公开(公告)号：WO2019112860A1

公开(公告)日：2019-06-13

申请号：PCT/US2018/062888

申请日：2018-11-28

Applicant: ABBOTT LABORATORIES

Inventor： MCQUISTON, Beth ,  DATWYLER, Saul ,  CHANDRAN, Raj ,  MARINO, Jaime

IPC: G01N33/68

Abstract: Disclosed herein are methods of aiding in the diagnosis and evaluation of a subject that has sustained or may have sustained an injury to the head. For example, the present disclosure provides methods for aiding in the diagnosis and evaluation of a subject to determine whether the subject has sustained a traumatic brain injury (TBI) by detecting or measuring a combination of the levels of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) in samples taken at various time points within 48 hours after the subject has sustained or may have sustained an injury to the head.

公开(公告)号：WO2019113525A3

公开(公告)日：2019-06-13

申请号：PCT/US2018/064587

申请日：2018-12-07

Applicant: ABBOTT LABORATORIES

Inventor： MCQUISTON, Beth ,  DATWYLER, Saul ,  CHANDRAN, Raj

IPC: G01N33/68

Abstract: Disclosed herein are methods, and kits for use in said methods, that aid in the diagnosis and evaluation of a subject that has sustained an orthopedic injury and sustained or may have sustained an injury to the head, such as mild traumatic brain injury (TBI), using ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), glial fibrillary acidic protein (GFAP), or a combination thereof. Also disclosed herein are methods, and kits for use in said methods, that aid in determining whether a subject that has sustained an orthopedic injury and sustained or may have sustained an injury to the head would benefit from and thus receive an imaging procedure, such as MRI or head computerized tomography (CT) scan based on the levels of GFAP and/or UCH-L1. These methods involve detecting levels and changes in levels of GFAP and/or UCH-L1 in biological samples taken from a subject at time points within 48 hours after the subject has sustained or may have sustained an injury to the head.

公开(公告)号：WO2019113525A2

公开(公告)日：2019-06-13

申请号：PCT/US2018/064587

申请日：2018-12-07

Applicant: ABBOTT LABORATORIES

Inventor： MCQUISTON, Beth ,  DATWYLER, Saul ,  CHANDRAN, Raj

IPC: G01N33/68

Abstract: Disclosed herein are methods, and kits for use in said methods, that aid in the diagnosis and evaluation of a subject that has sustained an orthopedic injury and sustained or may have sustained an injury to the head, such as mild traumatic brain injury (TBI), using ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), glial fibrillary acidic protein (GFAP), or a combination thereof. Also disclosed herein are methods, and kits for use in said methods, that aid in determining whether a subject that has sustained an orthopedic injury and sustained or may have sustained an injury to the head would benefit from and thus receive an imaging procedure, such as MRI or head computerized tomography (CT) scan based on the levels of GFAP and/or UCH-L1. These methods involve detecting levels and changes in levels of GFAP and/or UCH-L1 in biological samples taken from a subject at time points within 48 hours after the subject has sustained or may have sustained an injury to the head.

公开(公告)号：EP3631465A1

公开(公告)日：2020-04-08

申请号：EP18731687.2

申请日：2018-05-25

Applicant: Abbott Laboratories

Inventor： MCQUISTON, Beth ,  ROGERS, Justin ,  MARINO, Jaime ,  CHANDRAN, Raj ,  ZHANG, Tiaming ,  DATWYLER, Saul

IPC: G01N33/68 ,  A61B5/00

公开(公告)号：EP4448179A1

公开(公告)日：2024-10-23

申请号：EP22854335.1

申请日：2022-12-16

Applicant: Abbott Laboratories

Inventor： LEE, Tony ,  KARABATSOS, Peter ,  SCHAPALS, Andrew ,  VIRTANEN, Antti ,  MCQUISTON, Beth ,  JEFFREY, Craig A. ,  MARINO, Jaime ,  CHANDRAN, Raj ,  DATWYLER, Saul ,  TAYLOR, Alison

IPC: B01L3/00 ,  B32B7/00 ,  G01N33/68 ,  G01N33/74 ,  G01N33/76 ,  G01N33/78

公开(公告)号：WO2023034777A1

公开(公告)日：2023-03-09

申请号：PCT/US2022/075638

申请日：2022-08-30

Applicant: ABBOTT LABORATORIES ,  ZHANG, Hongwei ,  ABBOTT POINT OF CARE INC.

Inventor： MCQUISTON, Beth ,  DATWYLER, Saul ,  CHANDRAN, Raj

IPC: G01N33/68

Abstract: Disclosed herein are methods and systems of determining whether a subject's levels of GFAP, UCH-L1, or GFAP and UCH-L1 are elevated in a sample collected from the subject. The methods comprise determining whether the levels of GFAP, UCH-L1, or GFAP and UCH-L1 are elevated in the sample, and communicating the determination on or from an instrument. The methods may be used to aid in the diagnosis and evaluation of a subject (e.g., a human subject) that has sustained or may have sustained an injury to the head, such as to determine whether the subject is suffering from a mild, moderate, severe, or moderate to severe traumatic brain injury (TBI).

