公开(公告)号：EP0217000A3

公开(公告)日：1987-05-20

申请号：EP86108316

申请日：1986-06-19

Applicant: ABBOTT LABORATORIES

Inventor： Hollar, Robert C. ,  Huang, Tung-Ming

IPC: G01N35/02

CPC classification number: B01L3/508 ,  G01N35/025 ,  G01N35/1002 ,  G01N2035/0436 ,  G01N2035/0448

Abstract: Improvements in apparatus for performing an assay to determine the presence or amount of a substance in a test sample, which apparatus comprises means for dispensing one or more reagents from containment means therefor into a reaction vessel and means for dispensing the sample from a sample container into said vessel for reaction with the reagents during performance of the assay are disclosed. The improvements reside in the apparatus further comprising containment means for the reagents integral and in combination with the sample container and the reaction vessel.

公开(公告)号：EP0217000B1

公开(公告)日：1991-01-23

申请号：EP86108316.0

申请日：1986-06-19

Applicant: ABBOTT LABORATORIES

Inventor： Hollar, Robert C. ,  Huang, Tung-Ming

IPC: G01N35/02

CPC classification number: B01L3/508 ,  G01N35/025 ,  G01N35/1002 ,  G01N2035/0436 ,  G01N2035/0448

公开(公告)号：EP0341438A3

公开(公告)日：1990-11-28

申请号：EP89106444.6

申请日：1989-04-11

Applicant: ABBOTT LABORATORIES

Inventor： Hollar, Robert C. ,  Pepe, Curtis J. ,  Genger, Kevin R.

IPC: G01F23/14 ,  G01N35/06

CPC classification number: G01N35/109 ,  G01F23/14 ,  G01N2035/1018 ,  G01N2035/1025

Abstract: For use in testing a large volume of blood samples, portions of which are to be aspirated and then dispensed into one or more reaction wells, a pneumatic sensing system is characterized by an air pressure/vacuum source which is automatically coupled to a disposable pipette tip when the tip is picked up by a programmed gantry to provide a low pressure air flow through the pipette tip as it approaches the surface of the sample to be aspirated. A back pressure developed in the system as the pipette tip closely approaches and contacts the surface of the sample is detected by a pressure transducer which feeds the detected data to the gantry controller which instantaneously raises the pipette tip for purging and then moves it downwardly into the sample a distance equal to the sensed surface level plus a constant distance appropriate for the amount of the sample to be aspirated. Verification of the integrity of the system during both aspiration and dispensing of the samples is provided by the pressure transducer and the controller with a display screen of the controller providing a visual indicator.

公开(公告)号：EP0341438A2

公开(公告)日：1989-11-15

申请号：EP89106444.6

申请日：1989-04-11

Applicant: ABBOTT LABORATORIES

Inventor： Hollar, Robert C. ,  Pepe, Curtis J. ,  Genger, Kevin R.

IPC: G01F23/14 ,  G01N35/06

CPC classification number: G01N35/109 ,  G01F23/14 ,  G01N2035/1018 ,  G01N2035/1025

Abstract: For use in testing a large volume of blood samples, portions of which are to be aspirated and then dispensed into one or more reaction wells, a pneumatic sensing system is characterized by an air pressure/vacuum source which is automatically coupled to a disposable pipette tip when the tip is picked up by a programmed gantry to provide a low pressure air flow through the pipette tip as it approaches the surface of the sample to be aspirated. A back pressure developed in the system as the pipette tip closely approaches and contacts the surface of the sample is detected by a pressure transducer which feeds the detected data to the gantry controller which instantaneously raises the pipette tip for purging and then moves it downwardly into the sample a distance equal to the sensed surface level plus a constant distance appropriate for the amount of the sample to be aspirated. Verification of the integrity of the system during both aspiration and dispensing of the samples is provided by the pressure transducer and the controller with a display screen of the controller providing a visual indicator.

Abstract translation: 为了用于测试大量的血液样品，其中的一部分被吸入然后分配到一个或多个反应孔中，气动感测系统的特征在于气压/真空源，其自动地联接到一次性吸头 当尖端被编程的台架拾取以提供通过移液管尖端的低压空气流，因为其接近待吸取的样品的表面。 当移液管尖端紧密接近并接触样品表面时，在系统中产生的背压由压力传感器检测，压力传感器将检测到的数据馈送到龙门架控制器，立式升高移液管吸头用于清洗，然后向下移动到 样品的距离等于感测到的表面水平加上适合抽吸样本量的恒定距离。 通过压力传感器和控制器提供抽吸和分配样品期间系统完整性的验证，控制器具有控制器的显示屏幕，其提供视觉指示器。

公开(公告)号：EP0217000A2

公开(公告)日：1987-04-08

申请号：EP86108316.0

申请日：1986-06-19

Applicant: ABBOTT LABORATORIES

Inventor： Hollar, Robert C. ,  Huang, Tung-Ming

IPC: G01N35/02

CPC classification number: B01L3/508 ,  G01N35/025 ,  G01N35/1002 ,  G01N2035/0436 ,  G01N2035/0448

Abstract: Improvements in apparatus for performing an assay to determine the presence or amount of a substance in a test sample, which apparatus comprises means for dispensing one or more reagents from containment means therefor into a reaction vessel and means for dispensing the sample from a sample container into said vessel for reaction with the reagents during performance of the assay are disclosed. The improvements reside in the apparatus further comprising containment means for the reagents integral and in combination with the sample container and the reaction vessel.

Abstract translation: 用于进行测定以确定测试样品中物质的存在或数量的装置的改进，该装置包括用于将一种或多种试剂从其容纳装置分配到反应容器中的装置和用于将样品从样品容器分配的装置 所述容器用于在测定过程中与试剂反应。 改进在于该设备还包括用于试剂的容纳装置，并与样品容器和反应容器组合。