公开(公告)号：WO2006050109A2

公开(公告)日：2006-05-11

申请号：PCT/US2005/038958

申请日：2005-10-28

Applicant: ABBOTT LABORATORIES ,  DAI, Yujia ,  HARTANDI, Kresna ,  MICHAELIDES, Michael, M.

Inventor： DAI, Yujia ,  HARTANDI, Kresna ,  MICHAELIDES, Michael, M.

CPC classification number: C07D471/04 ,  C07D487/04

Abstract: Compounds having the formula (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Abstract translation: 具有式（I）的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备所述化合物的方法，含有所述化合物的组合物以及使用所述化合物的治疗方法。

公开(公告)号：WO2004113304A1

公开(公告)日：2004-12-29

申请号：PCT/US2004/016166

申请日：2004-05-21

Applicant: ABBOTT LABORATORIES ,  DAI, Yujia ,  DAVIDSEN, Steven, K. ,  ERICSSON, Anna, M. ,  HARTANDI, Kresna ,  JI, Zhiqin ,  MICHAELIDES, Michael, R.

Inventor： DAI, Yujia ,  DAVIDSEN, Steven, K. ,  ERICSSON, Anna, M. ,  HARTANDI, Kresna ,  JI, Zhiqin ,  MICHAELIDES, Michael, R.

IPC: C07D231/56

CPC classification number: C07D231/56 ,  C07D261/20 ,  C07D275/04 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D409/04 ,  Y02P20/582

Abstract: Compounds having the formula (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Abstract translation: 具有式（I）的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。

公开(公告)号：WO2003070244A1

公开(公告)日：2003-08-28

申请号：PCT/US2003/005510

申请日：2003-02-21

Applicant: ABBOTT LABORATORIES

Inventor： KYM, Philip, R. ,  HARTANDI, Kresna ,  GAO, Ju ,  PHELAN, Kathleen, M. ,  AKRITOPOULOU-ZANZE, Irini ,  COLLINS, Christine, A. ,  VASUDEVAN, Anil ,  VERZAL, Mary, K.

IPC: A61K31/4706

CPC classification number: C07D401/12 ,  C07D215/46 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

Abstract: The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders. The present invention is directed to the compouds of formula (I).

Abstract translation: 本发明涉及黑色素浓缩激素（MCH）通过黑色素浓缩激素受体的作用的拮抗作用，其可用于预防或治疗进食障碍，体重增加，肥胖，生殖和性行为异常，甲状腺激素 分泌，利尿和水/电解质体内平衡，感觉加工，记忆，睡眠，唤醒，焦虑，抑郁，癫痫发作，神经变性和精神疾病。 本发明涉及式（I）的化合物。

公开(公告)号：WO2002070507A2

公开(公告)日：2002-09-12

申请号：PCT/US2002/004541

申请日：2002-01-16

Applicant: ABBOTT LABORATORIES

Inventor： KYM, Philip, R. ,  LANE, Benjamin, C. ,  PRATT, John, K. ,  VON GELDERN, Tom ,  WINN, Martin ,  PATEL, Jyoti, R. ,  ARENDSEN, David, L. ,  AKRITOPOULOU-ZANZE, Irini ,  ASHWORTH, Kimba, L. ,  HARTANDI, Kresna ,  BRENNEMAN, Jehrod

IPC: C07D311/80

CPC classification number: C07D407/04 ,  C07D311/80 ,  C07D409/04

Abstract: Compounds of formula (I) are useful for treating type (II) diabetes, obesity, hyperglycemia, inadequate glucose clearance, hyperinsulinemia, hypertriglyceridemia, and high-circulating glucocorticoid levels, preparations of the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Abstract translation: 式（I）化合物可用于治疗II型糖尿病，肥胖症，高血糖症，葡萄糖清除不足，高胰岛素血症，高甘油三酯血症和高循环糖皮质激素水平，所述化合物的制剂，含有 化合物和使用这些化合物的治疗方法。

公开(公告)号：EP1807424A2

公开(公告)日：2007-07-18

申请号：EP05815246.3

申请日：2005-10-28

Applicant: ABBOTT LABORATORIES

Inventor： DAI, Yujia ,  HARTANDI, Kresna ,  MICHAELIDES, Michael, M.

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

CPC classification number: C07D471/04 ,  C07D487/04

Abstract: Compounds having the formula (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：EP1638941B1

公开(公告)日：2010-06-02

申请号：EP04776083.0

申请日：2004-05-21

Applicant: ABBOTT LABORATORIES

Inventor： DAI, Yujia ,  DAVIDSEN, Steven, K. ,  ERICSSON, Anna, M. ,  HARTANDI, Kresna ,  JI, Zhiqin ,  MICHAELIDES, Michael, R.

IPC: C07D231/56 ,  C07D403/12 ,  C07D261/20 ,  C07D401/12 ,  C07D403/04 ,  C07D401/04 ,  C07D409/04 ,  C07D275/04 ,  C07D405/12 ,  A61K31/423 ,  A61K31/428 ,  A61P35/00 ,  A61K31/416

CPC classification number: C07D231/56 ,  C07D261/20 ,  C07D275/04 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D409/04 ,  Y02P20/582

公开(公告)号：EP1807424B1

公开(公告)日：2012-04-18

申请号：EP05815246.3

申请日：2005-10-28

Applicant: ABBOTT LABORATORIES

Inventor： DAI, Yujia ,  HARTANDI, Kresna ,  MICHAELIDES, Michael, M.

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

CPC classification number: C07D471/04 ,  C07D487/04

Abstract: Compounds having the formula (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：EP1638941A1

公开(公告)日：2006-03-29

申请号：EP04776083.0

申请日：2004-05-21

Applicant: ABBOTT LABORATORIES

Inventor： DAI, Yujia ,  DAVIDSEN, Steven, K. ,  ERICSSON, Anna, M. ,  HARTANDI, Kresna ,  JI, Zhiqin ,  MICHAELIDES, Michael, R.

IPC: C07D231/56 ,  C07D403/12 ,  C07D261/20 ,  C07D401/12 ,  C07D403/04 ,  C07D401/04 ,  C07D409/04 ,  C07D275/04 ,  C07D405/12 ,  A61K31/423 ,  A61K31/428 ,  A61P35/00 ,  A61K31/416

CPC classification number: C07D231/56 ,  C07D261/20 ,  C07D275/04 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D409/04 ,  Y02P20/582

Abstract: Compounds having the formula (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.