公开(公告)号：WO2010111572A1

公开(公告)日：2010-09-30

申请号：PCT/US2010/028790

申请日：2010-03-26

Applicant: ABBOTT LABORATORIES ,  CARROLL, William A ,  DART, Michael J. ,  FROST, Jennifer M. ,  LATSHAW, Steven P. ,  LI, Tongmei ,  LIU, Bo ,  PEDDI, Sridhar ,  WANG, Xueqing ,  KOLASA, Teodozyi ,  NELSON, Derek W. ,  PEREZ-MEDRANO, Arturo

Inventor： CARROLL, William A ,  DART, Michael J. ,  FROST, Jennifer M. ,  LATSHAW, Steven P. ,  LI, Tongmei ,  LIU, Bo ,  PEDDI, Sridhar ,  WANG, Xueqing ,  KOLASA, Teodozyi ,  NELSON, Derek W. ,  PEREZ-MEDRANO, Arturo

IPC: C07D405/06 ,  C07D413/06 ,  C07D417/06 ,  A61K31/433 ,  A61P25/04

CPC classification number: C07D417/06 ,  C07D405/06 ,  C07D413/06

Abstract: Disclosed herein are compounds of formula (I) wherein Ring A and R 1 are as defined in the specification. Pharmaceutical compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and pharmaceutical compositions are also disclosed.

Abstract translation: 本文公开了式（I）的化合物，其中环A和R 1如说明书中所定义。 还公开了包含这些化合物的药物组合物，以及使用这些化合物和药物组合物治疗病症和障碍的方法。

公开(公告)号：WO2008028094A1

公开(公告)日：2008-03-06

申请号：PCT/US2007/077321

申请日：2007-08-31

Applicant: ABBOTT LABORATORIES ,  NELSON, Derek W. ,  LATSHAW, Steven P.

Inventor： NELSON, Derek W. ,  LATSHAW, Steven P.

IPC: C07D495/04 ,  A61K31/381 ,  A61P25/00

CPC classification number: C07D495/04

Abstract: The present invention relates to thiophene containing compounds of formula (I), wherein R1, R2, R3, and n are as defined in the specifcation, pharmaceutical compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and pharmaceutical compositions.

Abstract translation: 本发明涉及含噻吩的式（I）化合物，其中R 1，R 2，R 3和n如在规定中所定义，包含这些化合物的药物组合物，以及使用这些化合物和药物组合物治疗病症和障碍的方法。

公开(公告)号：WO2010033543A2

公开(公告)日：2010-03-25

申请号：PCT/US2009/057088

申请日：2009-09-16

Applicant: ABBOTT LABORATORIES ,  CARROLL, William A ,  DART, Michael J. ,  FROST, Jennifer M. ,  LATSHAW, Steven P. ,  KOLASA, Teodozyi ,  LI, Tongmei ,  PEDDI, Sridhar ,  LIU, Bo ,  PEREZ-MEDRANO, Arturo ,  PATEL, Meena ,  WANG, Xueqing ,  NELSON, Derek W.

Inventor： CARROLL, William A ,  DART, Michael J. ,  FROST, Jennifer M. ,  LATSHAW, Steven P. ,  KOLASA, Teodozyi ,  LI, Tongmei ,  PEDDI, Sridhar ,  LIU, Bo ,  PEREZ-MEDRANO, Arturo ,  PATEL, Meena ,  WANG, Xueqing ,  NELSON, Derek W.

IPC: C07D231/40 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14

CPC classification number: C07D405/12 ,  C07D231/40 ,  C07D285/135 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: Disclosed herein are cannabinoid receptor ligands of formula (I), wherein A 1 , A 5 , R x , X 4 , and z are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

Abstract translation: 本文公开了式（I）的大麻素受体配体，其中A1，A5，Rx，X4和z如说明书中所定义。 还公开了包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。

公开(公告)号：WO2008079683A2

公开(公告)日：2008-07-03

申请号：PCT/US2007/087163

申请日：2007-12-12

Applicant: ABBOTT LABORATORIES ,  GOMTSYAN, Arthur R. ,  SCHMIDT, Robert G. ,  DAANEN, Jerome F. ,  BAYBURT, Erol K. ,  LEE, Chih-Hung ,  LATSHAW, Steven P.

