公开(公告)号：EP0353591A3

公开(公告)日：1991-03-20

申请号：EP89113616.0

申请日：1989-07-24

Applicant: ABBOTT LABORATORIES

Inventor： Defreese, James Douglas ,  Huang, Tung-Ming ,  Holen, James T. ,  Gray, Robert Carlton ,  Bailey, Mark Wallace ,  Donohue, Joseph Patrick ,  Putterman, Caryn Glickson

IPC: G01N35/02 ,  G01N21/47 ,  G01N33/53

CPC classification number: G01N33/5302 ,  G01J2001/161 ,  G01J2001/1636 ,  G01N21/253 ,  G01N35/00029 ,  G01N2021/0162 ,  G01N2021/478 ,  G01N2035/00099 ,  G01N2035/00752 ,  G01N2035/1025 ,  G01N2201/0415 ,  G01N2201/069 ,  G01N2201/12761

Abstract: A semi-automated biological sample analyzer and subsystems are provided to simultaneously perform a plurality of enzyme immuno assays for himan IgE class antibodies specific to a panel of preselected allergens in each of a plurality of biological samples. A carou­sel is provided to position and hold a plurality of reaction cartridges. Each reaction cartridge includes a plurality of isolated test sites formed in a two dimensional array in a solid phase binding layer con­tained within a reaction well which is adapted to con­tain a biological sample to be assayed. The carousel and cartridges contain structures which cooperate to precisely position the cartridges in each of three separate dimensions so that each cartridge is posi­tioned uniformly. An optical reader operating on a principle of diffuse reflectance is provided to read the results of the assays from each test site of each cartridge. Also provided is a subsystem which provides predetermined lot-specific assay calibration data which is useful for normalizing the results of various assays with respect to predetermined common standard values.

公开(公告)号：EP0353592B1

公开(公告)日：1996-04-24

申请号：EP89113617.8

申请日：1989-07-24

Applicant: ABBOTT LABORATORIES

Inventor： Holen, James T. ,  Hicaro, Enrique, Jr. ,  Putterman, Caryn Glickson ,  Huang, Tung-Ming ,  Merkh, Carl Walter

IPC: G01N35/02 ,  B01L3/00

CPC classification number: B01L3/508 ,  B01L2200/025 ,  B01L2300/021 ,  B01L2300/044 ,  B01L2300/0809 ,  G01N35/025 ,  G01N2035/00752 ,  G01N2035/1025 ,  G06F19/00

Abstract: A semi-automated biological sample analyzer and subsystems are provided to simultaneously perform a plurality of enzyme immuno assays for himan IgE class antibodies specific to a panel of preselected allergens in each of a plurality of biological samples. A carousel is provided to position and hold a plurality of reaction cartridges. Each reaction cartridge includes a plurality of isolated test sites formed in a two dimensional array in a solid phase binding layer contained within a reaction well which is adapted to contain a biological sample to be assayed. The carousel and cartridges contain structures which cooperate to precisely position the cartridges in each of three separate dimensions so that each cartridge is positioned uniformly. An optical reader operating on a principle of diffuse reflectance is provided to read the results of the assays from each test site of each cartridge. Also provided is a subsystem which provides predetermined lot-specific assay calibration data which is useful for normalizing the results of various assays with respect to predetermined common standard values.

公开(公告)号：EP0353592A2

公开(公告)日：1990-02-07

申请号：EP89113617.8

申请日：1989-07-24

Applicant: ABBOTT LABORATORIES

Inventor： Holen, James T. ,  Hicaro, Enrique, Jr. ,  Putterman, Caryn Glickson ,  Huang, Tung-Ming ,  Merkh, Carl Walter

IPC: G01N35/02 ,  B01L3/00

CPC classification number: B01L3/508 ,  B01L2200/025 ,  B01L2300/021 ,  B01L2300/044 ,  B01L2300/0809 ,  G01N35/025 ,  G01N2035/00752 ,  G01N2035/1025 ,  G06F19/00

Abstract: A semi-automated biological sample analyzer and subsystems are provided to simultaneously perform a plurality of enzyme immuno assays for himan IgE class antibodies specific to a panel of preselected allergens in each of a plurality of biological samples. A carou­sel is provided to position and hold a plurality of reaction cartridges. Each reaction cartridge includes a plurality of isolated test sites formed in a two dimensional array in a solid phase binding layer con­tained within a reaction well which is adapted to con­tain a biological sample to be assayed. The carousel and cartridges contain structures which cooperate to precisely position the cartridges in each of three separate dimensions so that each cartridge is posi­tioned uniformly. An optical reader operating on a principle of diffuse reflectance is provided to read the results of the assays from each test site of each cartridge. Also provided is a subsystem which provides predetermined lot-specific assay calibration data which is useful for normalizing the results of various assays with respect to predetermined common standard values.

