well as a process for the preparation thereof, pharmaceutical compositions containing the above compounds, and a method for their use in inhibiting tumor growth.

公开(公告)号：PT749432E

公开(公告)日：2001-09-28

申请号：PT95912007

申请日：1995-03-01

Applicant: ABBOTT LAB

Inventor： KLEIN LARRY L ,  YEUNG CLINTON M ,  LI LEPING

IPC: A61K31/335 ,  A61K31/337 ,  A61P35/00 ,  C07D305/14 ,  C07D493/06

Abstract: Compounds having the formula (I) wherein -OR1 comprises alkanoyl or the C-13 side-chain of taxol; R2, R3, and R6 can be oxygenated or hydrogen in various combinations; and R4 and R5 are acyl groups, as well as a process for the preparation thereof, pharmaceutical compositions containing the above compounds, and a method for their use in inhibiting tumor growth.

公开(公告)号：PH31271A

公开(公告)日：1998-06-18

申请号：PH50096

申请日：1995-03-09

Applicant: ABBOTT LAB

Inventor： KLEIN LARRY L ,  YEUNG CLINTON M ,  LEPING LI

IPC: A61K31/335 ,  A61K31/337 ,  A61P35/00 ,  C07D305/14 ,  C07D493/06

Abstract: Compounds having the formula (I) wherein -OR1 comprises alkanoyl or the C-13 side-chain of taxol; R2, R3, and R6 can be oxygenated or hydrogen in various combinations; and R4 and R5 are acyl groups, as well as a process for the preparation thereof, pharmaceutical compositions containing the above compounds, and a method for their use in inhibiting tumor growth.

公开(公告)号：AU3104795A

公开(公告)日：1995-09-25

申请号：AU3104795

申请日：1995-03-01

Applicant: ABBOTT LAB

Inventor： KLEIN LARRY L ,  YEUNG CLINTON M

IPC: A61K31/335 ,  A61K31/337 ,  A61P35/00 ,  C07D305/14 ,  C07D493/06

Abstract: Compounds having the formula (I) wherein -OR1 comprises alkanoyl or the C-13 side-chain of taxol; R2, R3, and R6 can be oxygenated or hydrogen in various combinations; and R4 and R5 are acyl groups, as well as a process for the preparation thereof, pharmaceutical compositions containing the above compounds, and a method for their use in inhibiting tumor growth.

公开(公告)号：AU623764B2

公开(公告)日：1992-05-21

申请号：AU5402890

申请日：1990-03-28

Applicant: ABBOTT LAB

Inventor： FREIBERG LESLIE A ,  KLEIN LARRY L ,  YEUNG CLINTON M ,  EDWARDS CARLA M ,  BACINO DAVID J

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  A61K31/71 ,  A61K31/365

Abstract: PCT No. PCT/US90/01658 Sec. 371 Date Aug. 21, 1991 Sec. 102(e) Date Aug. 21, 1991 PCT Filed Mar. 28, 1990.New 9-deoxo-9,12-epoxy erythromycin derivatives are disclosed which have improved antibacterial properties. Compositions comprising the erythromycin derivatives and methods of treating mammalian patients with the erythromycin derivatives are also disclosed.

公开(公告)号：AU5402890A

公开(公告)日：1990-10-22

申请号：AU5402890

申请日：1990-03-28

Applicant: ABBOTT LAB

Inventor： FREIBERG LESLIE A ,  KLEIN LARRY L ,  YEUNG CLINTON M ,  EDWARDS CARLA M ,  BACINO DAVID J

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

Abstract: PCT No. PCT/US90/01658 Sec. 371 Date Aug. 21, 1991 Sec. 102(e) Date Aug. 21, 1991 PCT Filed Mar. 28, 1990.New 9-deoxo-9,12-epoxy erythromycin derivatives are disclosed which have improved antibacterial properties. Compositions comprising the erythromycin derivatives and methods of treating mammalian patients with the erythromycin derivatives are also disclosed.

公开(公告)号：CA2049359A1

公开(公告)日：1990-09-29

申请号：CA2049359

申请日：1990-03-28

Applicant: ABBOTT LAB

Inventor： FREIBERG LESLIE A ,  KLEIN LARRY L ,  YEUNG CLINTON M ,  EDWARDS CARLA M ,  BACINO DAVID J

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  C07H23/00 ,  A61K31/71

Abstract: 2049359 9011288 PCTABS00002 New 9-deoxo-9,12-epoxy erythromycin derivatives are disclosed which have improved antibacterial properties. Compositions comprising the erythromycin derivatives and methods of treating mammalian patients with the erythromycin derivatives are also disclosed.

公开(公告)号：ES2158093T3

公开(公告)日：2001-09-01

申请号：ES95912007

申请日：1995-03-01

Applicant: ABBOTT LAB

Inventor： KLEIN LARRY L ,  YEUNG CLINTON M ,  LI LEPING

IPC: A61K31/335 ,  A61K31/337 ,  A61P35/00 ,  C07D305/14 ,  C07D493/06

Abstract: Compounds having the formula (I) wherein -OR1 comprises alkanoyl or the C-13 side-chain of taxol; R2, R3, and R6 can be oxygenated or hydrogen in various combinations; and R4 and R5 are acyl groups, as well as a process for the preparation thereof, pharmaceutical compositions containing the above compounds, and a method for their use in inhibiting tumor growth.

公开(公告)号：DK0749432T3

公开(公告)日：2001-07-30

申请号：DK95912007

申请日：1995-03-01

Applicant: ABBOTT LAB

Inventor： KLEIN LARRY L ,  YEUNG CLINTON M ,  LI LEPING

IPC: A61K31/335 ,  A61K31/337 ,  A61P35/00 ,  C07D305/14 ,  C07D493/06

Abstract: Compounds having the formula (I) wherein -OR1 comprises alkanoyl or the C-13 side-chain of taxol; R2, R3, and R6 can be oxygenated or hydrogen in various combinations; and R4 and R5 are acyl groups, as well as a process for the preparation thereof, pharmaceutical compositions containing the above compounds, and a method for their use in inhibiting tumor growth.

公开(公告)号：AT201019T

公开(公告)日：2001-05-15

申请号：AT95912007

申请日：1995-03-01

Applicant: ABBOTT LAB

Inventor： KLEIN LARRY L ,  YEUNG CLINTON M ,  LI LEPING

IPC: A61K31/335 ,  A61K31/337 ,  A61P35/00 ,  C07D305/14 ,  C07D493/06

Abstract: Compounds having the formula (I) wherein -OR1 comprises alkanoyl or the C-13 side-chain of taxol; R2, R3, and R6 can be oxygenated or hydrogen in various combinations; and R4 and R5 are acyl groups, as well as a process for the preparation thereof, pharmaceutical compositions containing the above compounds, and a method for their use in inhibiting tumor growth.