Inventor： GOMTSYAN, Arthur R. ,  SCHMIDT, Robert G. ,  DAANEN, Jerome F. ,  BAYBURT, Erol K. ,  LEE, Chih-Hung ,  LATSHAW, Steven P.

IPC: C07C275/32 ,  C07D311/58 ,  C07D215/42 ,  A61K31/17 ,  A61K31/353 ,  A61K31/47 ,  A61P25/04

CPC classification number: C07C275/32 ,  C07D215/12 ,  C07D215/42 ,  C07D215/54 ,  C07D311/58 ,  C07D311/74

Abstract: The present application is directed to compounds that are TRPV1 antagonictc and have formula(I): wherein variables Ar 1 , L 1 , R 1 , R 2 , R 3 , R 4 , R 5 , Y 1 , Y 2 , and Y 3 , are as defined in the description, which are useful for treating disorders caused by or exacerbated by vanilloid receptor activity.

Abstract translation: 本申请涉及TRPV1拮抗剂并具有式（I）的化合物：其中变量Ar 1，L 1，R 1， R 2，R 3，R 4，R 5，Y 1， Y 2和Y 3是如描述中所定义的，其可用于治疗由香草素受体活性引起或加剧的病症。

公开(公告)号：EP2334646A2

公开(公告)日：2011-06-22

申请号：EP09792591.1

申请日：2009-09-16

Applicant: Abbott Laboratories

Inventor： CARROLL, William A ,  DART, Michael J. ,  FROST, Jennifer M. ,  LATSHAW, Steven P. ,  KOLASA, Teodozyj ,  LI, Tongmei ,  PEDDI, Sridhar ,  LIU, Bo ,  PEREZ-MEDRANO, Arturo ,  PATEL, Meena ,  WANG, Xueqing ,  NELSON, Derek W.

IPC: C07D231/40 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14

CPC classification number: C07D405/12 ,  C07D231/40 ,  C07D285/135 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: Disclosed herein are cannabinoid receptor ligands of formula (I), wherein A
1 , A
5 , R
x , X
4 , and z are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

公开(公告)号：EP2134678A2

公开(公告)日：2009-12-23

申请号：EP07855088.6

申请日：2007-12-12

Applicant: ABBOTT LABORATORIES

Inventor： GOMTSYAN, Arthur R. ,  SCHMIDT, Robert G. ,  DAANEN, Jerome F. ,  BAYBURT, Erol K. ,  LEE, Chih-Hung ,  LATSHAW, Steven P.

IPC: C07C275/32 ,  C07D311/58 ,  C07D215/42 ,  A61K31/17 ,  A61K31/353 ,  A61K31/47 ,  A61P25/04

CPC classification number: C07C275/32 ,  C07D215/12 ,  C07D215/42 ,  C07D215/54 ,  C07D311/58 ,  C07D311/74

Abstract: The present application is directed to compounds that are TRPV1 antagonists and have formula: (I); wherein variables Ar1, L1, R1, R2, R3, R4, R5, Y1, Y2, and Y3, are as defined in the description, which are useful for treating disorders caused by or exacerbated by vanilloid receptor activity.

公开(公告)号：EP2411382A1

公开(公告)日：2012-02-01

申请号：EP10724166.3

申请日：2010-03-26

Applicant: Abbott Laboratories

Inventor： CARROLL, William A ,  DART, Michael J. ,  FROST, Jennifer M. ,  LATSHAW, Steven P. ,  LI, Tongmei ,  LIU, Bo ,  PEDDI, Sridhar ,  WANG, Xueqing ,  KOLASA, Teodozyj ,  NELSON, Derek W. ,  PEREZ-MEDRANO, Arturo

IPC: C07D405/06 ,  C07D413/06 ,  C07D417/06 ,  A61K31/433 ,  A61P25/04

CPC classification number: C07D417/06 ,  C07D405/06 ,  C07D413/06

Abstract: Disclosed herein are compounds of formula (I) wherein Ring A and R
1 are as defined in the specification. Pharmaceutical compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and pharmaceutical compositions are also disclosed.