公开(公告)号：WO2022245920A1

公开(公告)日：2022-11-24

申请号：PCT/US2022/029798

申请日：2022-05-18

Applicant: ABBOTT LABORATORIES

Inventor： MCQUISTON, Beth ,  DATWYLER, Saul ,  CHANDRAN, Raj ,  ZHANG, Hongwei ,  MARINO, Jaime

IPC: G01N33/68 ,  G01N2800/28 ,  G01N33/6896

Abstract: Disclosed herein are methods, and kits for use in said methods, that aid in the diagnosis and evaluation of a pediatric subject for traumatic brain injury (TBI), using ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), glial fibrillary acidic protein (GFAP), or a combination thereof. Also disclosed herein are methods, and kits for use in said methods, that aid in determining whether a pediatric subject would benefit from and thus receive an imaging procedure, such as MRI or head computerized tomography (CT) scan based on the levels of GFAP, UCH-L1 or GFAP and UCH-L1.

公开(公告)号：WO2019133717A1

公开(公告)日：2019-07-04

申请号：PCT/US2018/067683

申请日：2018-12-27

Applicant: ABBOTT LABORATORIES ,  CEDARS-SINAI MEDICAL CENTER ,  VAN EYK, Jennifer ,  MCQUISTON, Beth ,  DATWYLER, Saul ,  CHANDRAN, Raj ,  VENKATRAMAN, Vidya ,  ZHANG, Shenyan

Inventor： VAN EYK, Jennifer ,  MCQUISTON, Beth ,  DATWYLER, Saul ,  CHANDRAN, Raj ,  VENKATRAMAN, Vidya ,  ZHANG, Shenyan

IPC: G01N33/68

Abstract: The present disclosure relates to methods for diagnosing and evaluating a subject that has sustained or may have sustained an injury to the head, such as a traumatic brain injury (TBI). In particular, the present disclosure identifies various biomarkers, the detection and/or differential expression of which can be used to assess the presence or absence of a TBI in a subject, and can be used as a basis for diagnosing a subject as having a specific type of TBI (e.g., severe TBI or subclasses of mild TBI). The various TBI biomarkers can be detected individually or in combination and can be used as an important diagnostic, prognostic, and/or TBI risk stratification tool as part of assessing a subject's TBI status.

公开(公告)号：WO2018218169A1

公开(公告)日：2018-11-29

申请号：PCT/US2018/034694

申请日：2018-05-25

Applicant: ABBOTT LABORATORIES

Inventor： MCQUISTON, Beth ,  ROGERS, Justin ,  MARINO, Jaime ,  CHANDRAN, Raj ,  ZHANG, Tiaming ,  DATWYLER, Saul

IPC: G01N33/68 ,  A61B5/00

Abstract: Disclosed herein are methods that aid in the determination of whether to perform imaging, such as magnetic resonance imaging (MRI) or computerized tomography (CT) scan, on a human subject that has sustained or may have sustained an injury to the head using an early biomarker, such as ubiquitin carboxy-terminal hydrolase LI (UCH-L1), glial fibrillary acidic protein (GFAP), or a combination thereof. These methods involve detecting levels and changes in levels of UCH-L1 and/or GFAP in samples taken from a human subject at time points within 24 hours after the subject has sustained or may have sustained an injury to the head.

公开(公告)号：WO2014152606A2

公开(公告)日：2014-09-25

申请号：PCT/US2014/027524

申请日：2014-03-14

Applicant: ABBOTT LABORATORIES

Inventor： LUO, Menghua ,  PEREIRA, Suzette ,  EDENS, Neile ,  DAVIS, Gerard ,  GAWEL, Susan ,  CHANDRAN, Raj

IPC: A61K31/19

CPC classification number: A61K31/19 ,  G01N33/6893 ,  G01N2333/47 ,  G01N2333/4704 ,  G01N2333/575 ,  G01N2800/52

Abstract: Insulin resistance biomarkers and related methods of using the biomarkers are provided. The biomarkers may be blood biomarkers and include C-peptide, Insulin-Like Growth Factor- Binding Protein 2 (IGFBP-2), and Leptin. Also provided is a method of reducing the effect of prolonged physical inactivity on insulin resistance in a subject who is experiencing prolonged physical inactivity, or who is expected to experience prolonged physical inactivity in the near future.

Abstract translation: 提供了使用生物标志物的胰岛素抵抗生物标志物和相关方法。 生物标志物可以是血液生物标志物，包括C肽，胰岛素样生长因子结合蛋白2（IGFBP-2）和瘦蛋白。 还提供了一种减少长期身体不活动对经历长时间身体不活动的受试者或预期在不久的将来会经历长时间身体不活动的受试者的胰岛素抵抗的影响的方法。