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1.发明申请
公开(公告)号：WO2011119345A3
公开(公告)日：2011-09-29
申请号：PCT/US2011/027895
申请日：2011-03-10
Applicant: ABBOTT LABORATORIES , DING, Hong , ELMORE, Steven , HEXAMER, Laura , KUNZER, Aaron, R. , PARK, Cheol-Min , SOUERS, Andrew, J. , SULLIVAN, Gerard , WENDT, Michael
Inventor： DING, Hong , ELMORE, Steven , HEXAMER, Laura , KUNZER, Aaron, R. , PARK, Cheol-Min , SOUERS, Andrew, J. , SULLIVAN, Gerard , WENDT, Michael
IPC: C07D295/112 , C07D295/195 , C07D417/04 , C07D211/58 , C07C311/51 , A61K31/451 , A61K31/495 , A61K31/18 , A61P35/00
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti apoptotic Bcl-2 protein.
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公开(公告)号：WO2012071374A1
公开(公告)日：2012-05-31
申请号：PCT/US2011/061769
申请日：2011-11-22
Applicant: ABBOTT LABORATORIES , ELMORE, Steven , SOUERS, Andrew , WANG, Li Chun , GHAYUR, Tariq , PERPER, Stuart J.
Inventor： ELMORE, Steven , SOUERS, Andrew , WANG, Li Chun , GHAYUR, Tariq , PERPER, Stuart J.
IPC: A61K31/496 , A61P37/00
CPC classification number: A61K31/5377 , A61K31/496
Abstract: This invention pertains to methods of treating systemic lupus erythematosus, lupus nephritis or Sjogren's Syndrome with compounds that selectively inhibit the activity of Bcl 2 anti apoptotic proteins. Specifically, the current invention is directed to treatment with compounds that selectively inhibit the activity of Bcl-2 proteins, with a lesser affinity for inhibiting the activity of other BCL-2 family proteins, including Bcl- x L .
Abstract translation: 本发明涉及用选择性抑制Bcl 2抗凋亡蛋白活性的化合物治疗系统性红斑狼疮，狼疮肾炎或干燥综合征的方法。 具体地，本发明涉及用选择性抑制Bcl-2蛋白活性的化合物治疗，对抑制其它BCL-2家族蛋白（包括Bcl-xL）活性的亲和性较小。
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公开(公告)号：WO2005049594A1
公开(公告)日：2005-06-02
申请号：PCT/US2004/037911
申请日：2004-11-12
Applicant: ABBOTT LABORATORIES , BRUNCKO, Milan , DING, Hong , ELMORE, Steven , KUNZER, Aaron R. , LYNCH, Christopher L. , MCCLELLAN, William , PARK, Cheol-Min , PETROS, Andrew , SONG, Xiaohong , WANG, Xilu , TU, Noah , WENDT, Michael D.
Inventor： BRUNCKO, Milan , DING, Hong , ELMORE, Steven , KUNZER, Aaron R. , LYNCH, Christopher L. , MCCLELLAN, William , PARK, Cheol-Min , PETROS, Andrew , SONG, Xiaohong , WANG, Xilu , TU, Noah , WENDT, Michael D.
IPC: C07D295/14
CPC classification number: C07D277/74 , C04B35/632 , C07C323/25 , C07C2601/16 , C07D205/04 , C07D207/16 , C07D211/46 , C07D211/60 , C07D211/74 , C07D213/70 , C07D213/75 , C07D233/06 , C07D233/84 , C07D239/06 , C07D263/58 , C07D277/36 , C07D295/13 , C07D295/192 , C07D307/64 , C07D335/02 , C07D401/12 , C07D403/04 , C07D409/12 , C07D487/04 , C07D487/08
Abstract: Disclosed are N-acylsulfonamide compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression of one or more than one anti-apoptotic protein family member.