Abstract translation: 提供半自动化生物样品分析仪和子系统，以同时对多个生物样品中的每一个中预先选择的过敏原的一组特异性的himan IgE类抗体进行多次酶免疫测定。 提供转盘以定位和保持多个反应盒。 每个反应盒包括在包含在反应井内的固相结合层中的二维阵列中形成的多个分离的测试位点，其适于含有要测定的生物样品。 圆盘传送带和墨盒包含结构，其配合以将墨盒精确地定位在三个分开的尺寸中的每一个中，使得每个墨盒均匀地定位。 提供以漫反射原理工作的光学阅读器，以从每个盒的每个测试位置读取测定结果。 还提供了一种子系统，其提供预定的特异性测定校准数据，其可用于相对于预定的共同标准值标准化各种测定的结果。

公开(公告)号：EP0353592A3

公开(公告)日：1991-05-29

申请号：EP89113617.8

申请日：1989-07-24

Applicant: ABBOTT LABORATORIES

Inventor： Holen, James T. ,  Hicaro, Enrique, Jr. ,  Putterman, Caryn Glickson ,  Huang, Tung-Ming ,  Merkh, Carl Walter

IPC: G01N35/02 ,  B01L3/00

CPC classification number: B01L3/508 ,  B01L2200/025 ,  B01L2300/021 ,  B01L2300/044 ,  B01L2300/0809 ,  G01N35/025 ,  G01N2035/00752 ,  G01N2035/1025 ,  G06F19/00

Abstract: A semi-automated biological sample analyzer and subsystems are provided to simultaneously perform a plurality of enzyme immuno assays for himan IgE class antibodies specific to a panel of preselected allergens in each of a plurality of biological samples. A carou­sel is provided to position and hold a plurality of reaction cartridges. Each reaction cartridge includes a plurality of isolated test sites formed in a two dimensional array in a solid phase binding layer con­tained within a reaction well which is adapted to con­tain a biological sample to be assayed. The carousel and cartridges contain structures which cooperate to precisely position the cartridges in each of three separate dimensions so that each cartridge is posi­tioned uniformly. An optical reader operating on a principle of diffuse reflectance is provided to read the results of the assays from each test site of each cartridge. Also provided is a subsystem which provides predetermined lot-specific assay calibration data which is useful for normalizing the results of various assays with respect to predetermined common standard values.

公开(公告)号：EP0217000A3

公开(公告)日：1987-05-20

申请号：EP86108316

申请日：1986-06-19

Applicant: ABBOTT LABORATORIES

Inventor： Hollar, Robert C. ,  Huang, Tung-Ming

IPC: G01N35/02

CPC classification number: B01L3/508 ,  G01N35/025 ,  G01N35/1002 ,  G01N2035/0436 ,  G01N2035/0448

Abstract: Improvements in apparatus for performing an assay to determine the presence or amount of a substance in a test sample, which apparatus comprises means for dispensing one or more reagents from containment means therefor into a reaction vessel and means for dispensing the sample from a sample container into said vessel for reaction with the reagents during performance of the assay are disclosed. The improvements reside in the apparatus further comprising containment means for the reagents integral and in combination with the sample container and the reaction vessel.

公开(公告)号：EP0353591B1

公开(公告)日：1996-04-17

申请号：EP89113616.0

申请日：1989-07-24

Applicant: ABBOTT LABORATORIES

Inventor： Defreese, James Douglas ,  Huang, Tung-Ming ,  Holen, James T. ,  Gray, Robert Carlton ,  Bailey, Mark Wallace ,  Donohue, Joseph Patrick ,  Putterman, Caryn Glickson

IPC: G01N35/02 ,  G01N21/47 ,  G01N33/53

CPC classification number: G01N33/5302 ,  G01J2001/161 ,  G01J2001/1636 ,  G01N21/253 ,  G01N35/00029 ,  G01N2021/0162 ,  G01N2021/478 ,  G01N2035/00099 ,  G01N2035/00752 ,  G01N2035/1025 ,  G01N2201/0415 ,  G01N2201/069 ,  G01N2201/12761

