公开(公告)号：WO2014152610A1

公开(公告)日：2014-09-25

申请号：PCT/US2014/027528

申请日：2014-03-14

Applicant: ABBOTT LABORATORIES

Inventor： PEREIRA, Suzette ,  LUO, Menghua ,  EDENS, Neile ,  DAVIS, Gerard ,  GAWEL, Susan

IPC: G01N33/68

CPC classification number: G01N33/6887 ,  A61K31/19 ,  A61K31/198 ,  G01N2333/775 ,  G01N2333/8146 ,  G01N2333/96494 ,  G01N2800/50 ,  G01N2800/52 ,  A61K2300/00

Abstract: Biomarkers and related methods of using the biomarkers to identify subjects at risk of losing lean body mass during a prolonged period of physical inactivity are provided. The biomarkers may be blood biomarkers and include Tissue Inhibitor of Metalloprotease-1 (TIMP-1), Tenascin C (TNC), and Apolipoprotein A2 (ApoA-2). Also provided is a method of treating subjects at risk of losing lean body mass during a prolonged period of physical inactivity.

Abstract translation: 提供了生物标志物和相关方法，使用生物标志物来识别在长时间身体活动期间失去瘦体重的风险的受试者。 生物标志物可以是血液生物标志物，包括金属蛋白酶-1（TIMP-1），腱生蛋白C（TNC）和载脂蛋白A2（ApoA-2）的组织抑制剂。 还提供了一种治疗在长时间身体不活动期间失去瘦体重的风险的受试者的方法。

公开(公告)号：WO2014152606A2

公开(公告)日：2014-09-25

申请号：PCT/US2014/027524

申请日：2014-03-14

Applicant: ABBOTT LABORATORIES

Inventor： LUO, Menghua ,  PEREIRA, Suzette ,  EDENS, Neile ,  DAVIS, Gerard ,  GAWEL, Susan ,  CHANDRAN, Raj

IPC: A61K31/19

CPC classification number: A61K31/19 ,  G01N33/6893 ,  G01N2333/47 ,  G01N2333/4704 ,  G01N2333/575 ,  G01N2800/52

Abstract: Insulin resistance biomarkers and related methods of using the biomarkers are provided. The biomarkers may be blood biomarkers and include C-peptide, Insulin-Like Growth Factor- Binding Protein 2 (IGFBP-2), and Leptin. Also provided is a method of reducing the effect of prolonged physical inactivity on insulin resistance in a subject who is experiencing prolonged physical inactivity, or who is expected to experience prolonged physical inactivity in the near future.

Abstract translation: 提供了使用生物标志物的胰岛素抵抗生物标志物和相关方法。 生物标志物可以是血液生物标志物，包括C肽，胰岛素样生长因子结合蛋白2（IGFBP-2）和瘦蛋白。 还提供了一种减少长期身体不活动对经历长时间身体不活动的受试者或预期在不久的将来会经历长时间身体不活动的受试者的胰岛素抵抗的影响的方法。

公开(公告)号：EP2968236A2

公开(公告)日：2016-01-20

申请号：EP14719475.7

申请日：2014-03-14

Applicant: ABBOTT LABORATORIES

Inventor： LUO, Menghua ,  PEREIRA, Suzette ,  EDENS, Neile ,  DAVIS, Gerard ,  GAWEL, Susan ,  CHANDRAN, Raj

IPC: A61K31/19 ,  A61P3/10

CPC classification number: A61K31/19 ,  G01N33/6893 ,  G01N2333/47 ,  G01N2333/4704 ,  G01N2333/575 ,  G01N2800/52

Abstract: Insulin resistance biomarkers and related methods of using the biomarkers are provided. The biomarkers may be blood biomarkers and include C-peptide, Insulin-Like Growth Factor- Binding Protein 2 (IGFBP-2), and Leptin. Also provided is a method of reducing the effect of prolonged physical inactivity on insulin resistance in a subject who is experiencing prolonged physical inactivity, or who is expected to experience prolonged physical inactivity in the near future.