Abstract translation: 公开了抑制抗凋亡蛋白家族成员的活性的N-酰基磺酰胺化合物，含有该化合物的组合物和该化合物用于制备用于治疗疾病的药物的用途，其中发生一种或多种抗凋亡蛋白家族成员的表达。
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4.发明申请APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 审中-公开细胞凋亡诱导剂治疗癌症和免疫及自身免疫疾病
公开(公告)号：WO2010138588A2
公开(公告)日：2010-12-02
申请号：PCT/US2010/036198
申请日：2010-05-26
Applicant: ABBOTT LABORATORIES , BRUNCKO, Milan , DING, Hong , DOHERTY, George , ELMORE, Steven , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron R. , SONG, Xiaohong , SOUERS, Andrew J. , SULLIVAN, Gerard , TAO, Zhi-Fu , WANG, Gary T. , WANG, Le , WANG, Xilu , WENDT, Michael , MANTEI, Robert , HANSEN, Todd M.
Inventor： BRUNCKO, Milan , DING, Hong , DOHERTY, George , ELMORE, Steven , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron R. , SONG, Xiaohong , SOUERS, Andrew J. , SULLIVAN, Gerard , TAO, Zhi-Fu , WANG, Gary T. , WANG, Le , WANG, Xilu , WENDT, Michael , MANTEI, Robert , HANSEN, Todd M.
IPC: C07D471/04
CPC classification number: C07D471/04 , C07D491/052 , C07D519/00
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
Abstract translation: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有该化合物的组合物和治疗表达抗凋亡Bcl-2蛋白的疾病的方法。
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5.发明申请
公开(公告)号：WO2011149492A1
公开(公告)日：2011-12-01
申请号：PCT/US2010/057587
申请日：2010-11-22
Applicant: ABBOTT LABORATORIES , BRUNCKO, Milan , DING, Hong , DOHERTY, George , ELMORE, Steven , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron R. , SONG, Xiaohong , SOUERS, Andrew, J. , SULLIVAN, Gerard , TAO, Zhi-Fu , WANG, Gary, T. , WANG, Le , WANG, Xilu , WENDT, Michael , MANTEI, Robert , HANSEN, Todd, M.
Inventor： BRUNCKO, Milan , DING, Hong , DOHERTY, George , ELMORE, Steven , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron R. , SONG, Xiaohong , SOUERS, Andrew, J. , SULLIVAN, Gerard , TAO, Zhi-Fu , WANG, Gary, T. , WANG, Le , WANG, Xilu , WENDT, Michael , MANTEI, Robert , HANSEN, Todd, M.
IPC: C07D471/04 , A61K31/437 , A61K35/00
CPC classification number: C07D401/12 , A61K31/496 , C07D209/82 , C07D401/14 , C07D403/12 , C07D471/04 , C07D519/00 , Y02A50/463
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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Patent Agency Ranking
公开(公告)号：WO2006127364A1
公开(公告)日：2006-11-30
申请号：PCT/US2006/019132
申请日：2006-05-17
Applicant: ABBOTT LABORATORIES , ELMORE, Steven , LYNCH, Christopher , WANG, Xilu
Inventor： ELMORE, Steven , LYNCH, Christopher , WANG, Xilu
IPC: C07D273/00 , C07D413/12 , A61K31/395 , A61P35/00
CPC classification number: C07D273/02 , C07D273/00 , C07D413/12
Abstract: Compounds of formula (I), in which B 1 and X 1 are together alkylene which is unsubstituted or substituted with =O and having one CH2 moiety unreplaced or replaced with CH=CH, O, NH or N(alkyl), which inhibit the activity of antiapoptotic Bcl-2 family protein members, compositions containing the compounds and methods of treating diseases during which are expressed one or more than one of an anti-apoptotic family protein member are disclosed.
Abstract translation: 其中B 1和X 2的式（I）化合物在一起是未被取代或被= O取代且具有一个CH2部分的亚烷基未置换或被CH = CH，O，NH或N（烷基），其抑制抗凋亡Bcl-2家族蛋白成员的活性，含有该化合物的组合物和治疗疾病的方法，其中表达一种或多种抗凋亡家族蛋白成员 被披露。
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公开(公告)号：WO2005049593A2
公开(公告)日：2005-06-02
申请号：PCT/US2004/036770
申请日：2004-11-03
Applicant: ABBOTT LABORATORIES , BRUNCKO, Milan , ELMORE, Steven , KUNZER, Aaron, R. , LYNCH, Christopher, L. , WANG, Xilu , WENDT, Michael, D.
Inventor： BRUNCKO, Milan , ELMORE, Steven , KUNZER, Aaron, R. , LYNCH, Christopher, L. , WANG, Xilu , WENDT, Michael, D.