公开(公告)号：EP0217000B1

公开(公告)日：1991-01-23

申请号：EP86108316.0

申请日：1986-06-19

Applicant: ABBOTT LABORATORIES

Inventor： Hollar, Robert C. ,  Huang, Tung-Ming

IPC: G01N35/02

CPC classification number: B01L3/508 ,  G01N35/025 ,  G01N35/1002 ,  G01N2035/0436 ,  G01N2035/0448

公开(公告)号：EP0353591A2

公开(公告)日：1990-02-07

申请号：EP89113616.0

申请日：1989-07-24

Applicant: ABBOTT LABORATORIES

Inventor： Defreese, James Douglas ,  Huang, Tung-Ming ,  Holen, James T. ,  Gray, Robert Carlton ,  Bailey, Mark Wallace ,  Donohue, Joseph Patrick ,  Putterman, Caryn Glickson

IPC: G01N35/02 ,  G01N21/47 ,  G01N33/53

CPC classification number: G01N33/5302 ,  G01J2001/161 ,  G01J2001/1636 ,  G01N21/253 ,  G01N35/00029 ,  G01N2021/0162 ,  G01N2021/478 ,  G01N2035/00099 ,  G01N2035/00752 ,  G01N2035/1025 ,  G01N2201/0415 ,  G01N2201/069 ,  G01N2201/12761

Abstract: A semi-automated biological sample analyzer and subsystems are provided to simultaneously perform a plurality of enzyme immuno assays for himan IgE class antibodies specific to a panel of preselected allergens in each of a plurality of biological samples. A carou­sel is provided to position and hold a plurality of reaction cartridges. Each reaction cartridge includes a plurality of isolated test sites formed in a two dimensional array in a solid phase binding layer con­tained within a reaction well which is adapted to con­tain a biological sample to be assayed. The carousel and cartridges contain structures which cooperate to precisely position the cartridges in each of three separate dimensions so that each cartridge is posi­tioned uniformly. An optical reader operating on a principle of diffuse reflectance is provided to read the results of the assays from each test site of each cartridge. Also provided is a subsystem which provides predetermined lot-specific assay calibration data which is useful for normalizing the results of various assays with respect to predetermined common standard values.

Abstract translation: 提供半自动化生物样品分析仪和子系统，以同时对多个生物样品中的每一个中预先选择的过敏原的一组特异性的himan IgE类抗体进行多次酶免疫测定。 提供转盘以定位和保持多个反应盒。 每个反应盒包括在包含在反应井内的固相结合层中的二维阵列中形成的多个分离的测试位点，其适于含有要测定的生物样品。 圆盘传送带和墨盒包含结构，其配合以将墨盒精确地定位在三个分开的尺寸中的每一个中，使得每个墨盒均匀地定位。 提供以漫反射原理工作的光学阅读器，以从每个盒的每个测试位置读取测定结果。 还提供了一种子系统，其提供预定的特异性测定校准数据，其可用于相对于预定的共同标准值标准化各种测定的结果。

公开(公告)号：EP0217000A2

公开(公告)日：1987-04-08

申请号：EP86108316.0

申请日：1986-06-19

Applicant: ABBOTT LABORATORIES

Inventor： Hollar, Robert C. ,  Huang, Tung-Ming

IPC: G01N35/02

CPC classification number: B01L3/508 ,  G01N35/025 ,  G01N35/1002 ,  G01N2035/0436 ,  G01N2035/0448

Abstract: Improvements in apparatus for performing an assay to determine the presence or amount of a substance in a test sample, which apparatus comprises means for dispensing one or more reagents from containment means therefor into a reaction vessel and means for dispensing the sample from a sample container into said vessel for reaction with the reagents during performance of the assay are disclosed. The improvements reside in the apparatus further comprising containment means for the reagents integral and in combination with the sample container and the reaction vessel.

Abstract translation: 用于进行测定以确定测试样品中物质的存在或数量的装置的改进，该装置包括用于将一种或多种试剂从其容纳装置分配到反应容器中的装置和用于将样品从样品容器分配的装置 所述容器用于在测定过程中与试剂反应。 改进在于该设备还包括用于试剂的容纳装置，并与样品容器和反应容器组合。