IPC: C07D295/14
CPC classification number: C07D277/74 , C04B35/632 , C07C323/25 , C07C2601/16 , C07D205/04 , C07D207/16 , C07D211/46 , C07D211/60 , C07D211/74 , C07D213/70 , C07D213/75 , C07D233/06 , C07D233/84 , C07D239/06 , C07D263/58 , C07D277/36 , C07D295/13 , C07D295/192 , C07D307/64 , C07D335/02 , C07D401/12 , C07D403/04 , C07D409/12 , C07D487/04 , C07D487/08
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which are expressed one or more than one of an anti apoptotic protein family member.
Abstract translation: 公开了抑制抗凋亡蛋白质家族成员的活性的化合物，含有该化合物的组合物和该化合物用于制备用于治疗疾病的药物的用途，在该疾病期间表达一种或多种抗 - 凋亡蛋白家族成员。
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公开(公告)号：EP1888543B1
公开(公告)日：2012-08-01
申请号：EP06760042.9
申请日：2006-05-17
Applicant: ABBOTT LABORATORIES
Inventor： ELMORE, Steven , LYNCH, Christopher , WANG, Xilu
IPC: C07D273/00 , C07D273/02 , C07D413/12 , A61K31/395 , A61P35/00
CPC classification number: C07D273/02 , C07D273/00 , C07D413/12
Abstract: Compounds of formula (I), in which B1 and X1 are together alkylene which is unsubstituted or substituted with =O and having one CH2 moiety unreplaced or replaced with CH=CH, O, NH or N(alkyl), which inhibit the activity of antiapoptotic Bcl-2 family protein members, compositions containing the compounds and methods of treating diseases during which are expressed one or more than one of an anti-apoptotic family protein member are disclosed.
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公开(公告)号：EP1888543A1
公开(公告)日：2008-02-20
申请号：EP06760042.9
申请日：2006-05-17
Applicant: ABBOTT LABORATORIES
Inventor： ELMORE, Steven , LYNCH, Christopher , WANG, Xilu
IPC: C07D273/00 , C07D413/12 , A61K31/395 , A61P35/00
CPC classification number: C07D273/02 , C07D273/00 , C07D413/12
Abstract: Compounds of formula (I), in which B1 and X1 are together alkylene which is unsubstituted or substituted with =O and having one CH2 moiety unreplaced or replaced with CH=CH, O, NH or N(alkyl), which inhibit the activity of antiapoptotic Bcl-2 family protein members, compositions containing the compounds and methods of treating diseases during which are expressed one or more than one of an anti-apoptotic family protein member are disclosed.
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10.发明公开
公开(公告)号：EP1685119A1
公开(公告)日：2006-08-02
申请号：EP04810896.3
申请日：2004-11-12
Applicant: ABBOTT LABORATORIES
Inventor： BRUNCKO, Milan , DING, Hong , ELMORE, Steven , KUNZER, Aaron R. , LYNCH, Christopher L. , MCCLELLAN, William , PARK, Cheol-Min , PETROS, Andrew , SONG, Xiaohong , WANG, Xilu , TU, Noah , WENDT, Michael D.
IPC: C07D295/14 , A61K31/635 , A61P35/00 , C07D413/12 , C07D403/12 , C07D211/44 , C07C311/51
CPC classification number: C07D277/74 , C04B35/632 , C07C323/25 , C07C2601/16 , C07D205/04 , C07D207/16 , C07D211/46 , C07D211/60 , C07D211/74 , C07D213/70 , C07D213/75 , C07D233/06 , C07D233/84 , C07D239/06 , C07D263/58 , C07D277/36 , C07D295/13 , C07D295/192 , C07D307/64 , C07D335/02 , C07D401/12 , C07D403/04 , C07D409/12 , C07D487/04 , C07D487/08
Abstract: Disclosed are N-acylsulfonamide compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression of one or more than one anti-apoptotic protein family member.
Abstract translation: 公开了抑制抗凋亡蛋白家族成员的活性的N-酰基磺酰胺化合物，含有该化合物的组合物和该化合物用于制备用于治疗疾病的药物的用途，其中发生一种或多种抗凋亡蛋白家族成员的表达。
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